Method for screening malignant ovarian tumor markers from blood serum metabolic profiling

A metabolic profile and ovarian tumor technology, applied in the field of screening of gynecological malignant ovarian tumor serum small molecule metabolic marker profiles, can solve the problems of easy introduction of errors in serum and difficulty in modeling, achieving simple process, saving analysis time, and resolution. high effect
CN101769910AInactive Publication Date: 2010-07-07DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI +4
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Publication Date
2010-07-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for screening malignant ovarian tumor markers according to blood serum metabolic profiling. In the method, the Ultra Performance Liquid Chromatography-mass spectrometry technology is employed to analyze blood serum to obtain blood serum metabolic profiling; then the multivariate statistics method is employed to analyze data concerning malignant ovarian tumor and blood serum metabolic profiling of healthy people, so as to screen maker spectrums. The screening method of the invention features good repeatability and good forecasting property of the screened markers. Proven by discriminant classification analysis, the screening method enjoys an average forecasting precision rate of 90.90% and a positive relevance ratio of 82.65%.The maker spectrum covering multiple compounds can be obtained in a single analysis, which indicates that the marker is suitable for high flux analysis and enjoys the prospect of being promoted to large-scale sample screening and clinical application.
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Description

technical field

[0001] The invention relates to the fields of analytical chemistry and medicine, and is a new method for screening the serum small molecule metabolic marker profile of gynecological malignant ovarian tumors based on the serum metabolic profile of metabonomics technology. Background technique

[0002] Ovarian cancer, endometrial cancer, and cervical cancer are collectively known as the "three gynecological cancers". The incidence of the first two continues to rise, and the proportion of glandular epithelial types of cervical cancer is also increasing, which is seriously endangering women's health. General physical examination and imaging examinations have limited effects, and by the time they can be discovered and diagnosed, it is often in the middle or late stage, lacking early warning value. In the study of ovarian malignant tumors, commonly used serum markers are: CA125 (cancer antigen 125), squamous cell carcinoma antigen, CEA (carcinoembryonic antigen). ...

Claims

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