Application of rutin medicines to preparing medicines for preventing or treating medicine-induced cardiac toxicity
A cardiotoxicity and cardiotoxicity technology, applied in the directions of drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve the problem of prevention or treatment. There are no reports or inspirations, no research reports on the cardiotoxicity of rutin drugs, and different pathogenic factors, etc. question
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
experiment example
[0054] The combination of rutin and anthracycline in different doses was prepared according to the ratio in Table 1 below.
[0055] For the liquid combination of rutins in Examples 1 to 32, rutins and anthracyclines of corresponding concentrations can be prepared into the same solution, and then used directly when administered; they can also be made into corresponding Concentration solutions are then mixed and used directly during administration; they can also be administered after mixing during use, or administered to subjects separately, and the sequence of their administration is not limited.
[0056] For the combination of rutin drugs administered through the gastrointestinal tract in Examples 1-32, the corresponding quality of rutin drugs and anthracycline drugs can be directly mixed and taken at the same time; they can also be made into unit preparations respectively , administered to the subject at the same time, or sequentially, but the order of use between them is not...
experiment example 1
[0068] Experimental example 1 in vitro test
[0069] 1.1.1 The effect of different proportions of rutin on the inhibitory rate of H9c2 cells (MTT method)
[0070] experiment method:
[0071]H9c2 cardiomyocytes were seeded in 96-well culture plates. When the cells grew to about 80% of the culture well area, different treatments were carried out according to the needs of the experiment: (1) 10, 30, 50, 70 and 100 μmol / L different concentrations of Rutin (Rutin) was pretreated for 1 hour, discarded, washed twice with PBS, and cultured with 5 μmol / L pirarubicin for 24 hours; L-pirarubicin was cultured for 24 hours; 8 replicate wells were set up for each treatment factor. After terminating the culture, add 10 μL MTT to each well, shake gently, and incubate at 37°C. Then measure cell inhibition rate=(1-OD value of experimental group / OD value of control group)×100%. The measurement results are shown in Table 2 and figure 1 .
[0072] Data statistics The SPSS 17.0 software was u...
experiment example 2
[0087] Experimental example 2 in vivo test
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com