Transdermal medicament delivery system containing donepezil compound, preparation and preparation method

Abstract

The invention discloses a transdermal medicament delivery system containing a donepezil compound, a transdermal preparation and a preparation method. The transdermal medicament delivery system comprises the following components in percentage by weight: 0.1 to 50 percent of donepezil or acid radical salt thereof, 1 to 95 percent of skeleton polymer, 0.1 to 60 percent of transdermal penetration enhancer, 0 to 10 percent of cross linker, 0.5 to 60 percent of humectant, 0.02 to 10 percent of bacteriostatic agent, 0.02 to 30 percent of pH regulator and 0 to 90 percent of solvent. The system is used for treating light, medium and severe senile dementia, can maintain long-time stable medicament delivery of at least 3 days, has better performance, is convenient for medicament delivery, and can reduce the administration frequency and increase the compliance of patients; and meanwhile, the transdermal path avoids first-pass effect on gastrointestinal tracts and liver due to oral administration of medicaments, and the system has higher bioavailability and obvious advantages in medicinal application.

Description

technical field [0001] The invention relates to a transdermal drug delivery system containing a donepezil compound, a preparation method and application. Background technique [0002] Alzheimer's disease, also known as Alzheimer's disease (AD), is a primary degenerative encephalopathy that occurs in old age and early old age, and its characteristic pathological changes are cerebral cortex atrophy, accompanied by β-Amyloid deposition, neurofibrillary tangles, loss of number of large memory neurons, and formation of senile plaques. The daily life ability of AD patients is reduced, which brings endless pain and troubles to themselves and the people around them. The average survival period of AD patients is 5.5 years. After cardiovascular disease, cerebrovascular disease and cancer, AD has become the "fourth killer" of the health of the elderly. In the near future, our country will enter an aging society, accompanied by a problem that cannot be ignored - the incidence of AD is...

AI Technical Summary

Problems solved by technology

However, the above patents all need to be taken daily and for a long time, which cannot solve the shortcomings of poor compliance and high clinical drop-out rate of AD patients

Chinese patent CN101167697A discloses a long-acting sustained and controlled release composition of donepezil compound and its preparation method, but all of them are injection or oral preparations, which also have the above-mentioned defects

Images