Resveratrol flexible liposome and preparation method thereof

A flexible liposome, resveratrol technology, applied in the directions of liposome delivery, pharmaceutical formulations, cosmetic preparations, etc. and other problems to achieve the effect of improving transdermal absorption

Inactive Publication Date: 2010-11-03
SHANGHAI JAHWA UNITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, resveratrol is slightly soluble in water, has poor biocompatibility, is not easy to penetrate the skin, and is not suitable for making hydrophilic cosmetics
In addition, resveratrol is also very easy to photolyze
The above-mentioned properties of resveratrol limit its application in the field of cosmetics

Method used

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  • Resveratrol flexible liposome and preparation method thereof
  • Resveratrol flexible liposome and preparation method thereof
  • Resveratrol flexible liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 1.2g of resveratrol, 3g of soybean lecithin, and 0.01g of vitamin E, put them in an eggplant-shaped bottle, mix them, and heat and dissolve them with 30ml of chloroform at 45°C to obtain a lipid solution; rotate and volatilize the organic solvent at 55°C to form Lipid film; add 94.5 g of distilled water dissolved with 0.2 g of sodium cholate, 1.8 g of propylene glycol, and 0.015 g of propyl p-hydroxybenzoate at 60 ° C to hydrate to form a lipid hydration suspension; hydrate the The suspension is homogeneously emulsified under high pressure to obtain flexible liposomes of resveratrol.

Embodiment 2

[0049] Take 0.3g of resveratrol, 0.8g of soybean lecithin, 0.01g of butylated hydroxyanisole, and 1.0g of glycerol monooleate, put them in an eggplant-shaped bottle, mix them, heat and melt at 100°C, and obtain a lipid solution; The lipid solution was dispersed in 97.4 g of distilled water in which 0.4 g of polysorbate 80, 0.015 g of sodium metabisulfite, and 0.01 g of ethyl p-hydroxybenzoate were dissolved at 80 ° C to form a lipid hydration suspension; the hydration suspension High-pressure homogeneous emulsification to obtain flexible liposomes of resveratrol.

Embodiment 3

[0051] Take 1.2g resveratrol, 3g soybean lecithin, 12g propylene glycol, 10g caprylic acid glycerides, 3g dicetyl phosphate, 0.02g butylated hydroxytoluene, mix, heat and melt at 95°C to obtain a lipid solution; The lipid solution was dispersed in 58.8 g of 80°C distilled water containing 12 g of polysorbate 80, 0.008 g of ethylenediaminetetraacetic acid, and 0.005 g of benzalkonium chloride to form a lipid hydration suspension; the hydration suspension High-pressure homogeneous emulsification to obtain flexible liposomes of resveratrol.

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Abstract

The invention discloses a resveratrol flexible liposome which is characterized by comprising the following components in mass percent (in terms of the weight of the liposome): 0.1-10% of resveratrol, 0.5-10% of phospholipid and 0.1-30% of flexible agent. In addition, the invention also discloses a preparation method of the resveratrol flexible liposome. The resveratrol flexible liposome of the invention has high flexibility and penetrability and can greatly improve the percutaneous absorption of active components.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to resveratrol flexible liposomes and a preparation method thereof. Background technique [0002] Resveratrol (Resveratrol), also known as stilbenol, chemical name is 3,4,5-trihydroxystilbene (3,4,5-trihydrolystilbence), mainly found in grapes, knotweed, peanuts, alfalfa, mulberry In plants such as fenugreek, mama vine, and pagoda japonica, there are non-flavonoid polyphenolic compounds containing stilbene structures, which have two structures, cis and trans, and mainly exist in trans in nature. [0003] Studies have proved that resveratrol has excellent anti-aging effects and is listed as "one of the 100 most effective anti-aging substances". Its mechanism of action is that it can remove free radicals in the body, activate functional factors in the body, promote and maintain The smooth metabolism makes the internal and external secretions coordinated. The free radical scaveng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/34A61K8/55A61Q19/00
CPCA61K8/39A61K8/14A61Q19/00A61K9/0014A61K8/63A61K8/553A61K9/127A61K31/05A61K8/34A61K8/347A61K8/86A61P17/10A61P17/18
Inventor 史青金日昇陈建明陈明李慧良吕洛高保安
Owner SHANGHAI JAHWA UNITED
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