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Biological medical membrane and method of preparing the same

A biotype and drug film technology is applied in the field of tablet dosage form and drug film for the treatment of oral diseases to achieve the effects of protecting cell damage, enhancing immunity and protecting wound surfaces.

Inactive Publication Date: 2011-04-13
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no reports and products about regulating immunity, supplementing vitamins and trace elements, and improving nutrient metabolism.

Method used

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  • Biological medical membrane and method of preparing the same
  • Biological medical membrane and method of preparing the same
  • Biological medical membrane and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Raw materials used: 5g of brewer's yeast, 10g of polyvinyl alcohol, 2g of glycerin, 1g of peppermint oil, and 100ml of distilled water.

[0045] (1) Preparation of film-forming material slurry: soak 10g of polyvinyl alcohol in 50ml of distilled water overnight to make it fully absorb water and swell, then heat and dissolve on a water bath and filter to obtain a uniform slurry without lumps and particles.

[0046] (2) Grind inactivated brewer's yeast, glycerin, peppermint oil and 20ml of distilled water, and slowly suspend them in the slurry prepared above while stirring, add the remaining amount of distilled water and stir evenly, and place the prepared drug glue in about In a water bath at 60°C, keep warm for 30 minutes to make the bubbles expand and rise to the liquid level to eliminate them.

[0047] (3) Membrane making, drying, and stripping; pour the membrane slurry added with the liquid medicine on a smooth, flat plate (such as flat glass) coated with a release ag...

Embodiment 2

[0050] Raw materials used: 10g of brewer's yeast, 10g of sodium carboxymethylcellulose, 2g of glycerin, 1g of peppermint oil, and 100ml of distilled water.

[0051] (1) Preparation of film-forming material slurry: Soak 10 g of sodium carboxymethyl cellulose and 50 ml of distilled water overnight to make it fully absorb water and swell, then heat to dissolve on a water bath and filter to obtain a uniform slurry without lumps and particles.

[0052] (2) Grind the inactivated brewer's yeast, glycerin, peppermint oil and 20ml distilled water, and slowly suspend them in the slurry prepared above while stirring, add the remaining distilled water and stir well, put the prepared drug glue in about In a 60°C water bath, keep warm for 15 to 30 minutes, so that the bubbles are heated and expanded to the liquid level to eliminate them.

[0053] (3) Membrane making, drying, and stripping; pour the membrane slurry added with the liquid medicine on a smooth, flat plate (such as flat glass) c...

Embodiment 3

[0056] Raw materials used: 5g of brewer's yeast, 5g of polyvinyl alcohol, 5g of sodium carboxymethylcellulose, 2g of glycerin, 1g of peppermint oil, and 100ml of distilled water.

[0057] (1) Preparation of film-forming material slurry: polyvinyl alcohol, sodium carboxymethyl cellulose and 50ml of distilled water are soaked overnight to make it fully absorb water and swell, then heat and dissolve on a water bath and filter to obtain uniform no lumps and particles of the slurry.

[0058] (2) Grind the inactivated brewer's yeast, glycerin, peppermint oil and 20ml of distilled water, and slowly suspend it in the slurry prepared above while stirring, add the remaining distilled water, and place the prepared drug glue in a water bath at about 60°C In the middle, keep warm for 15 to 30 minutes, the bubbles can be heated and expanded to the liquid level and eliminated.

[0059] (3) Membrane making, drying, and stripping; pour the membrane slurry added with the liquid medicine on a s...

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Abstract

The invention discloses a biological type drug membrane and a preparation method thereof. The main components of the biological type drug membrane are leaven and additives including film-forming material, plasticizer, aromatic and so on. The making process flow of the drug membrane is as follows: firstly the slurry of the film-forming material is prepared; inactivated leaven and the additives areadded and evenly mixed, and then the processes of deaeration, coating, drying, deciduation and packing are carried out. Compared with the prior art, by adopting the leaven as the main component, the drug membrane not only plays a role of protecting a wound surface but also improves the nutrient metabolism of oral mucosa, protects various cell injuries and enhances body immunity. In addition, the drug membrane has the characteristics of small volume and light weight and is also more convenient for being easy to be packed, stored, transported, carried over and used. The biotype-drug membrane ismainly used for treating various congestion, erosion and ulcerous lesion. And the biological type drug membrane has good effect on treating recurring Aphthous ulcer and oral lichen planus (congestiveand erosive type).

Description

technical field [0001] The invention belongs to the field of medical preparations, is a medicine film for treating oral diseases, and relates to a tablet dosage form composed of yeast, chitosan, vinyl polymer materials, polymerized alkyl cellulose, aromatic agents and the like. Background technique [0002] With the development of science and technology, new film-forming materials are constantly emerging, and the application of drug film preparations is more extensive. Mucosal trauma, burn or inflammation surface covering, ENT, etc., for local or systemic treatment. The oral mucosa is thinner and easier for drugs to penetrate than the skin. There are a large number of capillaries in the submucosa to the internal jugular vein, which directly reach the heart without passing through the liver. Therefore, administration of the oral mucosa can avoid the first-pass effect of the liver, accelerate and / or prolong the action of the drug, improve bioavailability, and reduce drug admi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/064A61K9/70A61K47/32A61K47/36A61K47/38A61K47/42A61P1/02A61P17/02A61K47/10A61K47/44
Inventor 刘为国韩立赤牛莹朱英飞
Owner DALIAN UNIV
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