The present invention discloses a method for mechanically assisted allylic selective oxidation, which relates to the technical field of selective oxidation of organic compounds. The method comprises the following steps: mixing a
metal-ligand complex, a base, 2,2,6,6-tetramethylpiperidine
oxide and its derivatives, a
solvent and a reaction substrate, and then carrying out a reaction under the action of mechanical external force to achieve allylic selective oxidation and obtain an allylic selectively oxidized product. The present invention adopts an S-Phos / Ag
catalytic oxidation system to achieve the construction of a fully
hydrocarbon backbone regio- and stereoselective oxidation reaction without the participation of a
reducing agent, without using expensive
palladium as a catalyst, and avoiding the generation of a large amount of
chemical waste. The present invention selects ball milling
mechanochemistry to replace the traditional
solution system, avoiding the use of a large amount of organic solvents, with less waste
discharge,
resource conservation, environmental friendliness, high atom
utilization rate, and having the characteristics of simple operation, short reaction time and high efficiency, which is beneficial to industrial-scale preparation.