Oxygen-transferring blood substitute and a pharmaceutical composition (variants)

A technology of blood substitutes and compositions, applied in the field of pharmaceuticals, which can solve the problems of high content of tetramers and methaemoglobin, changes in hemoglobin concentration, and limitations

Inactive Publication Date: 2011-04-20
麦德佰欧法姆有限公司俄罗斯联邦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The disadvantage of this blood substitute is the high content of tetramer and methaemoglobin
At this point, the possibility to change the hemoglobin concentration in the solution is limited, and changes in the solvent composition are not possible

Method used

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  • Oxygen-transferring blood substitute and a pharmaceutical composition (variants)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Stabilized bovine blood cooled to +2 to +4°C is placed in 10 liter plastic containers in a total volume of 30 liters and transferred from the cold room to the workshop via the tunnel. Blood is injected into the receiver of the operating separator AI-FMC with the assistance of a peristaltic pump. Separation was performed at 4000 rpm. The resulting body of erythrocytes in an amount of 12 liters was injected into the hemolysis reaction vessel.

[0029] After placing 12 liters of red blood cell material into the biodegradable Flexel 3D biobag (E1) with a capacity of 50 liters for hemolysis (all containers are equipped with a cooling jacket), turn on the peristaltic pump for stirring, and then collect from the solution preparation room. To the tank, add 36 liters of water for injection (BIA) at a temperature of +6 to +8°C (temperature controlled by a sensor in the pallet tank). The hemolysis reaction was carried out under stirring within 40 minutes.

[0030] Th...

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Abstract

The invention relates to medicine, in particular to polyhemoglobin-based blood substitutes. The invention can be used for producing blood substituting solutions comparable in terms of a gas transportation efficiency (oxygen transfer) with human blood erythrocytes. The inventive oxygen-transferring blood substitute is based on the hemoglobin which is polymerised by glutaraldehyde produced from animal blood and differs in that it is in the form of a dry substance and contains not less than 90% of polymerised hemoglobin, the molecular mass of which ranges from 192 000 to 320 000 Da and the methemoglobin content in the blood substitute is equal to or less than 5%.

Description

technical field [0001] The present invention relates to pharmaceuticals, namely blood substitutes based on polymerized hemoglobin. The present invention can be used to prepare a blood substitute solution whose gas transport (oxygen transport) efficiency is comparable to that of human red blood cells. Background technique [0002] Blood substitutes for polymerized hemoglobin (L.R. Sehgal, A.L. Rosen, S.A. Gould, H.L. Sehgal, G.S. Moss / Transfusion.-1983.-V.23.-N 2.-P.158-162) are well known. [0003] The main drawback of the known blood substitutes is their high cost due to the use of the expensive bioactive agent pyridoxal-5-phosphate (PF) in the blood substitutes. And the final product contains free PF and is dangerous, which may lead to adverse consequences. [0004] There is also a well-known blood substitute Gelenpol (RU 2132687, A61K35 / 18, A61K38 / 42, 1999), which is a mixture of hemoglobin tetramers and oligomers of different chain lengths. Oligomers are obtained by c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/42C07K14/805A61P7/00
CPCA61K38/42A61K9/0026A61P7/00
Inventor 安娜·杨科夫莱夫纳·贡恰罗娃弗拉迪米尔·康斯坦丁诺维奇·波德戈罗德尼凯恩克拉希姆德然·艾哈迈德扎诺维奇·罗齐夫维克托·维拉迪米罗维奇·霍米切诺科阿纳托利·费奥多罗维奇·齐比奥尔加·鲍里索夫娜·布鲁斯科娃
Owner 麦德佰欧法姆有限公司俄罗斯联邦
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