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Transdermal liquid preparation

A liquid preparation and absorption type technology, applied in the field of external preparation composition, can solve the problem of shortening transdermal absorption, and achieve the effect of reducing skin irritation and shortening lag time

Active Publication Date: 2018-01-19
MEDRX CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] On the one hand, in order to improve the transdermal absorbability, some documents propose to add transdermal absorption enhancers such as higher fatty acid, higher alcohol, fatty acid ester (for example, patent documents 2 and 3), but, about containing propylene glycol and phosphatidylcholine Colloidal liquid formulations of bases, techniques to shorten the lag time of transdermal absorption and improve skin permeability have not been proposed

Method used

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Examples

Experimental program
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Embodiment

[0042] [Lizatriptan-containing liquid preparations]

[0043] Liquid formulations with the ingredients (wt %) shown in Table 1 were prepared. The obtained liquid preparation was subjected to an in vivo blood drug concentration evaluation test using rats. The results of the blood drug concentration (ng / ml) of rizatriptan at each blood sampling point are listed in Table 1 together. also, figure 1 It is a schematic diagram of the transition of blood drug concentration.

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Abstract

The present invention addresses the problem of providing a liquid preparation for external application, which has a shortened transdermal absorption lag time and has excellent transdermal absorption properties. The present invention also addresses the problem of providing a liquid preparation for external application, which is less irritative to skin. The problems can be solved by a transdermal liquid preparation comprising: (a) propylene glycol in an amount of 40 to 98% by weight; (b) phosphatidylcholine in an amount of 0.1 to 5% by weight; (c) oleyl alcohol and / or isostearyl alcohol in an amount of 0.1 to 10% by weight; and (d) a medicine in an amount of 0.1 to 25% by weight. It is preferred that the transdermal liquid preparation additionally contains an alkanol amine. The alkanol amineis preferably triethanolamine.

Description

technical field [0001] The present invention relates to a percutaneous absorption type liquid preparation. Specifically, the present invention relates to an external preparation composition containing medicine and phosphatidylcholine. Background technique [0002] As a technique for transdermally absorbing various drugs, there is known a percutaneous absorption type liquid preparation in which drugs and phosphatidylcholine are dissolved in a propylene glycol solvent to form a colloidal dispersion (Patent Document 1). This technology has shown a high effect in the skin penetration of various drugs with a simple composition. However, depending on the type of drug, it is sometimes required to achieve extremely high absorbability in a short period of time, and it is necessary to further increase skin permeability. [0003] On the one hand, in order to improve the transdermal absorbability, some documents propose to add transdermal absorption enhancers such as higher fatty acid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/13A61K31/445A61K47/10A61K47/18A61K47/24A61P43/00
CPCA61K47/10A61K47/18A61K47/24A61K9/10A61K31/13A61K31/445A61K31/135A61K31/4196A61P25/04A61P25/06A61P25/28A61P43/00A61K9/0014
Inventor 山崎启子
Owner MEDRX CO LTD
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