Retinoic acid release control nanomicrosphere and its preparation method

A technology of nano-microspheres and retinoic acid, which is applied in the direction of active ingredients of anhydride/acid/halide, bulk delivery, skin diseases, etc., and can solve the problem that patients who are unstable in the presence of light, cannot take it orally, and have low effective drug utilization And other issues

Inactive Publication Date: 2009-02-18
于美丽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, RA is a weak organic acid with conjugated double bonds, which is unstable when exposed to light in the air, and the oral dosage form is easily oxidized.
At present, RA only has oral preparations, which are slowly absorbed through the gastrointestinal tract, and the effective utilization of the drug is low. The treatment of leukemia and tumor patients is subject to certain restrictions.
Due to the short half-life of RA drugs, it needs to be taken three times a day. Patients who take the drug on time and in the right amount will experience varying degrees of digestive tract discomfort and dizziness and vomiting symptoms. Patients who cannot take it orally should not take it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Polylactic acid (PLA), 13%,

[0024] Retinoic Acid (RA), 35%,

[0025] Gelatin in water, 52%.

Embodiment 2

[0027] Polylactic acid (PLA), 15%,

[0028] Retinoic Acid (RA), 35%,

[0029] Gelatin in water, 50%.

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Abstract

The invention relates to a medicinal control release nanometer and method for making same, in particular a retinoic acid release control nanomicrosphere and its preparation method, the constituents of the composition are polylactic acid (PLA), vitamin A acid (RA) and gelatin aqueous solution.

Description

technical field [0001] The invention relates to a drug controlled-release nanometer and a preparation method thereof, in particular to a retinoic acid controlled-release nanometer microsphere and a preparation method thereof. Background technique: [0002] Retinoic acid (RA-retinoic acid,) is a natural oxidative metabolite of vitamin A. It has been used as a dermatological drug for a long time to resist abnormal skin keratosis. In recent years, it has been clinically used in solid cancers, such as liver cancer, gastric cancer, breast cancer It can be used as synergistic drug in the chemotherapy of patients with cancer, etc., and has achieved good curative effect. In 1987, Wang Zhenyi and others used RA to treat acute promyelocytic leukemia (APL-acutepromyelocytic leukemia) successfully. It has been confirmed that RA has a strong effect on the induction and differentiation of APL. In addition, RA can also inhibit leukocyte strains, prevent certain cells from becoming malign...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K9/16A61P17/00A61P35/00
Inventor 于美丽方淑昌
Owner 于美丽
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