Percutaneous absorption agent containing Ailamode, preparation method and medical uses thereof

A technology of transdermal absorbent and transdermal accelerator, which is applied in the field of transdermal absorbents containing iguratimod, which can solve problems such as difficulty in taking medicine, no report of topical transdermal absorption of iguratimod, and damage to the body
CN101401783AInactive Publication Date: 2009-04-08杨喜鸿
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
杨喜鸿
Publication Date
2009-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a transdermal absorbent containing Iguratimod, which comprises gellies, ointment, and cream, wherein the mass percentage content of the Iguratimod in the transdermal absorbent is between 0.1 and 10 percent, and preferably the mass percentage content of the Iguratimod in the transdermal absorbent is between 0.4 and 3 percent; and the invention also discloses requirements of the transdermal absorbent on the selections of matrix and a transdermal enhancer. Furthermore, the invention also provides a method for preparing the transdermal absorbent containing the Iguratimod and pharmaceutical application thereof.
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Description

technical field

[0001] The invention belongs to the technical field of pharmacy, and relates to a transdermal absorbent containing iguratimod, a preparation method thereof and its application in medicine. Background technique

[0002] Iguratimod (Iguratimod, T-614, CAS RN: 123663-49-0), the chemical name is N-[3-(formamide)-4-oxo-6-phenoxy-4H-1-benzo Pyran-7-yl]-methanesulfonamide, English name: N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-methanesulfonamide, the molecular structure is as follows:

[0003] Molecular formula C 17 h 14 N 2 o 6 S, molecular weight 374.4.

[0004] Iguratimod is a new non-steroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2. It has antipyretic and analgesic effects, anti-arthritis effects, and immune regulation effects. Sexual arthritis, osteoarthritis and ankylosing spondylitis have excellent curative effect, and can also relieve pain and joint pain caused by muscle and soft tissue damage. It can not on...

Claims

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