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Plant extract-mediated drug transdermal introducing system and transdermal method thereof

A plant extract and transdermal technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc.

Inactive Publication Date: 2012-11-28
百源科创分子医学研究所(南通)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the successful delivery of macromolecular drugs such as nucleic acids to the dermis of the skin using plant extracts as transdermal agents

Method used

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  • Plant extract-mediated drug transdermal introducing system and transdermal method thereof
  • Plant extract-mediated drug transdermal introducing system and transdermal method thereof
  • Plant extract-mediated drug transdermal introducing system and transdermal method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] Animal skin penetration enhancement experiment

[0128] 1. Main instruments, reagents and materials

[0129] 1.1 ICR mice: Experimental Animal Center of Nantong University, 4-6 weeks old, weighing 18-20 g, male and female randomly.

[0130] 1.2 Fluorescence-labeled siRNA: Cy3-labeled siRNA (Cy3-siRNA) (Biomicro Biotechnology Co., Ltd.).

[0131] 1.3 Instruments: cryostat (Leica CM1900, Leica, USA); upright fluorescence microscope (X3, Olympus, Japan), etc.

[0132] 1.4 Reagent: 10% (m / V) chloral hydrate (Sinopharm Chemical Reagent Co., Ltd.); medical glue (Guangzhou Baiyun Medical Glue Co., Ltd.); sodium chloride injection (0.9%) (Shandong Kangning Pharmaceutical Co., Ltd.) ; 0.1MPBS (BIOMEC Biotechnology Co., Ltd.); Angelica Essential Oil (Jiangxi Cedar Natural Medicinal Oil Co., Ltd.); Azone (Aladdin Reagent (China) Co., Ltd.).

[0133]1.5 Materials: 1mL disposable syringe, 5mL disposable syringe (Jiangyan Xinsu Medical Instrument Co., Ltd.), disposable cotton swab...

Embodiment 2

[0149] Animal skin transdermal experiment

[0150] 1. Main instruments, reagents and materials

[0151] 1.1 ICR mice: Experimental Animal Center of Nantong University, 4-6 weeks old, weighing 18-20 g, male and female randomly.

[0152] 1.2 Fluorescence-labeled siRNA: Cy3-labeled siRNA (Cy3-siRNA) (Biomicro Biotechnology Co., Ltd.).

[0153] 1.3 Instruments: cryostat (Leica CM1900, Leica, USA); upright fluorescence microscope (X3, Olympus, Japan), etc.

[0154] 1.4 Reagent: 10% (m / V) chloral hydrate (Sinopharm Chemical Reagent Co., Ltd.); medical glue (Guangzhou Baiyun Medical Glue Co., Ltd.); sodium chloride injection (0.9%) (Shandong Kangning Pharmaceutical Co., Ltd.) ; 0.1MPBS (BIOMEC Biotechnology Co., Ltd.); Angelica Essential Oil (Jiangxi Cedar Natural Medicinal Oil Co., Ltd.); Azone (Aladdin Reagent (China) Co., Ltd.).

[0155] 1.5 Materials: 1mL disposable syringe, 5mL disposable syringe (Jiangyan Xinsu Medical Instrument Co., Ltd.), disposable cotton swab, 5mL centr...

Embodiment 3

[0168] Concentration Dependence Experiment of Nucleic Acid Molecule Transdermal Transdermal Drug

[0169] 1. Main instruments, reagents and materials

[0170] 1.1 ICR mice: Experimental Animal Center of Nantong University, 4-6 weeks old, weighing 18-20 g, male and female randomly.

[0171] 1.2 Fluorescence-labeled siRNA: Cy3-labeled siRNA (Cy3-siRNA) (Biomicro Biotechnology Co., Ltd.).

[0172] 1.3 Instruments: cryostat (Leica CM1900, Leica, USA); upright fluorescence microscope (X3, Olympus, Japan), etc.

[0173] 1.4 Reagent: 10% (m / V) chloral hydrate (Sinopharm Chemical Reagent Co., Ltd.); Sodium chloride injection (0.9%) (Shandong Kangning Pharmaceutical Co., Ltd.); Co., Ltd.); Angelica Essential Oil (Jiangxi Cedar Natural Medicinal Oil Co., Ltd.); Jojoba Oil (Zibo Linsen Biological Products Co., Ltd.), etc.

[0174] 1.5 Materials: 1mL disposable syringe, 5mL disposable syringe (Jiangyan Xinsu Medical Instrument Co., Ltd.), disposable cotton swab, 5mL centrifuge tube, op...

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PUM

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Abstract

The present invention discloses a plant extract-mediated drug transdermal introducing system and a transdermal method thereof. The plant extract-mediated drug transdermal introducing system comprises a transdermal introducing agent prepared from at least one plant extract, and biological macromolecules or a preparation thereof. The transdermal method includes: using the transdermal introducing agent to promote penetration, then performing transdermal penetration for the biological macromolecules or the preparation thereof; or mixing the biological macromolecules or the preparation thereof with the transdermal introducing agent to prepare a composite formula preparation for transdermal penetration. The present invention also provides the application of the plant extract-mediated drug transdermal introducing system or the transdermal method thereof in the preparation of skin health products. Preparing skin health products by the system, the biological macromolecules can penetrate into the skin to achieve a better therapeutic effect.

Description

technical field [0001] The invention relates to a drug transdermal delivery system mediated by plant extracts and a transdermal method thereof. Background technique [0002] Abnormal local skin pigmentation caused by excessive and uneven secretion of melanin will form spots or plaques on the face and back of the hands, such as: pregnancy spots, acne marks, birthmarks, moles, freckles, sun spots and age spots. [0003] For centuries, people have used a variety of topical creams to lighten the skin and reduce hyperpigmentation. In recent years, people have used hydroquinone (HQ), magnesium L-ascorbic acid-2-phosphate (MAP), hydroquinone monomethyl ether, N-acetyl-4-S-cysteinephenol and arbutin and other chemical substances to remove pigmentation, but these substances will cause side effects such as local depigmentation, dermatitis, and even canceration and brown and yellow disease, forcing people to look for alternatives (Parvez S et al., Phytother Res.2006, 20 (11): 921-34)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61Q19/02
CPCA61K8/00A61K47/44A61K48/00A61M37/00A61K47/10A61K9/0014A61K47/46A61K8/342A61K8/39A61K8/606A61K8/9789A61K8/9794A61P17/00A61Q19/02
Inventor 陆毅祥张平静朱远源陈建新彭微李铁军冯文建
Owner 百源科创分子医学研究所(南通)有限公司
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