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Janus structure superparamagnetic nanoparticle and prepration method thereof

A superparamagnetic and nanoparticle technology, which is applied in the field of Janus structure superparamagnetic nanoparticles and its preparation, can solve the problems of cumbersome steps, limited application, small specific surface area, etc., and achieve wide biomedicine, narrow distribution range, monodisperse good sex effect

Active Publication Date: 2015-04-08
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The size of existing Janus particles is mostly distributed in the range of 1-100 microns, and the specific surface area is relatively small. Such a large size limits its application in biomedicine
In addition, the existing Janus particle preparation methods also have disadvantages such as cumbersome steps and the need for large-scale instrument assistance.

Method used

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  • Janus structure superparamagnetic nanoparticle and prepration method thereof
  • Janus structure superparamagnetic nanoparticle and prepration method thereof
  • Janus structure superparamagnetic nanoparticle and prepration method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0062] Embodiment one: preparation hydrophilicity--hydrophobic type Janus structure superparamagnetic nanoparticle PMMA / Fe 3 o 4 / PAA

[0063] 1. Preparation of hydrophobic chain polymer PMMA with carboxyl group by ARGET-ATRP reaction

[0064] Vacuumize the three-necked reaction flask equipped with an oil seal and ventilate nitrogen three times to ensure that the reaction system is anhydrous and oxygen-free. 6.72mg (0.05mmol) CuCl 2 , 86.65mg (0.5mmol) N,N,N',N',N″-pentamethyldiethylenetriamine (PMDETA), 99.06mg (0.5mmol) sodium ascorbate (SA) were dissolved in 2mL benzyl ether In, 5.006g (50mmol) methyl methacrylate (MMA) and 47.25mg (0.5mmol) chloroacetic acid (CA) were dissolved in 2mL benzyl ether. Under nitrogen protection and magnetic stirring, the CuCl 2 , PMDETA, SA, MMA and CA solutions were injected into the reaction system, reacted at 60-70°C for 8 hours, cooled to room temperature after the reaction, and obtained polymethyl methacrylate (PMMA) colloid. Dissolv...

Embodiment 2

[0076] Example two: Preparation of pH-sensitive--temperature-sensitive Janus structure superparamagnetic nanoparticles PMAA / Fe 3 o 4 / PNIPAM

[0077] 1, with reference to the method shown in embodiment one, prepare superparamagnetic composite microsphere PMMA / Fe 3 o 4 .

[0078] 2. Preparation of temperature-sensitive polymer brush grafted superparamagnetic composite microspheres PMMA / Fe by ARGET-ATRP reaction 3 o 4 / PNIPAM

[0079] Vacuumize the three-necked reaction flask equipped with an oil seal and ventilate nitrogen three times to ensure that the reaction system is anhydrous and oxygen-free. 100mg superparamagnetic composite microspheres PMMA / Fe 3 o 4 After being dispersed in 20mL of ethanol, inject into the reaction system; after dissolving 300mg of chloroacetic acid (CA) in 5mL of ethanol, inject into the reaction system. Under the condition of avoiding light and nitrogen protection, the reaction was carried out under magnetic stirring at 60-70° C. for 24 hour...

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Abstract

The invention discloses a Janus structure superparamagnetic nanoparticle and a prepration method thereof. The Janus structure superparamagnetic nanoparticle adopts a superparamagnetic nanoparticle as a core; two sides of the surface of the superparamagnetic nanoparticle are respectively grafted with polymer brushes with different properties; and the polymer brushes include hydrophilic-hydrophobic polymer brushes, pH sensitive-temperature sensitive polymer brushes and the like. The Janus structure superparamagnetic nanoparticle disclosed by the invention has the advantages of small particle size, narrow distribution range, functionalized surface and the like.

Description

technical field [0001] The invention relates to a superparamagnetic nanoparticle and a preparation method thereof, in particular to a Janus structure superparamagnetic nanoparticle and a preparation method thereof. Background technique [0002] Janus is a two-faced god in ancient Roman mythology, with a left-right asymmetrical face. In 1991, Nobel Prize winner De Gennes named the particle with left-right asymmetric structure as Janus particle (Reviews of Modern Physics, 1992, 64, 645-648). Due to its heterogeneous structure, Janus particles provide a rich model and theoretical research platform for the construction and controllable assembly of nanomaterials. Its applications in biomedical fields such as magnetic hyperthermia, asymmetric catalysis, and single-sided drug delivery There are also reports. [0003] At present, the common structure types of Janus particles include: composite microspheres composed of two kinds of inorganic microspheres with different properties, ...

Claims

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Application Information

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IPC IPC(8): C08F265/04C08F220/06C08F220/54C08F120/14C08J9/28C08F8/42C08F8/24C08J3/00
Inventor 解丽芹冯志伟井长勤陈红丽赵亮王勉陈淑丽
Owner XINXIANG MEDICAL UNIV
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