Cefuroxime sodium pharmaceutical composition and preparation method thereof
A technology of cefuroxime sodium and its composition, which is applied in the field of pharmaceutical preparations and preparations, can solve the problems of large dosage of metronidazole, strong toxic and side effects of metronidazole, etc., and achieve the effect of simple preparation process and guaranteed stability
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Embodiment 1
[0033] Embodiment 1, cefuroxime sodium composition powder for injection, in 1000 pieces
[0034] Prescription (specification: 0.75g):
[0035]
[0036] Preparation Process:
[0037] Add the prescribed amount of metronidazole lipid microspheres (calculated as metronidazole) directly to an appropriate amount of water for injection; stir and dissolve, then add a pH regulator to adjust the pH of the solution so that it is in the range of 6.5-6.8; 0.45μm and 0.22μm filter membranes are used for sterilization cycle filtration for 30 minutes; after the sampling inspection meets the requirements, the solution is divided into stainless steel trays, put into a freeze-drying box, and freeze-dried to obtain sterile freeze-dried metronidazole powder, pulverized and sieved; mix the pulverized and sieved freeze-dried metronidazole powder and cefuroxime sodium sterile powder, and after sampling and testing meet the requirements, subpackage according to the marked amount to obtain the requ...
Embodiment 2
[0038] Embodiment two, cefuroxime sodium composition powder injection for injection, in 1000 pieces
[0039] Prescription (specification: 1.5g):
[0040]
[0041] Preparation Process:
[0042] Add the prescribed amount of metronidazole lipid microspheres (calculated as metronidazole) directly to an appropriate amount of water for injection; stir and dissolve, then add a pH regulator to adjust the pH of the solution so that it is in the range of 6.5-6.8; 0.45μm and 0.22μm filter membranes are used for sterilization cycle filtration for 30 minutes; after the sampling inspection meets the requirements, the solution is divided into stainless steel trays, put into a freeze-drying box, and freeze-dried to obtain sterile freeze-dried metronidazole powder, pulverized and sieved; mix the pulverized and sieved freeze-dried metronidazole powder and cefuroxime sodium sterile powder, and after sampling and testing meet the requirements, subpackage according to the marked amount to obta...
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