Preparation method and application of galvanic-response transdermal drug delivery system

A transdermal drug delivery system and a technology for transdermal drug delivery are applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients to improve the transdermal penetration rate, physical and chemical stability. The effect of good, easy-to-satisfy preparation conditions

Active Publication Date: 2016-02-24
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] About the electroresponse transdermal drug delivery system of the present invention, there is no report

Method used

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  • Preparation method and application of galvanic-response transdermal drug delivery system
  • Preparation method and application of galvanic-response transdermal drug delivery system
  • Preparation method and application of galvanic-response transdermal drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Preparation and Characterization of Carboxylated Carbon Nanotubes

[0044] Commercially purchased MWCNTs (500 mg) were dispersed in 500 mL 98% H 2 SO 4 and 65% HNO 3 Add the mixed acid (3:1, v / v) into a ball mill tank, protect it with liquid nitrogen, and ball mill for 20 minutes at a speed of 590 rpm. Wash with ultrapure water (18.2MΩ) to neutrality, collect after suction filtration (0.45μm vinylidene chloride microporous filter membrane), and vacuum dry at 60°C for 24h to obtain carboxylated carbon nanotubes (MWCNTs-COOH).

[0045] In a 250 mL single-neck round bottom flask equipped with a magnetic stirring rotor, add the above-mentioned oxidized MWCNTs-COOH (40 mg) and dilute nitric acid (2.6 mol L -1 , 120mL), after ultrasonic treatment for 30min, put it into an oil bath and install a spherical condenser and tail gas absorption tube, heat and reflux and stir for 24h. After the reaction, cool, wash with ultrapure water until neutral and collect, and va...

Embodiment 2

[0049] Example 2: Preparation of Aceclofenac (Aceclofenac, abbreviated as AC) electroreactive transdermal drug delivery system

[0050] Accurately weigh AC to make 25mg·mL -1 (95% ethanol) solution 30mL, set aside. Weigh 500mg of MWCNTs-COOH and place it in a ball mill jar, add the liquid medicine in 3 times, 10mL each time; 590rpm·min under the protection of liquid nitrogen -1 Ball mill for 6 minutes. The suspension was taken out and passed through a 0.45 μm microporous membrane, the filter cake was washed and filtered with deionized water, and then freeze-dried to obtain the carboxylated multi-walled carbon nanotube-loaded aceclofenac complex (AC-MWCNTs-COOH) .

[0051] Infrared characterization of AC-MWCNTs-COOH, see description Figure 4 As shown (A, B, and C in the figure are the infrared spectra of the aceclofenac raw material drug, the load AC-MWCNTs-COOH, and the carboxylated carbon nanotube MWCNTs-COOH respectively), the carboxyl peak of the aceclofenac raw materi...

Embodiment 3

[0053] Embodiment 3: Determination of the transdermal rate of aceclofenac electroreactive transdermal drug delivery system

[0054] In order to compare the transdermal rate of aceclofenac electroreactive transdermal drug delivery system (AC-MWCNTs-COOH gel ointment) and common aceclofenac gel ointment (AC gel ointment), the AC gel ointment was first prepared, The difference between the preparation method and process lies in that AC is the raw material drug, and is not loaded with carboxylated carbon nanotubes; no carbon nanotubes are added to the gel matrix.

[0055] Specific operation steps: put 1g 10 was sprinkled in 15 mL of deionized water, and stirred at a low speed for 30 min; weighed 0.5 g of AC, added 5 mL of 95% ethanol to dissolve, and added to the carbomer solution under stirring to obtain a phase A solution. In phase B, weigh 5.5g of NP-700, add 20mL of glycerin, 4mL of propylene glycol, and 4mL of azone, and grind well. Dissolve 2 g of sorbitol and 0.01 g of ED...

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Abstract

The invention relates to a preparation method and application of galvanic-response gel for drugs loaded on carbon nanotubes functionalized with carboxylic groups. The technical scheme includes that the preparation method includes (1) dissolving the drugs by proper solvents and preparing a load by adding the dissolved drugs into the carbon nanotubes functionalized with carboxylic groups prior to refrigeration and ball milling; (2) using the carbon nanotubes, polyacrylic acid, polyvinyl alcohol and the like for forming a gel matrix and adding the load so as to obtain the gel; (3) using the gel for transdermal drug delivery under the action of an external electric field. The preparation method is simple in preparation process, mild in experiment conditions and easy to operate; the poorly water-soluble drugs are loaded on the carbon nanotubes functionalized with carboxylic groups, so that water solubility of the drugs is enhanced; release of the drugs is related to the external electric field, drug transdermal permeation rate can be increased effectively, and accordingly high practical value is achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of an electroreaction transdermal drug delivery system and its application as a drug delivery carrier in topical skin external drug delivery. Background technique [0002] Carbon nanotubes (CNTs) are extremely important inorganic nanoparticles, including single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), whose hollow tubes can accommodate biospecific molecules and drugs. , and carry it into cells or tissues. Drug active molecules are loaded on carbon nanotubes in three ways: one is that carbon nanotubes act as loose absorbents to adsorb drugs in carbon tubes or between carbon bundles; the other is to form complexes with drugs through functionalized carbon nanotube outer walls; Drugs are encapsulated in the cavity of carbon nanotubes. [0003] Carbon nanotubes are insoluble in organic solvents and water, and functio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K9/06A61K31/4375A61K31/4745A61K31/4525A61K31/485A61K31/585A61P35/00
Inventor 邓亚利江志霞蔡鑫剑
Owner SOUTH CHINA AGRI UNIV
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