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Gastrodia elata genin transdermal gel for central nervous system disease treatment

A technology of gastrodiaglycin and central nervous system, which is applied in the field of pharmaceutical preparations and can solve the problems of long course of disease and short duration of action.

Inactive Publication Date: 2010-07-28
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gastrodin and its active metabolite gastrodin are eliminated quickly in the body, and the action time is short, while central nervous system diseases often have a long course, and frequent medication brings a lot of inconvenience to patients

Method used

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  • Gastrodia elata genin transdermal gel for central nervous system disease treatment
  • Gastrodia elata genin transdermal gel for central nervous system disease treatment
  • Gastrodia elata genin transdermal gel for central nervous system disease treatment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] prescription:

[0075] Gastrodin 5g Carbomer 1g

[0076] Propylene glycol 5g Triethanolamine 1.5g

[0077] Azone 1g Ethylparaben 0.03g

[0078] Ethanol 30g Water 56.47g

[0079] Preparation method: Dissolve carbomer in 50ml of water, mix gastrodin, propylene glycol, azone, ethylparaben and ethanol and add it, add triethanolamine dropwise under stirring, add water to 100g, stir well, A clear gel was obtained.

Embodiment 2

[0081] prescription:

[0082] Gastrodin 1g Carbomer 1g

[0083] Glycerol 10g Triethanolamine 1.5g

[0084] Turpentine 1g Sodium Benzoate 0.5g

[0085] Propylene Glycol 20g Water 65g

[0086] Preparation method: Dissolve carbomer in 50ml of water, mix gastrodin, glycerin, turpentine, sodium benzoate and propylene glycol, add triethanolamine dropwise under stirring, add water to 100g, and stir well to obtain Clear gel.

Embodiment 3

[0088] prescription:

[0089] Gastrodin 0.1g Sodium Carboxymethylcellulose 3g

[0090] Glycerol 10g Borneol 0.5g

[0091] Chlorobutanol 0.1g Ethanol 5g

[0092] Water 81.3g

[0093] Preparation method: Dissolve carboxymethyl cellulose sodium in 50ml of water, mix gastrodin, glycerin, borneol, chlorobutanol and ethanol, add water to 100g, stir well to obtain clarity shaped gel.

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Abstract

The invention provides a gastrodia elata genin transdermal gel for central nervous system disease treatment, which includes the components of (by weight percentage): 0.1-10% of gastrodia elata genin, 0.5-2% of transdermal sorbefacient, 0.03-1% of preservative, 5-10% of moisturizers, 1-4% of gel substrate, 5-35%alcohol solvent and water in the rest percentage. The gastrodia elata genin of transdermal gel is the main active component of gastrodia elata, has good transdermal penetration property, and can be absorbed through skin to enter blood circulation for having sedative and hypnotic medical efficacies; so the gastrodia elata genin transdermal gel is used for the treatment of central nervous system diseases such as insomnia, dizzy and neurasthenia, and has the advantages of durable efficacy, safety and easy production and preparation.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical preparation with p-hydroxybenzyl alcohol (4-Hydroxybenzyl alcohol) as an active ingredient. Background technique [0002] Competition in modern society is increasingly fierce, the pace of life is accelerated, and mental pressure is increased. Central nervous diseases such as insomnia, dizziness, and neurasthenia often plague people's work and life. However, there are currently no specific drugs and methods for treating such diseases. Mainly use symptomatic treatment. Among them, injection and oral preparations with gastrodin as the active ingredient are commonly used drugs. [0003] Gastrodin is an active ingredient isolated from the precious traditional Chinese medicine Gastrodia elata, which can be hydrolyzed to generate gastrodin aglycone. The chemical name of Gastrodia aglycone is 4-Hydroxybenzyl alcohol, and its chemical structure is shown in the figure ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/05A61K47/38A61K47/36A61K47/32A61K47/10A61P25/00
Inventor 刘中秋蔡铮黄娟吴越
Owner SOUTHERN MEDICAL UNIVERSITY
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