Method for determining one content in protein and associated devices and methods

A protein content and determination method technology, applied in the field of determining at least one protein content, can solve problems such as poor measurement, difficult implementation of equipment, and accuracy

Pending Publication Date: 2021-07-23
INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the methods and devices of these documents are not easy to implement and the measurements provided may not be as accurate as desired

Method used

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  • Method for determining one content in protein and associated devices and methods
  • Method for determining one content in protein and associated devices and methods
  • Method for determining one content in protein and associated devices and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0085] Description of the device

[0086] exist figure 1 The device 10 is shown on.

[0087] The device 10 is a device suitable for determining the amount of at least one protein in a biological sample.

[0088] Apparatus 10 includes at least one container 12 , spectrophotometer 14 , dosing material 16 and analysis system 18 .

[0089] At least one container 12 contains a biological sample 20 to be analyzed.

[0090] Biological sample 20 is a sample from a subject.

[0091] The subject is an animal, such as a mammal, like a mouse, a monkey or a human.

[0092] As used herein and according to all aspects of the invention, the term "sample" means blood, fresh whole blood, peripheral blood, peripheral blood mononuclear cells (PBMC), serum, plasma or urine.

[0093] Sample 20 includes several proteins, including oxyhemoglobin, methemoglobin, heme bound to serum albumin, heme bound or free hemopexin, and bilirubin.

[0094] Oxyhemoglobin specifies the reduction of hemoglobin ...

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Abstract

The present invention aims at providing a method for determining at least one protein in the blood which is more precise while still being simple to implement. The inventors have exploited in an original way the spectroscopy and the dosing techniques to determine accurately the content in proteins of the biological sample, notably for oxyhemoglobin, methemoglobin, heme bound to serum albumin and hemopexin and bilirubin. Such method can advantageously be used in various applications concerning heme-related or hemoprotein-related disorders, notably method for diagnosing, for following a treatment, for determining biomarkers or for screening. Such a method is also interesting for qualifying blood bags.

Description

technical field [0001] The present invention relates to a method for determining (determining) the content of at least one protein. The invention also relates to methods for diagnosing heme-related or heme protein-related disorders. The present invention also relates to methods for identifying therapeutic targets for the prevention and / or treatment of heme-related or heme protein-related disorders. The present invention also relates to methods for identifying biomarkers that are diagnostic biomarkers for heme-related or heme protein-related disorders, susceptibility biomarkers for liver disease, heme-related Or a prognostic biomarker for a heme protein-associated disorder, or a predictive biomarker for response to treatment of a heme-associated or heme protein-associated disorder. The present invention also relates to methods for screening pharmaceutically useful compounds that act on known therapeutic targets for the prevention and / or treatment of heme-related or heme prote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
CPCG01N21/31G01N21/75G01N33/72
Inventor 劳伦特·基热巴勃罗·巴尔托卢奇迈克尔·马登
Owner INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
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