Blocking material capable of stopping bleeding, preparation method thereof, and blocking product capable of stopping bleeding

A technology of plugging materials and fiber raw materials, which is applied in the fields of pharmaceutical formulation, application, and medical science. It can solve the problems of unsatisfactory hemostasis speed and hemostatic volume, difficult to heal, and poor adhesion, and achieve excellent adhesion and water absorption. , good biocompatibility, high safety effect

Active Publication Date: 2018-11-13
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Based on the above-mentioned technical problems in the prior art, for example: the adhesion is poor, and it is easy to fall off from the wound; the temperature around the wound is raised to cause a burn wound,

Method used

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  • Blocking material capable of stopping bleeding, preparation method thereof, and blocking product capable of stopping bleeding

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Effect test

no. 1 approach

[0044] Such as figure 1 As shown, in the first embodiment of the present invention, a hemostatic plugging material is provided, including: a base body 1, the base body 1 includes non-woven fiber filaments, and the linear density of the non-woven fiber filaments is 0.5dtex-5dtex , the degree of carboxylation is 12% to 25%; and there is a wet adhesion layer 2 on at least one surface of the substrate 1, and the wet adhesion layer 2 is formed by contacting at least one surface of the substrate 1 with an adhesion solution. get.

[0045]The saturated water absorption rate of the hemostatic plugging material of the present invention is between 400%-2000%, for example: it can be 600%-1800%, it can be 800%-1600%, it can be 1000%-1400% and so on. The hemostatic plugging material can quickly absorb the moisture in the blood, and still has adhesiveness after absorbing the moisture, and will not be washed away or penetrated. Therefore, the hemostatic plugging material of the present inv...

no. 2 approach

[0070] In the second embodiment of the present invention, a method for preparing a hemostatic occlusion material is provided, including the step of composite molding the base body and the wet adhesive layer, wherein,

[0071] The matrix includes non-woven fiber filaments, the linear density of the non-woven fiber filaments is 0.5dtex-5dtex, and the degree of carboxylation is 12%-25%;

[0072] The wet adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution;

[0073] The adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer.

[0074] In the present invention, the substrate may be ready-made, or the pre-prepared finished substrate may be directly compounded with the wet adhesive layer.

[0075] In the present invention, the preparation method of the matrix includes: after oxidizing the fiber raw material, processing and shaping it by using a non-woven process. Through oxidati...

no. 3 approach

[0097] In the third embodiment of the present invention, a hemostatic occlusion product is provided, including the hemostatic occlusion material according to the first embodiment, or the hemostatic occlusion material obtained according to the preparation method of the hemostatic occlusion material according to the second embodiment .

[0098] In the hemostatic occlusion product of the present invention, optionally, there is a backing layer on the side of the substrate that does not have the wet-state adhesive layer, and a peelable layer on the wet-state adhesive layer. In the present invention, the purpose of setting the peelable layer may be to keep the wet adhesive layer with a certain humidity and not be affected by other substances. The present invention does not specifically limit the materials of the backing layer and the peelable layer, as long as they do not affect the function of the hemostatic occlusion product of the present application.

[0099] The hemostatic plu...

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Abstract

The invention provides a blocking material capable of stopping bleeding, a preparation method thereof, and a blocking product capable of stopping bleeding. The blocking material comprises a matrix, and a wet state adhesive layer which is arranged on at least one surface of the matrix; the matrix comprises nonwoven fiber filament; the linear density of the nonwoven fiber filament ranges from 0.5dtex to 5dtex, and the carboxylation degree ranges from 12 to 25%; the wet state adhesive layer is obtained through contact of at least one surface with an adhesive solution; the adhesive solution contains an amino compound and a buffer solution; the amino compound is dissolved in the buffer solution. The blocking material possesses excellent adhesion performance and water adsorption performance, iscapable of realizing effective adhesion with organism surfaces or parenchyma organ surfaces, and can be degraded and absorbed; deposition in internal organs is avoided; internal organs function damageis not caused; and the blocking material is safe to be used for stopping bleeding.

Description

technical field [0001] The invention relates to a hemostatic plugging material, a preparation method thereof and a hemostatic plugging product, belonging to the field of medical implant materials. Background technique [0002] Hemostatic blockage is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. Effective hemostasis is the key to relieving patients' suffering and reducing mortality, and rapid and effective hemostasis has become the focus of solving this problem. In daily life, it is inevitable to encounter damage to body tissues caused by various unexpected accidents and disasters. [0003] At present, common hemostatic materials include microporous inorganic materials (zeolites), microporous starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostatic gauze, α-cyanoacrylate tissue glue, etc. Although there is a good hemostatic effect, ...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/0015A61L24/0036A61L24/0042A61L24/08A61L24/102A61L24/108A61L2400/04
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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