16 results about "Organ cavity" patented technology

A catheter includes a shaft having a distal-end and an expandable distal-end assembly configured for insertion into a cavity of an organ of a patient. The expanded assembly defines an inner volume and includes (i) a proximal base section configured to couple the assembly to the shaft's distal-end, (ii) a plurality of functional electrodes that are at least partially external to the inner volume and configured to be placed in contact with wall tissue of the cavity, and (iii) a reference ring electrode located on the proximal base section of the assembly externally to the inner volume, wherein the reference ring electrode is selectively positioned outside of the inner volume at the base section, and wherein the reference ring electrode is configured to be coupled with each of the plurality of functional electrodes for generating an electric field between each of the plurality of functional electrodes and the ring electrode.

To provide a system and method for ventilating an organ.SOLUTION: Provided are a system and method for maintaining vitality of an organ (1029) ex vivo, such as a lung, through negative pressure ventilation (NPV) and perfusion. The system includes fluidically coupled components: an organ enclosure (107), a diaphragm enclosure (109), an actuator / pump (105), a valve (112), a reservoir (103), and a perfusion system. The actuator can displace a precise amount of a working fluid that displaces a precise amount of a sterile support fluid. The sterile fluid travels between the diaphragm enclosure and the organ enclosure, thereby ventilating the organ within an organ chamber. The perfusion system circulates a perfusion fluid through the organ.SELECTED DRAWING: Figure 1

A method includes monitoring impedances of the plurality of the functional electrodes relative to a reference electrode while maneuvering a catheter within a cavity of an organ, the catheter comprising (i) a shaft having a distal end, and (ii) an expandable distal-end assembly coupled to the distal end of the shaft and comprising a plurality of functional electrodes. A direction vector is estimated from the monitored impedances, along which the catheter is free to advance within the cavity of the organ without obstruction by the tissue wall. The direction vector is displayed to a user.

A system includes a catheter and a processor. The catheter includes a distal-end assembly coupled to a distal end of a shaft for insertion into a cavity of an organ of a patient, the distal-end assembly including (i) one or more functional electrodes configured to be placed in contact with wall tissue of the cavity and (ii) a reference electrode configured to be placed in the cavity but not in contact with the wall tissue. The processor is configured to (i) estimate one or more impedances between one or more of the functional electrodes and the reference electrode, and (ii) based on the impedances, determine, for at least a functional electrode from among the one or more functional electrodes, whether the functional electrode is in physical contact with the wall tissue.

The invention belongs to the field of micro-physiological systems, and discloses a human body micro-physiological system based on whole hPSC. Three-dimensional modeling is carried out according to the relative positions and sizes of the organs in the human body, partitioning is carried out according to different areas of the human body, the brain chamber is located in the cranial cavity area, the heart and double lung chambers are located in the thoracic cavity area, and the liver and double kidney chambers are located in the abdominal cavity area. The lung chambers are arranged on the two sides of the heart, the liver is arranged on the right of the front upper portion of the abdominal cavity area, and the kidney chambers are arranged on the rear lower portion, the left portion and the right portion of the abdominal cavity area and distributed in a splayed mode. Due to the fact that printing of a whole human body chip cannot be achieved through an existing 3D printing technology, and openness of all cavities needs to be reserved to facilitate cell loading, the strategy that 3D printing is conducted according to modules is adopted, and nine bionic modules including a head top module, a cranial cavity module, a thoracic cavity module, an abdominal cavity module, a hip-leg module, a forearm module and a shank module are included. And by adopting a double-channel design, all organ chambers are connected together, so that the information exchange of all organs is promoted.

A system includes a catheter and a processor. The catheter includes (i) a shaft for insertion into a cavity of an organ of a patient, (ii) an expandable distal-end assembly coupled to a distal end of the shaft and comprising splines fitted with spline-electrodes, (iii) a proximal position sensor and a respective proximate proximal electrode located both at a proximal end of the distal-end assembly, and (iv) an independent wire that extends at the distal tip, with a distal position sensor and a respective proximate distal electrode located both at a distal end of the independent wire. The processor is configured to estimate locations of one or more of the spline-electrodes by performing impedance measurements on the one or more of the electrodes, and to calibrate the impedance measurements based on signals received from the proximal position sensor and the distal position sensor and the respective proximal and distal electrodes.

A multi-layer balloon membrane material (1) is described, which combines one or several layers of elastically deformable material (2) with one or several layers of plastically deformable, inelastic material (3), wherein the inelastic layers counteract the straightening properties of the elastic layers in the case of planar folding or bending of the balloon membrane material. In particular, the cross-sectional area of the eye- or channel-like structures (6) for guiding secretions or liquids, which are typically produced in the region of the plicated invagination of the balloon membrane with dimensional redundancy in organ cavities or body cavities, can be reduced, and in particular stabilized in the case of a periodic change in the balloon filling pressure, whereby an optimal sealing closure or packing result is achieved over as large a range of filling pressure amplitudes as possible.

A system includes a catheter and a processor. The catheter includes a distal-end assembly coupled to a distal end of a shaft for insertion into a cavity of an organ of a patient, the distal-end assembly including (i) one or more functional electrodes configured to be placed in contact with wall tissue of the cavity and (ii) a reference electrode configured to be placed in the cavity but not in contact with the wall tissue. The processor is configured to (i) estimate one or more impedances between one or more of the functional electrodes and the reference electrode, and (ii) based on the impedances, determine, for at least a functional electrode from among the one or more functional electrodes, whether the functional electrode is in physical contact with the wall tissue.

To map a cavity.SOLUTION: A method is provided, consisting of acquiring data representative of a volume of a cavity of an organ, presenting on a display an electroanatomical (EA) map of a surface, generated in response to the data, enclosing the volume, and receiving input from a user, the input including a selected section of the EA map. The method includes, in response to the user input, locking a portion of the volume to subsequent updates of the data when updating the EA map, the portion of the volume consisting of the selected section of the EA map.SELECTED DRAWING: Figure 1

A device for introducing a VAC therapy sponge into an area of interest comprises a porous polyurethane sponge 1 for aspirating pathological secretion through an organ cavity, and a drainage tube 2, the sponge 1 being fastened to the end of the drainage tube 2. The device is characterized in that it further comprises a flexible metal guide wire 3 mounted in the drainage tube 2, a silicon tube 4 intended to encompass the compressed sponge 1, and a thread 5 compressing the sponge, said thread 5 having a knot 6 thereon which self-releases when the end 7 of the thread is pulled. The invention makes it possible to position a VAC therapy sponge in an area of interest when treating a gastrointestinal anastomotic leak using a vacuum aspirator system, while assuring compression of the entire sponge.

Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the bioartificial airway organs. The bioreactor comprises: an organ chamber: an ingres line connecting the organ chamber and a reservoir system and comprising an arterial line, a venous line and a tracheal line; an egress line connecting the chamber and the reservoir system, pumps in ingress and egress lines; a controller to control fluid exchange; a chamber pressure sensor connected to the organ chamber.

A method includes receiving time-varying boundary condition values measured for a probe inside a cavity of an organ of a patient. A time-dependent shape of the probe is calculated by (a) representing sections of the probe as first springs, (b) representing external forces acting on the sections as second springs, and (c) solving a set of coupled equations of motion, for the first springs and the second springs, so as to meet the time-varying boundary condition values. The shape is presented to a user.

A system and method for maintaining the vitality of an organ through negative pressure ventilation and perfusion. The system includes fluidically coupled components: an organ enclosure, a diaphragm enclosure, an actuator / pump, a perfusion system, and a reservoir. The actuator can displace a precise amount of a working fluid that displaces that precise amount of a sterile support fluid. The sterile fluid travels between the diaphragm enclosure and the organ enclosure, thereby ventilating the organ within the organ chamber. The perfusion system circulates a perfusate through the organ.

The invention describes a multilayer balloon membrane material (1) which combines one or several layers of elastically deformable material (2) with one or several layers of plastically deformable, inelastic material (3), wherein the inelastic layers counteract the straightening properties of the elastic layers in the case of planar folding or bending of the balloon membrane material. In particular, the cross-sectional area of the eye- or channel-like structures (6) for guiding secretions or liquids, which are typically produced in the region of the plicated invagination of the balloon membrane with dimensional redundancy in organ cavities or body cavities, can be reduced, and in particular stabilized in the case of a periodic change in the balloon filling pressure, whereby an optimal sealing closure or packing result is achieved over as large a range of filling pressure amplitudes as possible.

The present application discloses a kind of pipe anastomat with retractable nail seat, to solve the problem that existing pipe anastomat cannot realize minimally invasive surgery, thereby leading to large surgical wound, long recovery time, increase patient's pain and other problems.The present application includes retractable nail seat, nail seat opening mechanism, anastomosis firing mechanism;Nail seat can be connected with nail seat opening mechanism to form implantation mechanism assembly, when nail seat is in the state of contraction, it can make nail seat pass through minimally invasive artificial hole, puncture through organ cavity wall, so that nail seat enters the organ cavity to be connected, then operate nail seat opening mechanism to realize nail seat expansion;Anastomosis firing mechanism and nail seat are connected to form anastomat assembly, which completes the nail anastomosis between cavities, excess tissue resection and cavity channel reconstruction in living organisms.The present application realizes the channel reconstruction operation of pipe anastomat in minimally invasive surgery environment, which makes the operation have small wound, short recovery time, reduces patient's pain and other advantages.

A system and method for maintaining the vitality of an organ through negative pressure ventilation and perfusion. The system includes fluidically coupled components: an organ enclosure, a diaphragm enclosure, an actuator / pump, a perfusion system, and a reservoir. The actuator can displace a precise amount of a working fluid that displaces that precise amount of a sterile support fluid. The sterile fluid travels between the diaphragm enclosure and the organ enclosure, thereby ventilating the organ within the organ chamber. The perfusion system circulates a perfusate through the organ.