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296 results about "High throughput analysis" patented technology
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The High Throughput Analysis Laboratory (HTA) provides researchers with equipment and expertise for the development and execution of high throughput biological analysis and screening. The facility is equipped with state-of-the-art liquid handling, plate detection and automated microbial culture handling capabilities.
Methods and apparatuses for analyzing polynucleotide sequences
Owner:CALIFORNIA INST OF TECH
Microfluidic device and methods of using same
ActiveUS20050019792A1Prevent evaporationBioreactor/fermenter combinationsBiological substance pretreatmentsTemperature controlGenotyping
A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
Owner:STANDARD BIOTOOLS INC
Perfused three-dimensional cell/tissue disease models
ActiveUS20050260745A1Easy to primeBioreactor/fermenter combinationsBiological substance pretreatmentsLymphatic SpreadPathology diagnosis
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
Owner:MASSACHUSETTS INST OF TECH +1
Microfluidic devices and methods of using same
ActiveUS7666361B2Prevent evaporationHeating or cooling apparatusMicrobiological testing/measurementTemperature controlElastomer
A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
Owner:STANDARD BIOTOOLS INC
Optimized high throughput analytical systems
InactiveUS20060062696A1Reduce rateReduce the average velocityAnalysis using chemical indicatorsTransportation and packagingEngineeringMechanical engineering
Owner:CAPLIPER LIFE SCI INC
Methods of macromolecular analysis using nanochannel arrays
ActiveUS20080242556A1Microbiological testing/measurementLibrary screeningGenomic DNABiomarker (petroleum)
Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
Owner:BIONANO GENOMICS
Integrated high throughput system for the mass spectrometry of biomolecules
InactiveUS6783672B2Bioreactor/fermenter combinationsMaterial nanotechnologyDead volumeMass Spectrometry-Mass Spectrometry
Owner:INTRINSIC BIOPROBES
Browsable database for biological use
The browsable database can allow for high-throughput analysis of protein sequences. One helpful feature may be a simplified ontology of protein function, which allows browsing of the database by biological functions. Biologist curators may have associated the ontology terms with Hidden Markov Models (HMMs), rather than individual sequences, so that they can be applied to additional sequences. To ensure accurate functional classification, HMMs may be constructed not only for families, but for curator-defined subfamilies, whenever family members have divergent functions or nomenclature. Multiple sequence alignments and phylogenetic trees, including curator-assigned information, can be available for each family. Various versions of the browsable database may include training sequences from all organisms in the GenBank non-redundant protein database, and the HMMs can be used to classify gene products across the entire genomes of human, and Drosophila melanogaster.
Owner:APPL BIOSYSTEMS INC
Microfluidic Cell Trap and Assay Apparatus for High-Throughput Analysis
ActiveUS20150018226A1Easy to washImprove performanceHeating or cooling apparatusMicrobiological testing/measurementFlow cellTrapping
Microfluidic devices are provided for trapping, isolating, and processing single cells. The microfluidic devices include a cell capture chamber having a cell funnel positioned within the cell capture chamber to direct a cell passing through the cell capture chamber towards one or more a cell traps positioned downstream of the funnel to receive a cell flowing. The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of the contents of a captured cell. Methods for cell capture and preparation are also provided that include flowing cells through a chamber, funneling the cells towards a cell trap, capturing a predefined number of the cells within the trap, interrupting the flow of cells, flowing a wash solution through the chamber to remove contaminants from the chamber, and sealing the predefined number of cells in the chamber.
Owner:THE UNIV OF BRITISH COLUMBIA
Methods and apparatuses for analyzing polynucleotide sequences
InactiveUS20050014175A1Fixed microstructural devicesVolume/mass flow measurementPolynucleotideBiology
Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
Owner:CALIFORNIA INST OF TECH
High throughput profiling of methylation status of promoter regions of genes
InactiveUS20070161029A1Improve the level ofLower Level RequirementsMicrobiological testing/measurementFermentationDiseaseDNA
Rapid, sensitive, reproducible high-throughput methods for detecting methylation patterns in samples of nucleic acid, especially in the promoter region of genes which are enriched with CpG islands, are provided. The methods include isolating complexes of methylated DNA and methylation binding protein, optionally amplifying the isolated methylated DNA, and detecting the methylated DNA or its amplification products in a multiplex and robust manner. By using the inventive methodology, methylated and unmethylated sequences present in the original sample of nucleic acid can be distinguished. By profiling and comparing the methylation status of genes in different samples, one can utilize the information for diagnosis and treatment of diseases or conditions associated with aberrant DNA hypermethylation or hypomethylation.
Owner:PANOMICS
Method for improved plant breeding
InactiveUS20110167721A1Quick analysisAvoid prolonged exposureGrain huskingGrain polishingGenotypeBreeding program
The invention relates generally to an improved plant breeding system. More particularly, this invention relates to a method for automated, high throughput analysis of plant phenotype and plant genotype in a breeding program.
Owner:BASF PLANT SCI
Methods for conducting assays for enzyme activity on protein microarrays
The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and / or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.
Owner:LIFE TECH CORP
Parallel patch clamp system
ActiveUS20060194255A1Increase success rateLow costImmobilised enzymesBioreactor/fermenter combinationsCurrent sensorEngineering
A system for high-throughput analysis of membranous samples having ion channels including at least one membranous sample, a multi-compartment structure including an extracellular chamber, an opposing intracellular chamber and a partition separating the extracellular and intracellular chambers, the partition having a plurality of apertures fluidly and electrically coupling the extracellular and intracellular chambers, wherein at least one of the apertures is sealed by the at least one membranous sample, and another of the apertures is unsealed, a electric source configured to apply a current between the extracellular and intracellular chambers, wherein a portion of the current travels through the unsealed aperture, and a current sensor configured to measure the current between the extracellular and intracellular chambers. A method of using the system is also disclosed.
Owner:MOLECULAR DEVICES
Multiplex labeling of molecules by sequential hybridization barcoding
ActiveUS20150267251A1Reduce development riskSlow onsetOptical radiation measurementLibrary screeningBiological bodyOrganism
The present invention, among other things, provides technologies for detecting and / or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and / or DNA loci.
Owner:CALIFORNIA INST OF TECH
Integrated high throughput system for the mass spectrometry of biomolecules
InactiveUS20020094566A1Bioreactor/fermenter combinationsMaterial nanotechnologyDead volumeMicro column
Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.
Owner:INTRINSIC BIOPROBES
Methods of macromolecular analysis using nanochannel arrays
ActiveUS8722327B2Bioreactor/fermenter combinationsBiological substance pretreatmentsMolecular analysisGenomic DNA
Owner:BIONANO GENOMICS
Multiplex labeling of molecules by sequential hybridization barcoding
ActiveUS10457980B2Introduce significant noise ad biasLimited in numberSugar derivativesMicrobiological testing/measurementBiological bodyBarcode
Owner:CALIFORNIA INST OF TECH
Method and primers for detecting mi ribonucleic acid (miRNA) and application of method
ActiveCN102154505AIncreased sensitivityImprove featuresMicrobiological testing/measurementDNA/RNA fragmentationForward primerDisease
The invention discloses a method and primers for detecting mi ribonucleic acid (miRNA) and application of the method. The method comprises the following steps of: performing reverse transcription on the miRNA in a sample by using a reverse transcription primer formed by specific basic groups and Oligo (dT); and performing real-time polymerase chain reaction (PCR) quantitative detection on the miRNA by using a specific forward primer, a general reverse primer and a general probe. The invention has the characteristics that: the sensitivity and the specificity of the method are obviously higher than those of the conventional method; high-throughput analysis can be performed; and the method is simply and quickly operated, is low in cost, and can be widely used for early diagnosis and prediction of critical diseases such as tumors and the like.
Owner:苟德明 +1
Image-based automated measurement model to predict pelvic organ prolapse
ActiveUS20160275678A1Reduce noiseImprove understandingImage enhancementImage analysisClinical informationPelvic diaphragm muscle
A system and methodology for the automated localization, extraction, and analysis of MRI-based features with clinical information to improve the diagnosis of pelvic organ prolapse (POP). The system can automatically identify reference points for pelvic floor measurements on MRI rapidly and consistent. It provides a prediction model that analyzes the correlation between current and new MRI-based features with clinical information to differentiate patients with and without POP. This system will enable the high throughput analysis of MR images for their correlation with clinical information to better detect POP. The presented system can also be applied to the automated localization and extraction of MRI features for the diagnosis of other diseases where clinical examination is not adequate.
Owner:UNIV OF SOUTH FLORIDA
High throughput multi-dimensional sample analysis
High throughput analytical systems and methods employing multiple liquid phase separation process regions coupled to a common mass spectrometer are provided. Disclosed systems and methods permits parallel separation and parallel storage of discrete eluate fractions, followed by sequential discharge and ionization of previously stored eluate portions to yield a composite ion stream containing the sequential series of eluate portions, followed by mass analysis of the ion stream. A common manifold may receive ions and utilize pressurized gas or ion gating to direct ions within the manifold toward the mass spectrometer inlet.
Owner:AGILENT TECH INC
System, device and method for high-throughput multi-plexed detection
The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.
Owner:YALE UNIV
Multiplex labeling of molecules by sequential hybridization barcoding using probes with cleavable linkers
InactiveUS20160369329A1Introduce significant noise ad biasLimited in numberMicrobiological testing/measurementDNA preparationBiological bodyBarcode
The present invention, among other things, provides technologies for detecting and / or quantifying nucleic acids in cells, tissues, organs or organisms. Through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and / or DNA loci. In some embodiments, nucleic acid probes include a signal moiety connected with a binding sequence via a cleavable linker.
Owner:CALIFORNIA INST OF TECH
Microfluidic devices and methods facilitating high-throughput, on-chip detection and separation techniques
InactiveUS7744762B2Convenient investigationFacilitating analyte detectionIon-exchange process apparatusSamplingAnalyteSeparation technology
Owner:VIRGINIA TECH INTPROP INC
Method for screening malignant ovarian tumor markers from blood serum metabolic profiling
InactiveCN101769910AReduce human errorAvoid human errorComponent separationBiological testingMultivariate statisticsScreening method
The invention discloses a method for screening malignant ovarian tumor markers according to blood serum metabolic profiling. In the method, the Ultra Performance Liquid Chromatography-mass spectrometry technology is employed to analyze blood serum to obtain blood serum metabolic profiling; then the multivariate statistics method is employed to analyze data concerning malignant ovarian tumor and blood serum metabolic profiling of healthy people, so as to screen maker spectrums. The screening method of the invention features good repeatability and good forecasting property of the screened markers. Proven by discriminant classification analysis, the screening method enjoys an average forecasting precision rate of 90.90% and a positive relevance ratio of 82.65%.The maker spectrum covering multiple compounds can be obtained in a single analysis, which indicates that the marker is suitable for high flux analysis and enjoys the prospect of being promoted to large-scale sample screening and clinical application.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI +4
Methods and compositions relating to 5'-chimeric ribonucleic acids
InactiveUS20040220127A1Prevent cryptic aberrant trans-splicing reactionLittle effectMicrobiological testing/measurementGenetic material ingredientsChimeric RNAHigh throughput analysis
The disclosure provides, among other things, methods for producing and using 5'-chimeric RNAs and cDNAs. 5'-chimeric RNAs and cDNAs may be used, for example, for high-throughput analysis of the 5'-end sequences for RNA transcripts.
Owner:CALIFORNIA INST OF TECH
Mass spectrometer and method of mass spectrometry
InactiveUS20110204221A1Prevent ion lossExtended reaction timeTime-of-flight spectrometersIsotope separationIon trap mass spectrometryIon dissociation
When a high-speed analyzer such as a quadrupole mass filter is united with an analyzer which requires a reaction time of 10 msec, such as an ion dissociation chamber of the ion trap type, a problem arises that an ion loss occurs due to a difference in analysis speed between the analyzers. A high-throughput analysis is intended to be achieved by eliminating this loss. A pre ion trap (4) is provided between a quadrupole filter (3) and an ion dissociation chamber (5), and ions are accumulated in the pre ion trap (4) while operations such as dissociation, isolation and ejection are being performed in the ion dissociation chamber (5). This configuration solves a problem with the ion dissociation chamber (5), which is a decrease in transmittance of the dissociation chamber (5), i.e., a decrease in throughput, and accordingly enables a high-throughput structural analysis on a measurement sample.
Owner:HITACHI LTD
Microcolumn-platform based array for high-throughput analysis
InactiveUS7332328B2Promote biological responseIncreases microfluidic interactionBioreactor/fermenter combinationsBiological substance pretreatmentsMicro columnEngineering
A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.
Owner:CORNING INC
Multifunctional encoded particles for high-throughput analysis
Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
Owner:MASSACHUSETTS INST OF TECH
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