Rapid preparation method and application of core-shell spherical magnetic mesoporous silica nanocomposites

A nanocomposite material, mesoporous silica technology, applied in the direction of silica, silicon oxide, iron oxide, etc., can solve the problem of difficult control of particle shape, size uniformity, dispersion, and size uniformity of magnetic nanoparticles. Controlling, difficult to achieve highly dispersed nanoparticles and other problems, to achieve the effect of enhancing the effect of nuclear magnetic imaging, large drug loading capacity, and improving the effect of diagnosis and treatment

Inactive Publication Date: 2015-11-25
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In recent years, people have made a lot of progress in the synthesis and application of magnetic mesoporous silica composite nanomaterials, but there are still some problems: the size uniformity of magnetic nanoparticles with core-shell structure is difficult to control, and it is not easy to achieve the applic

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Embodiment 1

[0036] Example 1: Preparation of core-shell spherical magnetic mesoporous silica nanocomposites

[0037] In 34mL of diethylene glycol (DEG) solution, add 0.576gPAA and 0.13gFeCl3, under the protection of nitrogen, stir and heat to 250 ° C, after 20 minutes, add 2.8 mL of 80 ° C sodium hydroxide (NaOH) in diethylene glycol solution (0.1 g / mL), stirred and reacted for 1 hour, the reaction product was magnetically separated, washed with water, and dried to obtain spherical magnetic ferrite nanoparticles (Fe 3 o 4 ). Weigh 10mgFe 3 o 4 Disperse in deionized water, add 100mg CTAB, add 0.4mL ammonia water after ultrasonication for 40 minutes, stir and heat to 40°C, slowly add 10μLTEOS dropwise, stir and react for 20 minutes; separate and purify the reaction product to obtain core-shell spherical magnetic mesoporous silica nanocomposites. It was dispersed in 100mL of 0.5% ammonium nitrate ethanol solution, stirred and heated to reflux three times to remove CTAB. A core-shell sphe...

Embodiment 2

[0038] Example 2: Preparation of core-shell spherical magnetic mesoporous silica nanocomposites

[0039] In 34 mL of diethylene glycol (DEG) solution, add 0.576 g of PAA and 0.13 g of FeCl 3 , stirred and heated to 250°C under the protection of nitrogen, after 20 minutes, 2.8mL of 80°C sodium hydroxide (NaOH) diethylene glycol solution (0.1g / mL) was added, and the reaction product was magnetically separated after stirring for 1 hour. Washed with water and dried to prepare spherical magnetic ferrite nanoparticles (Fe 3 o 4 ). Weigh 10mgFe 3 o 4 Disperse in deionized water, add 150mg CTAB, add 0.4mL ammonia water after ultrasonication for 40 minutes, stir and heat to 40°C, slowly add 15μLTEOS dropwise, stir and react for 20 minutes; separate and purify the reaction product to obtain core-shell spherical magnetic mesoporous silica nanocomposites. It was dispersed in 100mL of 0.5% ammonium nitrate ethanol solution, stirred and heated to reflux three times to remove CTAB. A ...

Embodiment 3

[0040] Example 3: Preparation of core-shell spherical magnetic mesoporous silica nanocomposites

[0041] In 34mL of diethylene glycol (DEG) solution, add 0.576gPAA and 0.13gFeCl3, under the protection of nitrogen, stir and heat to 250 ° C, after 20 minutes, add 2.8 mL of 80 ° C sodium hydroxide (NaOH) in diethylene glycol solution (0.1 g / mL), after stirring for 1 hour, the reaction product was magnetically separated, washed with water, and dried to prepare spherical magnetic ferrite nanoparticles (Fe 3 o 4 ). Weigh 10mgFe 3 o 4 Disperse in deionized water, add 200mg CTAB, add 0.5mL ammonia water after ultrasonication for 40 minutes, stir and heat to 40°C, slowly add 20μLTEOS dropwise, stir and react for 20 minutes; separate and purify the reaction product to obtain core-shell spherical magnetic mesoporous silica nanocomposites. It was dispersed in 100mL of 0.5% ammonium nitrate ethanol solution, stirred and heated to reflux three times to remove CTAB. A core-shell spheri...

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Abstract

The invention provides a rapid preparation method of core-shell spherical magnetic mesoporous silica nanocomposites. The invention also provides an application of the core-shell spherical magnetic mesoporous silica nanocomposites in diagnosis and treatment of tumors. According to the preparation method, spherical magnetic ferrite nanoparticles are prepared by an alkali hydrolysis method; and by using the spherical magnetic ferrite nanoparticles as seed particles and by the utilization of self-assembly behavior of a surfactant in an aqueous solution and an inorganic silicon source, the surface of the magnetic ferrite nanoparticles is rapidly coated with a layer of mesostructured silica nanocomposites so as to obtain the core-shell spherical magnetic mesoporous silica nanocomposites. The method is time-saving and reaction condition is pure water phase. By the method, a lot of the core-shell spherical magnetic mesoporous silica nanocomposites can be prepared within a short time.

Description

technical field [0001] The invention relates to the field of nanocomposite materials and technology, in particular to a rapid preparation method of a core-shell spherical magnetic mesoporous silica nanocomposite material. Background technique [0002] Due to their good biocompatibility, low toxic and side effects, and unique magnetic properties, magnetic nanoparticles have great potential in biomedical fields such as magnetic resonance imaging, immunoassays, targeted drug carriers, and separation of cells and biomolecules. It is favored by people because of its application prospect. At the same time, mesoporous silica nanomaterials have become ideal carriers in the fields of gene therapy, drug delivery, and medical imaging due to their advantages such as high specific surface area, high pore volume, uniform pore size, good biocompatibility, and easy surface modification. Among them, core-shell magnetic mesoporous silica (Fe 3 o 4 SiO 2 ) nanocomposites, as the focus of r...

Claims

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Application Information

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IPC IPC(8): C01G49/06C01B33/12B82Y30/00B82Y40/00A61K47/04A61K49/08A61P35/00
Inventor 陈立李晶邵丹
Owner JILIN UNIV
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