Application of ionic type cyclodextrin derivative in preparation of medicine preparation for iontophoresis transdermal administration

A pharmaceutical preparation and iontophoresis technology, which is applied in drug delivery, non-active ingredients of polymer compounds, pharmaceutical formulations, etc., can solve the problems of limited transdermal penetration of drugs, and achieve increased transdermal penetration rate, enhanced electric field response, The effect of increasing solubility
CN101897977AInactive Publication Date: 2010-12-01ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2010-12-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses the application of ionic type cyclodextrin derivative in preparation of medicine preparation for iontophoresis transdermal administration. The ionic type cyclodextrin derivative comprises one or two of cationic cyclodextrin derivative and anionic cyclodextrin derivative; the medicine is selected from one or more of molecular type medicine, charged medicine with the dissolubility less than 1mg / ml, faintly acid charged medicine with the dissociation constant p Ka larger than 4, or alkalescent charged medicine with the dissociation constant p Ka less than 4. The ionic type cyclodextrin derivative applied to the iontophoresis transdermal administration improves the transdermal penetration rate of the molecular type medicinem and the charged medicine with low dissolubility or degree of dissociation.
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Description

technical field

[0001] The invention relates to the application field of cyclodextrin derivatives, in particular to the application of an ionic cyclodextrin derivative in the preparation of pharmaceutical preparations for iontophoresis transdermal administration. Background technique

[0002] After more than 30 years of rapid development since the 1970s, modern transdermal drug delivery technology has researched and developed more than 30 transdermal patches (TTS) through the combination of many technologies including physics, chemistry and biology. product. The rapid development of transdermal drug delivery technology is due to the unique advantages of transdermal drug delivery, such as transdermal drug delivery can avoid the first-pass effect of the liver and degradation of drugs in the gastrointestinal tract; drugs can be released at the required rate, maintain Constant effective blood drug concentration, avoiding the peak and valley phenomenon of blood drug concentratio...

Claims

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