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Long-acting compound sulfamonomethoxine injection and preparation method thereof

A technology of sulfamonomethoxine and compound sulfamethoxazole, which is applied in the field of long-acting compound sulfamethoxazole injection and its preparation, and achieves the effects of convenient administration, reduction of administration times, and avoidance of side effects

Inactive Publication Date: 2013-01-23
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, the treatment of livestock and poultry diseases generally requires medication 2 to 3 times a day. Continuous use for 3 to 5 days, in this way, after many times of medicating and catching sick livestock and poultry, it will cause adverse stimulation to livestock and poultry, promote the occurrence of many stress diseases of livestock and poultry, and then lead to the decline of disease resistance of livestock and poultry, causing many livestock and poultry The occurrence and spread of poultry diseases
In addition, taking multiple medications every day will cause the drug concentration in the blood to fluctuate greatly, leading to the phenomenon of "peak valley". , when the drug concentration drops to the trough, it is far below the required concentration, and it is difficult to play a role

Method used

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  • Long-acting compound sulfamonomethoxine injection and preparation method thereof
  • Long-acting compound sulfamonomethoxine injection and preparation method thereof
  • Long-acting compound sulfamonomethoxine injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0016] A long-acting compound sulfamethoxine injection, which is mainly made of the following raw materials in parts by weight: sulfamethoxine (SMM) 8%, trimethoprim (TMP) 1.6%, propylene glycol 40%, ethanol 8% %, ethanolamine 1%, benzyl alcohol 1%, polyvinylpyrrolidone (PVP) 1%, the rest is water for injection; the pH value of the injection is 7.0.

[0017] The preparation method of the long-acting compound sulfamethoxine injection comprises the following steps: mixing benzyl alcohol with part of the water for injection, then adding polyvinylpyrrolidone and stirring to dissolve, then adding propylene glycol and ethanol, at 75°C Heat for 7 minutes, then add sulfamethoxine and trimethoprim, stir well, add ethanolamine and continue heating at 95°C for 30 minutes, add the remaining water for injection and mix well, adjust the pH value to 7.0 with a small amount of ethanolamine, filter After potting and sterilizing, the finished product is obtained.

Embodiment 2

[0019] A long-acting compound sulfamethoxine injection, which is mainly made of the following raw materials in parts by weight: sulfamethoxine (SMM) 12%, trimethoprim (TMP) 2.4%, propylene glycol 55%, ethanol 12% %, ethanolamine 3%, benzyl alcohol 4%, polyvinylpyrrolidone (PVP) 4%, the rest is water for injection; the pH value of the injection is 9.5.

[0020] The preparation method of the long-acting compound sulfamethoxine injection comprises the following steps: mixing benzyl alcohol with part of the water for injection, then adding polyvinylpyrrolidone and stirring to dissolve, then adding propylene glycol and ethanol, at 85°C Heat for 7 minutes, then add sulfamethoxine and trimethoprim, stir well, add ethanolamine and continue heating at 100°C for 30 minutes, add the remaining water for injection and mix well, adjust the pH value to 9.5 with a small amount of ethanolamine, filter After potting and sterilizing, the finished product is obtained.

Embodiment 3

[0022] A long-acting compound sulfamethoxine injection, which is mainly made of the following raw materials in parts by weight: sulfamethoxine (SMM) 10%, trimethoprim (TMP) 2%, propylene glycol 50%, ethanol 10% %, ethanolamine 2%, benzyl alcohol 3%, polyvinylpyrrolidone (PVP) 3.5%, and the balance is water for injection; the pH value of the injection is 8.5.

[0023] The preparation method of the long-acting compound sulfamethoxine injection comprises the following steps: mixing benzyl alcohol with part of the water for injection, then adding polyvinylpyrrolidone and stirring to dissolve, then adding propylene glycol and ethanol, at 82°C Heat for 9 minutes, then add sulfamethoxine and trimethoprim, stir well, add ethanolamine and continue heating at 97°C for 30 minutes, add the remaining water for injection and mix well, adjust the pH value to 8.5 with a small amount of ethanolamine, filter After potting and sterilizing, the finished product is obtained.

[0024] Concentrat...

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Abstract

The invention belongs to the technical field of veterinary medicament preparations, and particularly discloses a long-acting compound sulfamonomethoxine injection and a preparation method thereof. The long-acting compound sulfamonomethoxine injection is prepared from the following raw materials in percentage by weight: 8-12 percent of sulfamonomethoxine (SMM), 1-3 percent of trimethoprim (TMP), 40-55 percent of propylene glycol, 8-12 percent of ethanol, 1-3 percent of cholamine, 1-4 percent of benzyl alcohol, 1-4 percent of polyvinylpyrrolidone (PVP) and the balance of water for injection. In the long-acting compound sulfamonomethoxine injection, polyvinylpyrrolidone serving as a sustained-release material is added and is uniformly dispersed into a treatment medicament, so that the medicament can be released slowly after entering an animal body, the half-life period of the medicament is prolonged, effective blood concentration is maintained for a long time, side effects caused by 'peak valley' fluctuation of the blood concentration are reduced or avoided, and the aims of high efficiency, long-acting property and stability are fulfilled.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a long-acting compound sulfamethoxine injection and a preparation method thereof. Background technique [0002] In recent years, my country's breeding industry has shown a rapid development trend, especially in some economically developed areas and pastoral areas, more and more livestock and poultry varieties have been introduced, and disease problems have followed one after another, and outbreaks have continued in various regions and farms For livestock and poultry diseases, due to the uneven technical strength of various farms and limited diagnostic testing equipment, many clinical veterinarians are confused about medication, and abuse and non-targeted medication problems have become a common phenomenon. This further promotes the continuous generation of bacterial drug-resistant strains, making the prevention and treatment of livestock and poultry diseases ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/08A61P31/04A61P33/02A61K31/505
Inventor 赖登明张遂平董战杰郭菊杨慧敏杨果
Owner 河南亚卫动物药业有限公司
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