Magnetism/metal/fluorescence composite silicon dioxide nano particle and preparation method thereof

A technology of compounding silica and nanoparticles, which is applied in the field of nanomaterials, can solve problems such as the inability to eliminate the influence of magnetic particle absorption and reduce particle luminous efficiency, achieve good biocompatibility and chemical stability, improve sensitivity, and improve separation efficiency effect

Inactive Publication Date: 2008-02-20
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method of synthesizing magnetic fluorescent composite particles can control the distance between the magnetic nanoparticles and the luminophore, and eliminates the fluorescence quenching caused by energy transfer, but it cannot eliminate the influence of the magnetic particles on the absorption of the light emitted by the fluorophore, and still reduces the Luminous Efficiency of the Particles

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Synthesis of Embodiment 1 Ferrite Nanoparticles: Fe 3 o 4 Preparation of nanoparticles

[0021] Weigh 1g of FeCl 3 ·6H 2 O and 0.37 g FeCl 2 4H 2 O was dissolved in 20ml of water through nitrogen and deoxygenation to obtain a mixed solution. Take 130ml of water in a 250mL round-bottomed flask to pass through nitrogen to remove oxygen, add 12.5ml of concentrated ammonia water with a concentration of 25-28% by mass, and quickly pour the above-mentioned iron salt mixed solution into it under vigorous stirring. Under reaction 1h. After the reaction is completed, use a 0.1T permanent magnet to separate the black solid from the reaction solution, and wash the obtained solid with high-purity water for 3 to 5 times to obtain Fe with a particle size of 6 to 10 nm. 3 o 4 Nanoparticles.

Embodiment 2

[0022] Synthesis of Example 2 Ferrite Nanoparticles: CoFe 2 o 4 Preparation of nanoparticles

[0023] Weigh 1g of FeCl 3 ·6H 2 O and 0.38 g CoCl 2 4H 2 O was dissolved in 20ml of water through nitrogen and deoxygenation to obtain a mixed solution. Take 130ml of water in a 250mL round-bottomed flask to pass through nitrogen to remove oxygen, add 12.5ml of concentrated ammonia water with a concentration of 25-28% by mass, and quickly pour the above mixed salt solution into it under vigorous stirring. Reaction 1h. After the reaction is completed, use a 0.1T permanent magnet to separate the black solid from the reaction solution, and wash the obtained solid with high-purity water for 3 to 5 times to obtain CoFe with a particle size of 3 to 13 nm. 2 o 4 Nanoparticles. CoCl can be 2 Change to MnCl 2 or ZnCl 2 get the corresponding MnFe 2 o 4 or ZnFe 2 o 4 Nanoparticles.

[0024] The magnetic core is silica coated by an inorganic silicon source and an organic silicon...

Embodiment 3

[0025] Example 3 Coating the magnetic core with silica by inorganic silicon source and organic silicon source: Inorganic silicon source coating

[0026] Weigh 0.6g Na 2 SiO 3 (SiO 2 Content is 45%) be dissolved in 50ml water, be 9.6 with the pH adjustment solution of cationic resin, add 0.5g above-mentioned synthetic Fe wherein 3 o 4 Nanoparticles. At room temperature, the reaction was carried out in a 250 mL round bottom flask with a stirring speed of 150 rpm for 12 h. After the reaction is completed, use a 0.1T permanent magnet to separate the black solid from the reaction solution, and wash the obtained solid with high-purity water for 3 to 5 times to obtain a silica-coated Fe with a particle size of 7 to 12 nm. 3 o 4 Nanoparticles.

[0027] Will Fe 3 o 4 Nanoparticles replaced by CoFe 2 o 4 , MnFe 2 o 4 or ZnFe 2 o 4 Nanoparticles Corresponding inorganic silicon source silica-coated magnetic nanoparticles can be obtained.

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Abstract

The invention relates to magnetic / metal / fluorescence compound silicon dioxide nanometer particle and preparation method thereof, pertaining to nanometer material technical field. The nanometer particle is covered with an internal magnetic core, a metal layer and a lighting layer in sequence from interior to exterior; the internal magnetic core consists of organosilicon covering 6-1,000 ferrite nanometer particles; the metal layer is of a connection shell layer made of Ag or Au; the lighting layer is of SiO2 layer doped with organic lighting dye. The preparation method comprises steps of preparation of ferrite nanometer particles, laying silicon dioxide and metal layer to the internal magnetic core through inorganic silicon resource and organic silicon resource, secondary organic silicon layer coating and the coating of the layer doped with organic lighting dye. The nanometer particle of the invention has high lighting intensity and can dramatically improve detection sensitivity when being applied in biological marker, has rapid response in magnetic field, which improves separating rate; during preparation course, the control of magnetic matter content, diameter of particle and silicon dioxide shell layer through adjustment of reaction conditions.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, in particular to a magnetic / metal / fluorescent composite silicon dioxide nanoparticle and a preparation method thereof. Background technique [0002] Due to their unique magnetic properties (superparamagnetism) and luminescent properties, magnetic composite fluorescent nanoparticles have broad application prospects in biomedical fields such as bioseparation, immunodetection, and targeted imaging. Magnetic composite fluorescent nanoparticles generally embed magnetic nanoparticles and fluorescent quantum dots or organic luminescent dyes in an inorganic or polymer matrix to achieve the purpose of composite. Due to the advantages of good chemical and colloidal stability and good biocompatibility, silica is one of the most ideal materials for coating magnetic and fluorescent particles. However, in the magnetic composite fluorescent particles, due to the energy transfer between the magnetic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09C3/00C09C1/22B32B5/14B32B33/00C09K11/02H01F1/20
Inventor 杨文胜陆子阳董新义李军
Owner JILIN UNIV
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