A logistics distribution bill generating method based on a two-dimension code and an encryption technology includes the following steps that A1, required basic information of an original express distribution bill is obtained, and an express bill number is automatically generated; A2, the symmetric encryption algorithm AES algorithm is adopted for encrypting the related information of the original express distribution bill, and the process includes the steps that (1), 128-bit data are grouped; (2), xor calculation of an and expansion secrete key is performed; (3), S box transformation is performed; (4), row transformation is performed; (5), column transformation is performed; (6), xor is performed in the and expansion secrete key; (7), S box transformation is performed; (8), row transformation is performed; (9), xor is performed on the and expansion secrete key; (10), the 128-bit data are output; A3, a two-dimension code express distribution bill is generated through a two-dimension code generator. The distribution efficiency and safety degree of logistics can be improved.