Toothpaste for preventing and treating oral ulcer as well as preparation method and application thereof

A technology for oral ulcers and toothpaste is applied in the field of toothpaste that can prevent and treat oral ulcers and the preparation field thereof, and can solve the problems of limited curative effect of oral ulcers, increased maintenance costs, complex whey protein treatment process, etc.

Active Publication Date: 2018-08-10
江苏蒲地蓝日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN106619179A discloses a toothpaste for preventing and treating oral ulcers, which prevents and treats oral ulcers by adding whey protein, lysozyme and chitosan, but its main active ingredients lysozyme and whey protein belong to protein substances, It is easy to denature, and requires strict storage conditions during production, transportation, sales, and use. The temperature should not be too high or too low, which greatly increases maintenance costs
Moreover, the processing technology of whey protein is very complicated, and the price is relatively expensive, which greatly increases the economic burden of patients.
[0005] Many Chinese herbal medicines have anti-inflammatory and antibacterial effects, and the Chinese medicine extracts are mild, safe and have

Method used

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  • Toothpaste for preventing and treating oral ulcer as well as preparation method and application thereof
  • Toothpaste for preventing and treating oral ulcer as well as preparation method and application thereof
  • Toothpaste for preventing and treating oral ulcer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1 Oral ulcer toothpaste and its preparation

[0068] formula:

[0069]

[0070]

[0071] Preparation:

[0072] Pudilan three-flavor medicinal extract: 500g of dandelion, 125g of kudiding, 188g of Radix Isatidis, add water to extract twice, add 10 times the amount of water for the first time, soak for 30 minutes, extract at 55°C for 60 minutes, add 8 times the amount of water for the second time, 55°C Extract for 60 minutes, filter, combine the filtrates, concentrate to a relative density of 1.1-1.2, add ethanol to make the alcohol content reach 65%, let it stand for 48 hours, concentrate the supernatant to a relative density of 1.1-1.2, add ethanol to make the alcohol content reach 80% %, let it stand for 24h, and the supernatant was concentrated to a relative density of 1.28-1.32 extract.

[0073] Gallnut extract: Gallnuts are knocked open to remove impurities, extracted twice with water, add 10 times the amount of water for the first time, extract a...

Embodiment 2

[0086] Embodiment 2 Oral ulcer toothpaste and its preparation

[0087] formula:

[0088] Scutellaria Root Extract

0.10％

xanthan gum

0.4％

Pudilan three herbs extract

0.10％

Cellulose gum

0.1％

Gallnut Extract

0.45％

polyethylene glycol-8

3.5％

Campanula Extract

0.10％

Glycerin

10.5％

Ophiopogon japonicus extract

0.08％

Sorbitol

47.5％

Tranexamic acid

0.02％

thickening hydrated silica

7％

Allantoin

0.2％

Comprehensive hydrated silica

12％

citric acid

0.03％

Attrition Type Hydrated Silica

4％

Sodium citrate

0.05％

Sodium Lauryl Sulfate

2.5％

sodium saccharin

0.14％

Cocamidopropyl Betaine

0.3％

Propylparaben Sodium

0.05％

spearmint oil

1.1％

sodium butylparaben

0.02％

purified water

margin

[0089] Preparation:

[0090] Pudilan three-flavor medicinal extract: dandelion ...

Embodiment 3

[0104] Embodiment 3 oral ulcer toothpaste and preparation thereof

[0105] formula:

[0106] Scutellaria Root Extract

0.20％

xanthan gum

0.6％

Pudilan three herbs extract

0.30％

Cellulose gum

0.3％

Gallnut Extract

0.35％

polyethylene glycol-8

2.5％

Campanula Extract

0.15％

Glycerin

11％

Ophiopogon japonicus extract

0.15％

Sorbitol

50％

Tranexamic acid

0.08％

thickening hydrated silica

6％

Allantoin

0.05％

Comprehensive hydrated silica

10％

citric acid

0.05％

Attrition Type Hydrated Silica

4.5％

Sodium citrate

0.04％

Sodium Lauryl Sulfate

2.0％

sodium saccharin

0.18％

Cocamidopropyl Betaine

0.2％

Propylparaben Sodium

0.02％

spearmint oil

1.2％

sodium butylparaben

0.03％

purified water

margin

[0107] Preparation:

[0108] Pudilan three-flavor medicinal extract: dande...

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PUM

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Abstract

The invention belongs to the field of articles of everyday use, and particularly provides toothpaste for preventing and treating oral ulcer as well as a preparation method and application thereof. Thetoothpaste is prepared from an extract of three drugs of herba taraxaci, herba corydalis bungeanae and radix isatidis, a galla chinensis extract, a radix scutellariae extract, a herba clinopodii chinensis extract, a radix ophiopogonis extract, tranexamic acid, allantoin, an accessory and purified water. The toothpaste for preventing and treating the oral ulcer, which is provided by the invention,can be used for effectively treating and/or preventing a recurrent aphthous ulcer and oral lichen planus, and moreover, has favorable stability and foamability.

Description

technical field [0001] The invention relates to a toothpaste and its preparation method and application, in particular to a toothpaste capable of preventing and treating oral ulcers, its preparation method and application. Background technique [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. There are many types of oral ulcers, such as recurrent aphthous stomatitis, Behcet's syndrome, traumatic ulcers, cancerous ulcers, herpes simplex, radiation stomatitis, and tuberculous ulcers. Among them, recurrent aphthous stomatitis has the highest incidence rate, and the common cold, indigestion, mental stress, depression and other conditions can occasionally cause the occurrence of the disease. When it occurs, the pain is se...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/98A61K8/9794A61Q11/00A61K36/8968A61P1/02A61K31/195A61K31/4166
CPCA61K8/987A61K31/195A61K31/4166A61K36/195A61K36/288A61K36/315A61K36/53A61K36/539A61K36/86A61K36/8968A61Q11/00A61K35/63A61K8/9789A61K8/9794A61P1/02A61K2300/00
Inventor 曹龙祥田刚董自波夏立武杨志伟蔡虎
Owner 江苏蒲地蓝日化有限公司
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