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Calcipotriol betamethasone self-microemulsion preparation with excellent performance

A technology of calcipotriol and betamethasone, applied in medical preparations containing non-active ingredients, medical preparations containing active ingredients, emulsion delivery, etc., can solve problems such as good stability of difficult active compounds, and achieve reduction Individual differences in medication, improvement of clinical adverse reactions, and the effect of increasing medication compliance

Inactive Publication Date: 2017-01-04
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult to combine the two active ingredients in a single formulation while maintaining good stability of the active compound when water is present in the formulation

Method used

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  • Calcipotriol betamethasone self-microemulsion preparation with excellent performance
  • Calcipotriol betamethasone self-microemulsion preparation with excellent performance
  • Calcipotriol betamethasone self-microemulsion preparation with excellent performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The composition is as follows:

[0041]

[0042] Description: The degree of polymerization of ethylene glycol groups in the molecular structure of caprylic capric acid macrogol glyceride is 2, and the proportion of fatty acids (distribution) in the molecular structure is: the proportion of caprylic acid is 95.4%, the proportion of capric acid is 3.0%, and the proportion of dodecanoic acid The sum of its higher fatty acids and lower fatty acids than caprylic acid is 1.6%.

Embodiment 2

[0044] The composition is as follows:

[0045]

[0046] Explanation: The degree of polymerization of ethylene glycol group in the molecular structure of caprylic capric acid macrogol glyceride is 4, and the proportion of fatty acids (distribution) in the molecular structure is: the proportion of caprylic acid is 91.6%, the proportion of capric acid is 6.6%, and the proportion of dodecanoic acid The sum of its higher fatty acids and lower fatty acids than caprylic acid is 1.8%.

Embodiment 3

[0048] The composition is as follows:

[0049]

[0050] Explanation: The degree of polymerization of ethylene glycol group in the molecular structure of caprylic capric acid macrogol glyceride is 4, and the proportion of fatty acids (distribution) in the molecular structure is: the proportion of caprylic acid is 91.6%, the proportion of capric acid is 6.6%, and the proportion of dodecanoic acid The sum of its higher fatty acids and lower fatty acids than caprylic acid is 1.8%.

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Abstract

The invention discloses a calcipotriol betamethasone self-microemulsion preparation with excellent performance, and the self-micromulsion preparation contains main drugs (namely the derivative or analogue of vitamin D (such as calcipotriol) and betamethasone), glycerides, C8-10 mono-and di-, propylene oxygen-15-S-stearyl ether, oleamide, oil phase and co-emulsifier. In the molecular structure of the glycerides, C8-10 mono-and di-, the degree of polymerization of the ethylene glycol is 2-4, and the composition ratio of the aliphatic acid in the molecular structure of the glycerides, C8-10 mono-and di- is that the percentage of octanoic acid is no less than 88%, the percentage of decanoic acid is no more than 10%, and the total proportions of lauric acid, aliphatic acid which are more advanced than lauric acid and aliphatic acid which are more lower than octanoic acid are no less than 2%. The stability, particularly the clinical effect of the composition, is improved.

Description

technical field [0001] The invention relates to a calcipotriol-betamethasone self-microemulsion preparation with excellent performance. More specifically, a calcipotriol-betamethasone self-microemulsion preparation with excellent stability and clinical effect. Background technique [0002] During the treatment of psoriasis, combination therapy comprising two or more different pharmacologically active compounds is often required. Reported patient noncompliance with treatment orders for chronic diseases such as psoriasis presents a serious challenge to healthcare workers. As a compound preparation for the treatment of psoriasis, on the one hand, the form of external application of this composition makes the administration of calcipotriol-betamethasone ointment more convenient, and the compliance between doctors and patients is better. Calcipotriol, on the other hand, is a vitamin D3 analogue, and betamethasone dipropionate, a glucocorticoid, is more effective when used in co...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/593A61K47/34A61K47/18A61P17/06A61P17/00A61P17/10A61P17/08A61K31/573
CPCA61K9/1075A61K31/573A61K31/593A61K47/14A61K47/18A61K2300/00
Inventor 王学政王晶吕鹤涛
Owner JIANGSU SEMPOLL PHARMA
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