The invention provides an encryption method and device using a random clock based on chaos, and belongs to the field of information safety. According to the system, a design scheme which is integrated from top to bottom is adopted. The device is composed of a crystal oscillator, a PLL1, a PLL2, a pseudorandom sequence generating module, a chaotic mapping control module, a disturbance generating module, a clear text input module, an encryption module, a secret key extension module and a cipher text output module. According to the encryption method and device using the random clock based on chaos, a common linear feedback shift register, chaotic mapping control and cipher text feedback are combined to generate the random clock, the safety of the random clock is effectively improved, and power attack and electromagnetism attack can be effectively resisted. The encryption method and device using the random clock based on chaos can be applied to industrial and technical production of encrypted hardware storage device static encryption, microwave or photo-communication chains, and a receiving or transmitting port of a computer terminal and the like.