Beta-elemi alkene bulk medicament and method of preparing its preparations

A technology of elemene and raw materials, applied in the field of preparation of β-elemene raw materials and its preparations, can solve the problems of high cost, complicated production equipment, and limited sources

Inactive Publication Date: 2009-04-08
沈阳万爱普利德医药科技有限公司
View PDF3 Cites 25 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a kind of β-elemene containing β-elemene in order to overcome the existing problems in the prior art, such as the limitation of sources of high-content β-elemene raw mater...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Beta-elemi alkene bulk medicament and method of preparing its preparations
  • Beta-elemi alkene bulk medicament and method of preparing its preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A, get the natural herbal medicine curcuma tuber as raw material;

[0024] B, the medicinal material Zedoary is steam-distilled to obtain Zedoary volatile oil, wherein the content of β-elemene is 6.0%;

[0025] c. Put the raw material obtained in b into a molecular distillation device for distillation. The vacuum degree is 20Pa, the temperature of the tower is 60°C, the material flow rate is 3mL / min, the temperature of the condensation surface is 15°C, and the speed of the scraping film is 350rpm. The water temperature is 60°C, molecular distillation removes monoterpenes and sesquiterpenoids with low boiling points; °C, the rotating speed of the scraping film is 300 rpm, the temperature of the circulating water is 60 °C, molecular distillation is carried out, and the distillate is collected to obtain β-elemene with a content of 45.6%.

[0026] d. The 45.6% β-elemene sample obtained in step c was extracted three times with 70% ethanol aqueous solution having a five-fold...

Embodiment 2

[0030] a, taking the fresh leaves of natural plant Javanese citronella as raw material;

[0031] b. The medicinal material Javanese citronella is steam-distilled to obtain Javanese volatile oil, wherein the content of β-elemene is 5.0%;

[0032]c. Put the raw material obtained in b into a molecular distillation device for distillation. The vacuum degree is 30Pa, the temperature of the tower is 70°C, the material flow rate is 3mL / min, the temperature of the condensation surface is 15°C, and the speed of the scraping film is 400rpm. The water temperature is 65°C, molecular distillation removes monoterpenes and sesquiterpenoids with low boiling points; °C, the rotating speed of the scraping film was 350 rpm, and the temperature of the circulating water was 65 °C to carry out molecular distillation, and the distillate was collected to obtain β-elemene with a content of 48.6%.

[0033] d. The 48.6% β-elemene sample obtained in step c was extracted three times with quintuple volume...

Embodiment 3

[0037] a, taking the fresh leaves of natural plant Solidago as raw material;

[0038] b. Obtaining Solidago volatile oil by supercritical extraction from the leaves of Solidago, wherein the content of β-elemene is 16.0%;

[0039] c. Put the raw material obtained in b into a molecular distillation device for distillation. The vacuum degree is 30Pa, the temperature of the tower is 70°C, the material flow rate is 3mL / min, the temperature of the condensation surface is 15°C, and the speed of the scraping film is 450rpm. The water temperature is 65°C, molecular distillation removes monoterpenes and sesquiterpenoids with low boiling points; °C, the rotating speed of the scraping film is 400 rpm, and the temperature of the circulating water is 65 °C, molecular distillation is carried out, and the distillate is collected to obtain β-elemene with a content of 70.0%.

[0040] d. The 70.0% β-elemene sample obtained in step c was extracted three times with quintuple volume concentration ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Granularityaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention provides a method for preparing high-purity beta elemene from natural plants containing the beta elemene such as curcuma zedoary (earthnuts or tubers of the curcuma zedoary), cedronella (fresh leaves of the cedronella), yellowtop (roots, stems, leaves, flowers and seeds of the yellowtop) and so on, which can improve the production efficiency from starting materials to the high-purity beta elemene and reduce production cost. Compared with the prior art, the method is mainly different in that the roots, stems, leaves, flowers and seeds of the natural plants are taken as raw materials; oleum volatile of specific parts of the natural plants is obtained by methods for extracting different oleum volatiles, and is distilled by molecular distillation method to remove compositions with high boiling points and non-volatile compositions; impurity compositions are removed by the ethanol extraction method and silver nitrate complex extraction method; and finally the beta elemene with the content between 95.0 and 99.9 percent is obtained through reduced pressure distillation or rectification. The bulk pharmaceutical chemicals not only can be prepared into oral dosing preparation such as emulsion oral liquid, self-emulsifying/ self-microemulsifying capsules, soft capsules and so on, but also can be prepared into non-alimentary dosing preparation such as emulsion injection, liquid drugs injection, transdermal absorbent, lung sprays, suppository and so on. The method has the advantages of novel design, concise operating steps, mild operating conditions and improvement of the production efficiency of the beta elemene.

Description

Technical field: [0001] The invention relates to a preparation method of a β-elemene raw material drug and its preparation. Background technique: [0002] Elemene is isolated from zedoary oil and citronella oil, and has been widely used to treat cancer. The earliest anticancer drug was zedoary oil injection made from zedoary oil, which can only be used locally The treatment of cervical cancer by tumor drug administration has a long course of treatment and inconvenient administration operation, while other various cancers cannot be effectively treated with this injection. In order to solve the problem of the limitation of the use of zedoary oil injection, people have separated elemene with fixed proportioning components from zedoary oil and citronella oil to make elemene injection. In addition to local tumor administration and regional administration, the milk injection can also be injected intravenously, and can treat cervical cancer, brain tumor, digestive tract malignant ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C13/19C07C7/00C07C7/04C07C7/12C07C7/10A61K31/01A61P35/00
Inventor 孙敏鸽李淑斌周莉刘丹王宏
Owner 沈阳万爱普利德医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap