Medicine composition containing oral glucocorticoid and oral bronchodilator

A technology of bronchodilators and glucocorticoids, which is applied in the field of pharmaceutical preparations, can solve problems such as narrow therapeutic windows, and achieve the effect of increasing curative effect and low price

Inactive Publication Date: 2010-08-11
莫始平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, theophylline has a narrow therapeutic window, and the therapeutic dose is close to the toxic dose.

Method used

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  • Medicine composition containing oral glucocorticoid and oral bronchodilator
  • Medicine composition containing oral glucocorticoid and oral bronchodilator
  • Medicine composition containing oral glucocorticoid and oral bronchodilator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 compound prednisone formoterol sheet

[0021] The formula of 1000 tablets of compound prednisone formoterol is:

[0022] Prednisone 1.25g

[0023] Formoterol 0.08g

[0024] Starch 100g

[0025] Microcrystalline Cellulose 50g

[0026] Sodium carboxymethyl starch 20g

[0027] Low-substituted hydroxypropyl cellulose 20g

[0028] Proper amount of povidone ethanol solution

[0029] Magnesium Stearate 1%

[0030] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 1.25g of prednisone and 0.08g of formoterol and mix them uniformly according to the method of equal increase, and add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the prescription amount, and Mix uniformly by incremental method, make soft material with 5% povidone ethanol solution, granulate with 20 mesh sieve, dry at 40°C for about 2 hours, granula...

Embodiment 2

[0031] The composition of embodiment 2 prednisolone and formoterol

[0032] The composition of this example contains 5 mg of prednisolone and 40 μg of formoterol.

Embodiment 3

[0033] The composition of embodiment 3 methylprednisolone and formoterol

[0034] The composition of this example contains 1.25 mg of methylprednisolone and 60 μg of formoterol.

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Abstract

The invention discloses a medicine composition mainly containing oral glucocorticoid and an oral bronchodilator, as well as application thereof in preparing medicines for treating chronic obstructive pulmonary diseases (COPD) and bronchial asthma, which belongs to the technical field of medicine preparations. The oral glucocorticoid contained in the medicine composition is prednisone, prednisolone or methylprednisolone, and the oral bronchodilator is formoterol, clenbuterol or euphylline. The curative effect of the composition for treating the COPD or the bronchial asthma is better than that of separately using the two composition ingredients one after another, and the composition has the characteristics of synergistic action and low cost. Thus, the combination preparation of the oral glucocorticoid and the oral bronchodilator is of great significance to the treatment and the prevention of the COPD and the bronchial asthma of patients of lower income groups in wide rural and urban areas in China.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition mainly containing an oral glucocorticoid and an oral bronchodilator, and the preparation of the composition for the treatment of chronic obstructive pulmonary disease (COPD) and bronchial asthma. use in . Background technique [0002] Chronic obstructive pulmonary disease (COPD) and bronchial asthma are the two most common and frequently occurring diseases of the respiratory system, among which COPD is a preventable and treatable disease characterized by airflow limitation, which is not completely reversible , which develops progressively and is associated with an abnormal inflammatory response of the lungs to noxious gases or particles. At present, it is generally believed that the mechanism of its occurrence is: chronic inflammation of the central airway, peripheral airway, lung parenchyma and pulmonary blood vessels causes path...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/522A61K31/167A61K31/137A61P11/00A61P11/06A61P11/08
Inventor 冯玉麟
Owner 莫始平
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