Sodium heparin loaded hydrogel slow-release plaster

Abstract

The invention relates to a medical dressing, in particular to sodium heparin loaded hydrogel slow-release plaster which comprises a fixed layer, a backing layer and a hydrogel functional layer, wherein the backing layer and the hydrogel functional layer are sequentially arranged on the fixed layer, and the hydrogel functional layer is prepared from hydrophilic high-molecular compounds, sodium heparin and transdermal penetration enhancer water solution through high-energy ray radiation or freezing and thawing cycle or combination of high-energy ray radiation and freezing and thawing cycle. The hydrogel slow-release plaster has the advantages that sheet solid hydrogel materials synthesized by the hydrophilic high-molecular compounds with high biological safety have high biological safety, water content and the like, a molecular structure is compact, water desorption rate can be controlled, service time is prolonged, in addition, the hydrogel slow-release plaster prepared from the sheet solid hydrogel materials serving as a medicine slow-release component is simple to operate and convenient to use and can be timely removed if discomfort and adverse reaction occur, and deterioration of adverse reaction is avoided.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a hydrogel sustained-release patch loaded with heparin sodium. Background technique [0002] Heparin sodium is the sodium salt of aminodextran sulfate extracted from the lungs and intestinal mucosa of pigs or cattle. It belongs to mucopolysaccharides and is an anticoagulant. The common dosage forms are injections and creams. Injection is a common dosage form of heparin sodium, but after injection, the local blood concentration of the drug is high, which may easily lead to abnormal bleeding reactions in the whole body or adverse reactions such as subcutaneous congestion and induration at the injection site; and cream is easy to change after application Dry, short action time, unable to achieve long-term drug penetration, poor therapeutic effect. In summary, the current common dosage forms of heparin sodium all have defects that affect the therapeutic effect during use. [0003] Hydrogel is ...

AI Technical Summary

Problems solved by technology

[0004] At present, there are patents that load heparin sodium in an amorphous hydrogel with carbomer and alginate as the main components, and apply it to the treatment site so that the loaded heparin sodium can play a therapeutic role through transdermal administration. , but due to the loose molecular structure of the amorphous hydrogel, the water loss rate is fast, and there is also the disadvantage that the active ingredient cannot be released after dehydration and drying

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