The invention discloses a parameterized customization method and device for an organ conformal paper-
cut structure. The method comprises the steps that S1, a 3D model of a
target organ is constructed, and
Gaussian curvature distribution of the surface of the
target organ is obtained; s2, extracting the feature curvature of a target area with the highest surface curvature in the
target organ; and S3, constructing an equivalent sphere model for parameterization design of the paper-
cut structure by utilizing the characteristic curvature K, and obtaining geometric structure parameters of the inlaid paper-
cut unit according to a preset threshold value of the effective
area coverage rate and by combining a conformal theory, so that the paper-cut structure and the target organ are conformal, and the effective
area coverage rate reaches the preset threshold value. According to the method, geometric structure parameters of inlaid paper-cut units are optimized, so that each unit is subjected to self-adaptive deformation according to the local curvature of the
organ surface, seamless attachment of the paper-cut structure on the complex
organ surface is ensured, the effective
area coverage rate is as high as 95%, and the uniformity and efficiency of
drug delivery and the electrotransfection depth are improved.