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Anticancer analgesic percutaneous absorption preparation

A technology of transdermal absorption preparation and transdermal penetration enhancer, which is applied in the field of anti-cancer and pain-relieving pharmaceutical preparations, can solve the problems of mylabris being highly toxic, and achieve the effects of overcoming adverse effects, avoiding the first-pass effect, and causing little harm

Inactive Publication Date: 2008-07-30
崔建平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned drugs have some restrictions when taken internally, for example: mylabris is very poisonous, it should be used with caution when taken internally, and it is contraindicated for pregnant women

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A transdermal absorption preparation for anti-cancer and pain-relieving is characterized in that it is made according to the following method: (1) taking the following components as raw materials: 0.24 kg of mylabris and 0.3 kg of nuxychia; (2) adding equivalent raw materials 6 times the weight, extraction with 75% ethanol aqueous solution, heating and extraction for 2 hours, filtering the extract, recovering the filtrate and concentrating and drying at 80°C to obtain the extract; (3) adding a transdermal penetration enhancer Borneol is made, and the addition amount of Borneol is 5% of extract quality; Make various transdermal dosage forms according to conventional methods, as disclosed by the plaster under appendix I I of " Pharmacopoeia of the People's Republic of China " in 2005 edition The method is made into rubber ointment, cataplasm and patch etc. in the plaster; or the gel is made according to the disclosed method of the gel under the C item; or is prepared accor...

Embodiment 2

[0018] A transdermal absorption preparation for anti-cancer and pain-relieving is characterized in that it is made according to the following method: (1) taking the following components as raw materials: 0.03 kg of Mylabris, 2.4 kg of Nuxe chinensis; (2) adding equivalent raw materials 7 times the weight, 50% ethanol aqueous solution for volume percentage concentration, extracting by heating for 3 hours, extracting 3 times, filtering the extract, recovering the filtrate and concentrating and drying at 80°C to obtain the extract; (3) adding permeate The skin penetration enhancer clove oil is made, and the addition amount of clove oil is 5% of extract quality, makes various dosage forms by the method for embodiment 1.

Embodiment 3

[0020] A transdermal absorption preparation for anti-cancer and pain relief, which is characterized in that it is made according to the following method: (1) taking the following components as raw materials: 0.01 kg of mylabris and 0.1 kg of nuxychonzi; (2) adding equivalent raw materials 5 times the weight, the volume percent concentration is 95% ethanol aqueous solution extraction, the extraction time is 1.5 hours, the extract is filtered, the filtrate is recovered and concentrated and dried at 80°C to obtain the extract; (3) add the transdermal penetration enhancer Peppermint oil, the addition of peppermint oil is 2% of the quality of the extract, and various formulations are made according to the method of Example 1.

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Abstract

The invention discloses an anticancer and analgesic percutaneous absorption preparation, which is prepared by the following method: (1) adopting the materials according to the following weight proportion: cantharis of 0.01 to 0.3 portion; nux vomica of 0.1 to 3 portions; (2) extracting the materials by ethanol solution and obtaining the extractant; (3) adding transdermal penetration enhancers. As adopting transdermal target medication system and being added with the auxiliary materials accepted by pharmacy, the anticancer and analgesic percutaneous absorption preparation of the invention can be made into adhesive plaster in emplastrum, cataplasma paste, and emplastrum; or the invention can be made into plaster, gelata, ointment, liniment, aerosol or spray agent, so the invention can deliver the medicine successively with long time, maintain necessary blood concentration, overcome the bad influence on human body when the plasma concentration reaches peak value after oral administration, and avoid the first-pass effect. The invention has little damage on liver and kidney and reaches the purpose of taking effect both from the symptom and the cause root.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical preparation for anticancer and pain relief. Background technique [0002] As we all know, malignant tumor is a common disease that seriously threatens human life and health, and it is a difficult problem recognized all over the world. Patients with advanced cancer often suffer from unbearable pain, which reduces the quality of life of patients to an extremely low level. Most of the drugs used for analgesia are narcotic analgesics. These drugs can relieve pain well, but because of this These drugs have a high incidence of tolerance and addiction, which restricts their application. [0003] As a treasure of our country, traditional Chinese medicine plays a huge role in the treatment of diseases. Among them: Mylabris (MYLABRIS) is the dry body of Mylabris phalerata Pallas or Mylabris cichoriiLinnaeus, an insect of the family Coralaceae. Its function cures mainly: d...

Claims

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Application Information

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IPC IPC(8): A61K36/56A61K36/714A61K47/10A61K47/12A61K47/44A61P35/00A61P25/04A61K35/64
Inventor 杨吉田崔建平
Owner 崔建平
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