The invention discloses a method for achieving industrial robot off-line programming based on three-dimensional modeling software. The principle of the method is that a three-dimensional modeling software application programming interface (API) which is suitable for COM or object linking and embedding (OLE) and the like is used in the three-dimensional modeling software environment, model and space matrix data in the three-dimensional modeling software are obtained, a robot virtual body model and a mathematical model are built, and a virtual robot motion control system is realized; discretization from a curve to a point is conducted through obtained space line data, and therefore a motion trail of a robot is generated, actual robot operation is simulated; and an industrial robot controller operational procedure generating module is built, an actual controller executable file is generated and lead out so as to be operated in an actual robot controller, and industrial robot off-line programming can be achieved. The method can achieve off-line programming operation rapidly and generate optimal gesture of corresponding points automatically, time for generating training data is short, and a space curve trail can be achieved conveniently and rapidly, wherein a basis of the space curve trail is difficult to find in reality to conduct teaching.