Magnetic-acoustic-magnetic particle concentration imaging device and imaging method thereof

Abstract

The invention discloses a magnetic-acoustic-magnetic particle concentration imaging device and an imaging method thereof, and the device comprises a gradient magnetic field excitation unit which generates a gradient magnetic field and acts on an imaging body containing superparamagnetic nanoparticles; an magnetoacoustic signal acquisition and display unit which is used for acquiring magnetoacoustic signals and conditioning and displaying the acquired signals; a mechanical driving scanning unit which is used for driving the magnetoacoustic signal acquisition and display unit to perform annularscanning to receive an ultrasonic signal; an intelligent central control unit which is used for providing control signals for the gradient magnetic field excitation unit and the mechanical driving scanning unit as well as processing the acquired data; and a data storage and imaging unit which is used for further processing the acquired magnetoacoustic signals and carrying out image reconstructionon the magnetic particle concentration. A superparamagnetic nanoparticle concentration matrix is calculated by using the sound pressure information, and the ultrasonic information emitted by each point sound source is recorded through the annular scanning of an ultrasonic probe, so that the superparamagnetic nanoparticle concentrations at different positions are solved, and the whole space imagingis realized.

Description

technical field [0001] The invention belongs to the technical field of medical imaging technology, and in particular relates to a magnetoacoustic magnetic particle concentration imaging device and an imaging method, which are suitable for a superparamagnetic nanoparticle concentration imaging method based on electromagnetic pulse excitation and acoustic signal detection. Background technique [0002] In recent years, magnetic nanoparticles have been increasingly used in biomedicine, clinical diagnosis and treatment-related research, such as tumor magnetic hyperthermia, stem cell markers, gene delivery, drug-targeted therapy, disease diagnosis, etc., with good applications Prospects. [0003] Since B.Gleich and J.Weizenencker proposed the magnetic particle imaging method in 2005, this method has been widely studied at home and abroad. Magnetic particle imaging is to image the concentration of magnetic nanoparticles. It is a tracer-based imaging method, which has the advantag...

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Problems solved by technology

In 2014, Fang Dawei of Nanjing Normal University and others conducted research on magnetic induction nano-sensing technology, established a magnetic-induction magnetic-acoustic nano-sensing experimental system, conducted experimental research on the model of uniform distribution of magnetic nanoparticles, and detected the magnetic-acoustic signal , but no imaging research was carried out; in 2019, Zhang Shuai et al. proposed a time-reversal-based magnetodynamic ultrasonic imaging method, which achieved magnetic susceptibility imaging of nanoparticles, but did not clarify the relationship between the sound pressure and the concentration of magnetic nanoparticles

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