Resveratrol flexible liposome and preparation method thereof
A flexible liposome, resveratrol technology, applied in the directions of liposome delivery, pharmaceutical formulations, cosmetic preparations, etc. and other problems to achieve the effect of improving transdermal absorption
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Embodiment 1
[0047] Take 1.2g of resveratrol, 3g of soybean lecithin, and 0.01g of vitamin E, put them in an eggplant-shaped bottle, mix them, and heat and dissolve them with 30ml of chloroform at 45°C to obtain a lipid solution; rotate and volatilize the organic solvent at 55°C to form Lipid film; add 94.5 g of distilled water dissolved with 0.2 g of sodium cholate, 1.8 g of propylene glycol, and 0.015 g of propyl p-hydroxybenzoate at 60 ° C to hydrate to form a lipid hydration suspension; hydrate the The suspension is homogeneously emulsified under high pressure to obtain flexible liposomes of resveratrol.
Embodiment 2
[0049] Take 0.3g of resveratrol, 0.8g of soybean lecithin, 0.01g of butylated hydroxyanisole, and 1.0g of glycerol monooleate, put them in an eggplant-shaped bottle, mix them, heat and melt at 100°C, and obtain a lipid solution; The lipid solution was dispersed in 97.4 g of distilled water in which 0.4 g of polysorbate 80, 0.015 g of sodium metabisulfite, and 0.01 g of ethyl p-hydroxybenzoate were dissolved at 80 ° C to form a lipid hydration suspension; the hydration suspension High-pressure homogeneous emulsification to obtain flexible liposomes of resveratrol.
Embodiment 3
[0051] Take 1.2g resveratrol, 3g soybean lecithin, 12g propylene glycol, 10g caprylic acid glycerides, 3g dicetyl phosphate, 0.02g butylated hydroxytoluene, mix, heat and melt at 95°C to obtain a lipid solution; The lipid solution was dispersed in 58.8 g of 80°C distilled water containing 12 g of polysorbate 80, 0.008 g of ethylenediaminetetraacetic acid, and 0.005 g of benzalkonium chloride to form a lipid hydration suspension; the hydration suspension High-pressure homogeneous emulsification to obtain flexible liposomes of resveratrol.
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