Transdermal spray preparation for plastic mist membranization and preparation method of transdermal spray preparation

Abstract

The invention discloses a transdermal spray preparation for plastic mist membranization and a preparation method of the transdermal spray preparation. The transdermal spray preparation for plastic mist membranization comprises the following components in percentage by mass: 2%-20% of medicine, 2%-20% of mesoporous nano silica aerogel, 2%-30% of a dispersing agent, 1%-15% of atomizing agent, 1%-15% of a film-forming agent and 35-90% of a volatile solvent. The mesoporous nano silica aerogel is a controlled-release mesoporous nanometer carrier; the porosity of the mesoporous nano silica aerogel is 90%-99.8%; the aperture of the mesoporous nano silica aerogel is 20-100nm; the three-dimensional nano particle size is 2-70nm; the specific surface area is 100-1,000m<2> / g; the density is 0.003-30g / cm<3>; and the heat-conducting coefficient is 0.01-0.018w / m.k. According to the transdermal spray preparation, long-time continuous transdermal penetration of the medicine can be effectively achieved; the constant blood concentration is maintained; and the preparation has the characteristics of high transdermal absorption rate, high transdermal absorption amount and is stable and efficient.

Description

technical field [0001] The invention relates to a plastic atomized transdermal spray preparation with mesoporous nano silicon dioxide as a carrier and a preparation method thereof. Background technique [0002] At present, the commonly used drug-containing preparations that act on the human body in vitro are mainly patches, gels, and creams, which have many defects, such as skin irritation caused by the closing effect of the patch on the skin; Drug quality problems caused by crystallization; and large-area patch products that affect the appearance after administration. The main problem of semi-solid dosage forms such as gels and ointments is that they cannot be dosed accurately and are easily removed by friction, which not only affects the transdermal effect, but also contaminates clothing and reduces patient compliance. [0003] Ketoprofen and ibuprofen are commonly used non-steroidal anti-inflammatory drugs (NSAIDs). Ketoprofen has a chiral center and is generally availa...

AI Technical Summary

Problems solved by technology

Ketoprofen has a chiral center and is generally available in the form of racemate for clinical use. However, only the D-isomer has anti-inflammatory, anti-rheumatic and analgesic effects, and the L-isomer has almost no pharmacological activity.

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