Pharmaceutical composition for treating oral lichen planus, and preparation method and application thereof

A technology for oral lichen planus and composition, which is applied in the field of pharmaceutical compositions for treating oral lichen planus, can solve the problems of difficult-to-control impurity content, high drug taste, and high production cost, and achieve novel formula, good therapeutic effect, and simple composition Effect

Inactive Publication Date: 2014-08-06
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned disclosed patents have good clinical curative effect in the treatment of oral lichen planus, but the above-mentioned published patents have more medicinal flavors and higher production costs, and it is difficult to control their impurity content in industrialized large-scale production, so a clinical treatment is urgently needed. A pharmaceutical composition with less medicinal taste and significant clinical curative effect

Method used

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  • Pharmaceutical composition for treating oral lichen planus, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh raw materials Anemarrhena 10g, Phellodendron 5g, Rehmannia glutinosa 5g, Cornus officinalis 5g, Chinese yam 3g, Alisma 3g, add auxiliary materials 30g starch to granulate, magnesium stearate 2g, dextrin 20g, microcrystalline cellulose 20g, uniformly prepared Granules, compressed to obtain tablets.

Embodiment 2

[0026] Weigh raw materials Anemarrhena 60g, Phellodendron 50g, Rehmannia glutinosa 50g, Cornus officinalis 50g, Chinese yam 30g, Alisma 30g, add auxiliary materials starch 280g to granulate, magnesium stearate 20g, dextrin 100g, microcrystalline cellulose 100g, and evenly prepare Granules, compressed to obtain tablets.

Embodiment 3

[0028]Weigh raw materials Anemarrhena 20g, Phellodendron 10g, Rehmannia glutinosa 10g, Cornus officinalis 10g, Chinese yam 5g, Alisma 5g, add auxiliary materials 60g starch to granulate, magnesium stearate 5g, dextrin 30g, microcrystalline cellulose 30g, uniformly prepared Granules, compressed to obtain tablets.

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Abstract

The invention discloses a pharmaceutical composition for treating oral lichen planus, which is prepared from the following raw materials in parts by weight: 10-60 parts of rhizoma anemarrhenae, 5-50 parts of phellodendron bark, 5-50 parts of radix rehmanniae preparata, 5-50 parts of cornel, 3-30 parts of Chinese yam and 3-30 parts of rhizoma alismatis. The invention also discloses a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages of novel formula, simple components, low cost, obvious curative effect, no toxic or side effect, low tendency to generating tolerance and the like, and provides a new medicine option for clinically treating patients with oral lichen planus.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating oral lichen planus and a preparation method thereof. Background technique [0002] Oral lichen planus (OLP) is a chronic superficial inflammatory disease of the skin and mucous membranes. OLP has been reported in all races. OLP mainly occurs in adults over the age of 40, but young people and children also occur, accounting for about 2% to 3% of the total number of patients. The prevalence of OLP in adults is approximately 0.51%. Epidemiological research reports indicate that patients with oral lichen planus have a higher chance of cancer than normal people. It has been reported abroad that the rate of malignant transformation is 0.2% to 1.5%. Muzio et al. tracked 263 patients with oral lichen planus in Italy. During the follow-up period of 1 to 10 years, 10 of them developed cancer, and 5 of them developed cancer in multiple parts during the long-term follow-up, suggesting that ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P1/02
Inventor 颜家渝曾洁萍刘永家宁交陶黄映红梁琴何代玖
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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