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Total alkaloids extraction of corydalis, its preparation method, medicine composition containing the total alkaloids extraction and application thereof

A technology of total alkaloids and extracts is applied in the field of total alkaloids without total alkaloids, the preparation thereof, the pharmaceutical composition containing total alkaloids without total alkaloids in summer, and the application field of pharmaceutical preparations, which can solve the problem of frequent injection of injections and large doses of medicines. , inconvenient storage and other problems, to achieve the effect of controllability of internal quality, efficient preparation method, safe and effective pharmacological efficacy

Inactive Publication Date: 2007-10-17
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are still big deficiencies in the clinical application of Xia Tian Wu preparations. For example, Xia Tian Wu tablets have the disadvantages of large dosage and inconvenient storage; injections require frequent injections, which brings great inconvenience to patients.

Method used

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  • Total alkaloids extraction of corydalis, its preparation method, medicine composition containing the total alkaloids extraction and application thereof
  • Total alkaloids extraction of corydalis, its preparation method, medicine composition containing the total alkaloids extraction and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: A kind of preparation method that does not have total alkaloid in summer

[0043] Take 1 kg of summer crude drug coarse powder, add 3 liters of 1% (v / v) hydrochloric acid solution to soak overnight, put it in a 50 liter percolation cylinder, percolate with the above-mentioned solution of 1% (v / v), collect the percolation solution until the alkaloid reaction was negative. A total of about 12 liters of percolate was collected. Per 100ml of percolation liquid is equivalent to about 8.33g of crude drug.

[0044] Take the percolation liquid, put the macroporous adsorption resin D-101 with a column bed volume of 2000 milliliters; wash with 1% (v / v) hydrochloric acid solution of 1 to 2 times the column volume; then use 10% (w / w) Sodium hydroxide aqueous solution was eluted to light color; then washed with deionized water to near neutral; then statically eluted and collected with 75% ethanol until the eluate had no alkaloid reaction; the eluate was then passed t...

Embodiment 2

[0045] Embodiment 2: A kind of preparation method that does not have total alkaloid in summer

[0046] Get 1 kilogram of crude drug crude powder in summer, add 3 liters of 10% (v / v) phosphoric acid solution to soak overnight, put it in a 50 liter percolation cylinder, percolate with the above-mentioned solution of 10% (v / v), collect the percolation solution until the alkaloid reaction was negative. A total of about 15 liters of percolate was collected. Per 100ml of percolation liquid is equivalent to about 6.67g of crude drug.

[0047] Get the percolation liquid, and put it on the macroporous adsorption resin ME-2 with a column bed volume of 2000 milliliters; wash with 10% (v / v) phosphoric acid solution of 1 to 2 times column volume; then use 15% (w / w) Sodium hydroxide aqueous solution was eluted to light color; then washed with deionized water to near neutral; then statically eluted and collected with 95% ethanol until the eluate had no alkaloid reaction; the eluate was the...

Embodiment 3

[0048] Embodiment 3: A kind of preparation method that does not have total alkaloid in summer

[0049] Take 1 kg of summer crude drug coarse powder, add 3 liters of 0.01% (v / v) sulfuric acid solution to soak overnight, put it into a 50 liter percolation cylinder, percolate with the above-mentioned solution of 0.01% (v / v), collect the percolation solution until the alkaloid reaction was negative. A total of about 10 liters of percolate was collected. Every 100 milliliters of percolate is equivalent to about 10 grams of crude drug.

[0050] Take the percolation liquid, and put the macroporous adsorption resin D-101 with a column bed volume of 2000 milliliters; wash with 0.01% (v / v) sulfuric acid solution of 1 to 2 times the column volume; then use 0.05% (w / w) Elute with sodium hydroxide aqueous solution until the color is light; then wash with deionized water until nearly neutral; then use 60-95% ethanol to dynamically elute and collect until there is no alkaloid reaction in t...

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Abstract

The present invention discloses a Rhizoma Corydalis Decumbentis total alkaloids extract, its preparation method, pharmaceutical composition containing same. The total alkaloids mainly comprise : macleyine, tetrahydropalmatine, bicucalline, palmatine hydrochloride, 'xiawuning' alkaloid, corydaline harmine, other alkaloid and extract. The preparation method is : using Rhizoma Corydalis Decumbentis as material, adding right amount of polar solvent for leaching, merging the leachate, carrying out large pore adsorption resin chromatography, eluting impurity with diluted acid and alkaline aqueous solution orderly, eluting using polar organic solvent, collecting elution liquor, eliminating impurity further by alumina column adsorption, Collecting after-column liquid, concentrating liquor to obtain the Rhizoma Corydalis Decumbentis total alkaloids extract. The present invention also discloses a pharmaceutical composition containing the total alkaloids extract and uses of the pharmaceutical composition in preparing tablet, capsule, soft capsule, suppository, granula, transdermal absorption agent, drop pills, oral disintegrating agent, slow release agent, freeze-drying powder injection etc.

Description

technical field [0001] The invention relates to the field of traditional Chinese herbal medicines, in particular to the total summer free alkaloids, a preparation method thereof, a pharmaceutical composition containing the total summer free alkaloids, and the application of the pharmaceutical composition in pharmaceutical preparations. Background technique [0002] Summer Wu is the dry tuber or whole herb of Corydalis decumbens (Thunb.) Pers., a plant of the genus Corydalis in the family Papaveraceae. Summer Wu is widely distributed in Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hunan and other provinces. Commonly used Chinese herbal medicine in my country has the effects of promoting blood circulation, dredging collaterals, promoting qi, and relieving pain. It is mainly used for the treatment of stroke and hemiplegia caused by high blood pressure and cerebrovascular disease, and has a good effect on rheumatoid arthritis, sciatica, and sequelae of polio. Its main acti...

Claims

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Application Information

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IPC IPC(8): C07D471/04C07D491/12C07D491/153C07G5/00A61K31/395A61K31/44A61K36/66A61K9/20A61K9/48A61K9/02A61K9/14A61K9/19C07D221/00
Inventor 蒋爱芳杨义芳
Owner SHANGHAI INST OF PHARMA IND
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