Repetitive transcranial magnetic stimulation method capable of carrying out multi-stimulation-target focusing

Abstract

The invention discloses a repetitive transcranial magnetic stimulation method capable of carrying out multi-stimulation-target focusing. The repetitive transcranial magnetic stimulation method specifically comprises the following steps of: 1) obtaining multiple-modality brain magnetic resonance image data of a subject; 2) determining a target deep effect brain area; 3) determining a plurality of superficial cortex stimulation brain areas connected with the effect brain area; 4) measuring individualized motor evoked potential, determining an individualized motor threshold, and setting the stimulation intensity of repetitive transcranial magnetic stimulation capable of carrying out the multi-stimulation-target focusing; 5) confirming a stimulation total quantity, and guaranteeing that each stimulation target equally divides the stimulation total quantity; and 6) carrying out individualized magnetic resonance image data navigation based repetitive transcranial magnetic stimulation capableof carrying out the multi-stimulation-target focusing, and independently stimulating selected stimulation targets in sequence. By use of the stimulation method, through connection between a pluralityof stimulation targets and the deep effect brain area, the neural activity of the deep effect brain area is regulated and controlled through targeted focusing to achieve a treatment effect.

Description

technical field [0001] The invention belongs to the technical field of clinical and scientific research transcranial magnetic stimulation, and in particular relates to a repetitive transcranial magnetic stimulation method focusing on multiple stimulation targets. Background technique [0002] Transcranial Magnetic Stimulation (TMS) technology was first approved in the United States for the clinical treatment of depression. It is a non-invasive neuromodulation technology that generates rapidly changing currents through its capacitors and transmits them to the coil, so that Changing strong magnetic field to interfere with brain function. Repetitive Transcranial Magnetic Stimulation (rTMS) stimulates a target point continuously to produce a cumulative effect, which can effectively regulate brain activity. rTMS mostly uses an "8"-shaped coil. When the coil is placed on the surface of the skull, the magnetic field passes through the scalp and skull and focuses on the cerebral co...

AI Technical Summary

Problems solved by technology

[0005] 1) There are functional connections between any deep brain region and multiple superficial cortices, and this type of research is only from a single cortical target to a deep brain region;

[0006] 2) Stimulating a single target for a long time may cause discomfort such as local pain (Di Iorio&Rossini, 2017), headache (Loo, McFarquhar, & Mitchell, 2008)

[0007] 3) Overstimulation of a single target

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