Transdermal patch containing paeoniflorin and glycyrrhetinic acid and method for preparing same

A technology of glycyrrhetinic acid and transdermal patch, applied in the field of medicine, can solve the problem of not giving glycyrrhizic acid

Active Publication Date: 2011-10-19
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN101433529A discloses a glycyrrhizic acid transdermal preparation and its preparation process, but does not give any data that can explain the transdermal penetration and absorption of glycyrrhizic acid, it is only used to treat skin diseases

Method used

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  • Transdermal patch containing paeoniflorin and glycyrrhetinic acid and method for preparing same
  • Transdermal patch containing paeoniflorin and glycyrrhetinic acid and method for preparing same
  • Transdermal patch containing paeoniflorin and glycyrrhetinic acid and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Paeoniflorin 6, glycyrrhetinic acid 30, diethanolamine 10, azone 2, butanol 5

[0043] Hydroxyl group-containing acrylate pressure sensitive adhesive ( 87-2287)47

Embodiment 2

[0045] Paeoniflorin 30, Glycyrrhetinic Acid 6, Triethylamine 3, Lauryl Alcohol 10, Butanol 5, Silicone Rubber Pressure Sensitive Adhesive 46

Embodiment 3

[0047] Paeoniflorin 18, Glycyrrhetinic acid 18, Triethanolamine 6, Isopropyl myristate 10, Butanol 8, Natural rubber pressure-sensitive adhesive 40

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PUM

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Abstract

The invention discloses composition of a paeoniflorin- glycyrrhetinic acid transdermal patch and a method for preparing the same. The transdermal patch consists of a lining, a drug-carrying pressure sensitive adhesive layer and an anti-sticking layer, wherein the drug-carrying pressure sensitive adhesive layer comprises the following ingredients in part by weight: 1 to 20 parts of paeoniflorin and 1 to 20 parts of glycyrrhetinic acid or 5 to 30 parts of extract of paeoniflorin and 5 to 30 parts of extract of glycyrrhetinic acid, organic alkali, a penetration enhancer and butyl alcohol. The content of the paeoniflorin of the extract of paeoniflorin and the content of the glycyrrhetinic acid of the extract of glycyrrhetinic acid are 20 to 90 percent respectively. The main active ingredients of common peony and liquorice can enter skin and subcutaneous tissues by transdermal penetration to effectively alleviate and inhibit spasm and pain in local tissues.

Description

technical field [0001] The invention relates to the technical field of medicine, and provides a transdermal drug delivery system capable of suppressing local spasm and pain, specifically a transdermal patch containing paeoniflorin and glycyrrhetinic acid and a preparation method. Background technique [0002] Shaoyao Gancao Decoction comes from the book "Treatise on Febrile Diseases", which is formulated by Zhongjing for the acute syndrome of typhoid fever, sweating and death of yang, and leg spasms after yang recovery. In recent years, according to modern pharmacological research, Shaoyao Gancao Decoction has been widely used in internal medicine, surgery, gynecology and various pain syndromes. It is used in syndrome differentiation and has satisfactory curative effect. [0003] Shaoyao Gancao Decoction is traditionally administered orally. Its curative effect is definite. It has pharmacological effects on uterine smooth muscle and gastrointestinal tract. Large doses can l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/56A61K9/70A61P29/00A61P15/00
Inventor 汪晴
Owner DALIAN UNIV OF TECH
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