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Flexible nanoliposomes with charges for cosmetics and preparation method thereof

A nano-liposome, charged technology, applied in cosmetic preparations, cosmetics, cosmetic preparations and other directions, can solve the problems of not easy to promote transdermal absorption, low self-stability, etc., and achieve good skin permeability, The effect of high encapsulation efficiency, drug loading, and good stability

Active Publication Date: 2012-04-04
江妍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ordinary liposomes can improve the stability and safety of use, their own stability is still relatively low; and it is not easy to promote transdermal absorption

Method used

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  • Flexible nanoliposomes with charges for cosmetics and preparation method thereof
  • Flexible nanoliposomes with charges for cosmetics and preparation method thereof
  • Flexible nanoliposomes with charges for cosmetics and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Dissolve 100mg of soybean lecithin, 16mg of stearylamide, and 15mg of cholesterol in chloroform by ultrasonication in a water bath, dissolve 25mg of asiaticoside, 0.26mg of vitamin E and BHA mixed antioxidants in a small amount of ethanol, and mix with chloroform; Sodium cholate and 1.7 mg hyaluronic acid were dissolved in phosphate buffer at pH 7.0; the aforementioned phosphate buffer and chloroform solution were sonicated in a water bath to form a uniform emulsion, and after standing for 30 minutes, rotary evaporation obtained lipid body suspension; the liposome suspension was ultrasonicated for 30 cycles with a probe-type ultrasonic cell disruptor (5 seconds per cycle, 5 seconds at rest), homogenized 3 times with an AVESTIN high-pressure homogenizer, and passed through The AVESTIN extruder passes through a 100nm microporous membrane 10 times, and the liposome suspension extruded is put into a dialysis bag (molecular cut-off 8000-14000) for dialysis for 6 hours; the li...

Embodiment 2

[0040] 120mg of hydrogenated soybean lecithin, 20mg of stearylamide, 18mg of cholesterol were ultrasonically dissolved in chloroform, and 0.25mg of vitamin E and BHA mixed antioxidants were dissolved in a small amount of ethanol, and then mixed with chloroform; 2000UI epidermal active factor ( EGF), 15 mg sodium cholate, and 1.7 mg hyaluronic acid were dissolved in phosphate buffer at pH 7.0; the aforementioned phosphate buffer and chloroform solution were ultrasonically formed into a uniform emulsion in a water bath, and after standing for 30 minutes, rotate Evaporate to get liposome suspension; After liposome suspension is ultrasonically 30 cycles (every cycle ultrasonic 5 seconds, intermittent 5 seconds) with probe type ultrasonic cell disruptor, use AVESTIN high-pressure homogenizer homogeneous 3 time, and then through the microporous membrane of 100nm by AVESTIN extruder 10 times, the liposome suspension extruded was put into dialysis bag (molecular cut-off 8000-14000) and...

Embodiment 3

[0043] Dissolve 10mg of dipalmitoylphosphatidylcholine, 2mg of stearamide, and 2mg of cholesterol in chloroform by ultrasonication in a water bath, dissolve 0.20mg of vitamin C and BHA mixed antioxidants in a small amount of ethanol, and mix with chloroform; Grass root, 1.6 mg sodium cholate, and 1.7 mg hyaluronic acid were dissolved in phosphate buffer solution with pH 7.0; the aforementioned phosphate buffer solution and chloroform solution were ultrasonically formed into a uniform emulsion in a water bath, and after standing for 30 minutes, The liposome suspension was obtained by rotary evaporation; the liposome suspension was ultrasonicated for 30 cycles with a probe-type ultrasonic cell disruptor (5 seconds per cycle, 5 seconds at rest), and then homogenized with an AVESTIN high-pressure homogenizer 3 times, then through the microporous filter membrane of 100nm by AVESTIN extruder 10 times, the liposome suspension of extruding is put into dialysis bag (molecular cut-off 80...

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Abstract

The invention relates to flexible nanoliposomes with charges for cosmetics and a preparation method thereof. The flexible nanoliposomes with the charges for the cosmetics comprise the following components in part by weight: 1-1000 parts of neutral phospholipid, 0.5-500 parts of phospholipid with the charges, 1-1000 parts of cholesterol, 0.5-500 parts of surface active agent, 0.1-20 parts of hyaluronic acid, 0.5-250 parts of cosmetic active ingredients and 100-8000 parts of freeze drying protective agent. The flexible nanoliposomes with the charges for the cosmetics can obviously improve the stabilities of the cosmetic active ingredients, promote the percutaneous absorption and the interaction efficiency of the active ingredients, and also improve the retention and action time of the active ingredients on the skin surface and the skin deep layer; and the flexible nanoliposomes with the charges for the powdery cosmetic active ingredients are also benefit to the use, transportation and storage. The preparation method of the flexible nanoliposomes with the charges can adopt a mechanized method, so the stability of the product technology and quality is good, and the repeatability is high.

Description

technical field [0001] The invention relates to a charged flexible nano-liposome, more specifically, the invention relates to a charged flexible nano-liposome for cosmetics and a preparation method thereof. Background technique [0002] With the development of technology, instruments and methodologies, people's understanding of the human body itself has become more and more profound, and the understanding of skin physiology and pathology has penetrated to the level of genes and molecular biology. With a huge impetus, more and more biologically active animal and plant ingredients and / or biopolymer ingredients are applied to the cosmetics industry, which has achieved huge social and economic benefits. [0003] However, applying these biologically active substances to cosmetics faces many difficulties, mainly in the following two aspects: [0004] 1. How to solve the stability of these biologically active substances. The stability of such substances is not only determined by t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/73A61Q19/00
Inventor 江妍
Owner 江妍
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