37 results about "Behcet diseases" patented technology

The invention discloses an American cockroach medicinal composition for curing ulcers or ulcerative inflammation. The medicinal composition is mainly prepared from an active ingredient mixture prepared by mixing an American cockroach extract and montmorillonite powder. The weight part ratio of the American cockroach extract to the montmorillonite powder is equal to 0.8-1.2:0.5-6. A preparation method of the American cockroach medicinal composition for curing the ulcers or the ulcerative inflammation comprises the following steps of: preparing the American cockroach extract, mixing active ingredients, and preparing medicaments. The medicinal composition has simple preparation method, fully exerts effects of the American cockroach extract, and has obvious effects of effectively curing diseases such as oral ulcers, recurrent aphthous ulcers, oral lichen planus, oral mucosal injury (behcet disease, herpes simplex, leukoplakia, discoid lupus erythematosus, hand-foot-and-mouth disease, scalds, chemotherapy, radiotherapy and the like) caused by various reasons, reflux esophagitis, eophageal ucers, radiation esophagitis, ulcerative colitis, radiation proctitis, and diarrhea, and hematochezia with mucosal injury, and the like.

The present invention relates to a Chinese medicine composition, and especially a kind of Chinese medicine composition for treating lupus erythematosus, systemic scieroderm, dermatomyositis, panniculitis, behcets disease and connective tissue disease and its preparation process. The Chinese medicine composition is preferably prepared into dripping pill and soft capsule.

The invention discloses a medicament for treating behcet disease and a preparation method of the medicament. The medicament is mainly prepared from rhizoma curculiginis, tripterygium glycosides, honeysuckle stem, amomum tsao-ko, dark plum, gecko, dandelion, carpesium abrotanoides, talc, juncus effuses, feather cockscomb seed and the like in a certain weight ratio. The medicament has the efficacies of clearing heat, stopping blood, killing pests and diminishing inflammation, and has a quick effect and a good treatment effect when the medicament is used for treating the behcet disease; the behcet disease does not relapse after being cured.

The invention relates to a traditional Chinese medicine for treating intestinal Behcet disease. The traditional Chinese medicine is prepared from the following Chinese medicinal herbs in parts by weight: 10 parts of greyhair cipadessa root or leaf, 15 parts of pseudodrynaria coronans, 10 parts of all grass of anderson cirrhopetalum extract, 15 parts of phyllanthus urinaria, 15 parts of Ludwigia hyssopifo-lia (G.Don)Exekk, 9 parts of homlockleaved moonwort, 9 parts of cryptocoryne yunnanensis, 20 parts of pubescent pepper herb, 15 parts of ophioglossum vulgatum, 20 parts of pilea swinglei merr, 10 parts of saussurea arenaria and 15 parts of turnipshaped hawksbeard rootor herb. Clinical experiments prove that the traditional Chinese medicine is capable of safely and effectively treating the intestinal Behcet disease.

The invention relates to a traditional Chinese medicine for treating Behcet disease and Behcet syndrome. The traditional Chinese medicine serves as an effective drug to treat the Behcet disease and the Behcet syndrome. The technical scheme is that the traditional Chinese medicine comprises the following components by weight: 13g-17g of cordyceps sinensis, 13g-17g of coptidis rhizoma, 13g-17g of baical skullcap roots, 13g-17g of amoorcorn tree bark, 18g-22g of flos lonicerae, 18g-22g of fructus forsythiae, 11g-13g of radices paeoniae rubra, 11g-13g of moutan cortex, 11g-13g of radices lithospermi, 9g-11g of rhizoma anemarrhenae and 9g-11g of gypsum, wherein the cordyceps sinensis, the coptidis rhizoma, the baical skullcap roots, the amoorcorn tree bark, the flos lonicerae and the fructus forsythiae are smashed to powder, pass through a 300-mesh sieve and are mixed uniformly into fine powder for later use; the gypsum, the rhizoma anemarrhenae, the radices lithospermi, the moutan cortex and the radices paeoniae rubra are mixed together and then are immersed and decocted twice for 1.5 hours per time, solutions in the twice decoction are combined and then are concentrated into extract;and the fine powder and the extract are mixed to a medicament lump which is made to pills, and the pills are coated and packaged after being dried at 80 DEG C to be less than 5% in moisture. The traditional Chinese medicine can be used for treating the Behcet disease and the Behcet syndrome effectively, has a good curative effect, has no toxic and side effects, and is safe and reliable.

On the research basis that microbes of specific species are present in eyes of patients with different eye diseases, the invention discloses a method for establishing a model, and the method comprisesthe step of infecting a model carrier with the microbes. The model prepared by the method can be used for screening drugs for the eye diseases, and the eye diseases include senile macular degeneration, the behcet disease, the Vogt-Koyanagi-Harada syndrome, uveitis, retinopathy, xerophthalmia, sympathetic ophthalmia, trachoma, cataract, conjunctivitis, chalazion, glaucoma, muscae volitantes and the like.

The invention provides a use of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) or a fragment thereof in preparation of a reagent used for diagnosing Behcet disease (BD). The positive rate of the CTDP1 or the fragment thereof in a BD patient is remarkably higher than that of normal control, a Western blot verification result displays that an anti-CTDP1 antibody can be detected in the serum of the BD patient, which proves that the CTDP1 or the fragment thereof can be used for a detection marker of BD.

The invention relates to application of pharmaceutically-acceptable forms and derivatives of oxymatrines(oxymatrine, matrine and iosmatrine) to prepare medicines treating skin vasculitis (such as allergic cutaneous vasculitis, allergic purpura, erythema elevatum diutinum, acute febrile neutrophilic dermatosis, urticarial vasculitis, pustular vasculitis, polyarteritis nodosa, gnagrenous pyoderma, eosinophilic vasculitis, eosinophilic cellulitis, pigmented purpuric dermatoses, wegner granulomatosis, behcet disease, erythema nodosum, and erythema induratum).

The invention discloses a traditional Chinese medicine composition for treating behcet disease. The crude medicine is characterized by comprising the following components according to weight ratio: 15 g of honeysuckle, 6 g of radix saposhnikoviae, 9 g of agastache rugosus, 6 g of moutan bark, 9 g of scutellaria baicalensis, 6 g of coptis chinensis, 20 g of hedyotis diffusa, 9 g of dried rehmannia root, 20 g of gypsum and 6 g of liquorice. The preparation method comprises the following steps: weighing the medicines according to weight ratio, soaking, brewing and filtering the medicines by water so as to be prepared into decoction. The traditional Chinese medicine provided by the invention is easily obtained and is low in cost; the medicines are matched reasonably to achieve synergistic effect, so the composition can achieve the purposes of heat-clearing and damp-drying drug, purging intense heat and detonicating, invigorating the circulation of blood, clearing stasis, tonifying spleen yiqi, nourishing yin, changing saprophytic muscle, stopping pain and dispersing swelling. The medicine composition has the advantages of no allergy, safety in use, strong pertinence, good effect, high cure rate and the like.

The invention is an application of FK-506 macrolide antibiotic and medicine which can be decomposed biologically automatically which are used as planted slow release medicines in eyes. The medicine can maintain a fixed intensity and shape after release, and it can be decomposed naturally in vivo, thus it can be absorbed and discharged out of body, it will not become abnormal and generates stimulation to body, thus it need not to be taken out in the secondary operation. The period of the medicine is from two weeks to half year, the dose needed is little, it will not be affected by tears and dilution, it can release medicine slowly in a long period; it can be applied to prevent the eye diseases and cure repulsion reaction after cornea transplantation, at the same time, it can cure chronic uveitis, behcets disease, stevene-Johnson syndrome, and other diseases.

The invention belongs to a pure Chinese medicine preparation and in particular relates to a traditional Chinese medicine composition used for drying dampness and expelling toxicity. The traditional Chinese medicine composition can be used for treating Behcet disease, prostatosis and piles. The traditional Chinese medicine composition provided by the invention is taken orally, and the traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-25 parts of polyporus, 10-20 parts of poria cocos, 5-12 parts of rheum officinale, 3-8 parts of monkshood, 15-25 parts of ruddle and 10-14 parts of honewort. The traditional Chinese medicine composition provided by the invention is a pure Chinese medicine preparation with the effects of clearing heat, drying dampness and eliminating toxicity, can be used for treating diseases such as Behcet disease, prostatosis and piles which are caused by the internal reasons, produces no toxic or side effect to a human body and can take effect quickly; recurrence probability is low; meanwhile, the traditional Chinese medicine composition provided by the invention is simple in composition and has good treatment effect; besides, an adopted preparation method is simple, and production cost is low; the traditional Chinese medicine composition provided by the invention can be easily accepted by a patient; and related experiments carried out on the traditional Chinese medicine composition are completed.

The invention discloses a Chinese patent medicine for treating a behcet disease and a preparation method of the Chinese patent medicine. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 30-35 parts of honeysuckle, 6-9 parts of coptis chinensis, 20-30 parts of astragalus membranaceus, 15-30 parts of smilax glabra, 15-20 parts of bletilla striata, 12-15 parts of leech, 9-12 parts of spina gleditsiae and 12-15 parts of raw liquorice. The preparation method comprises a step of refining the Chinese patent medicine by extracting thick paste. The medicine effect can be effectively improved; and the Chinese patent medicine is relatively convenient to take. The medicine disclosed by the invention has the efficacies of tonifying qin, detoxifying, resolving dampness and dredging collaterals, is capable of improving dental ulcer, pathogenesis, vulvav ulcer and skin rash of patients with the behcet disease, and has a significant treatment effect on system scleredema; the ESR and CRP content of serum is reduced; and the total effective rate is 91.1%.

The invention relates to a medical application of caper or caper extract, and specifically provides an application of the caper or caper extract in preparing a medicine or health care product for reducing hepatotoxicity of common threewingnut root, tripterygium glycosides or triptolide, and also provides a composition and an application thereof in preparing a medicine or health care product for preventing and treating rheumatic arthritis, glomerulonephritis, nephrotic syndrome, lupus erythematosus, Sjogren's syndrome, Behcet disease, eczema, psoriasis, leprosy, scabies, stubborn dermatitis, Hashimoto's thyroiditis or tumor, wherein the composition is prepared from a component i) and a component ii), wherein the component i) is caper or caper extract; the component ii) is tripterygium glycosides or triptolide.

The invention discloses a traditional Chinese medicine for treating behcet disease. The traditional Chinese medicine comprises leech, luffa stem, rhizoma drynariae, corydalis amabilis, Shuliang yam rhizome, conmon clubmoss herb, kadsura longipedunculata, trogopterus dung, dog bones, curcuma rhizome, semen impatientis, cyathea spinulosa walls, fortune holly fern rhizome, indigo naturalis, bupleurum falcatum, orostachys fimbriatus, root of chinese pulsatilla, and setcreasea purpurea. The traditional Chinese medicine takes pure natural Chinese herbal medicines as raw materials, can realize simultaneous treatment of principal and subordinate symptoms, and has the advantages of obvious curative effect, no toxicity, and no side effect.

The invention relates to a traditional Chinese medicine composition for treating Behcet diseases, which can effectively solve the problem of a medicine for Behcet disease treatment. The technical scheme is that the traditional Chinese medicine composition is prepared from the following components in parts by weight: 60-100 parts of adzuki beans, 10-30 parts of rhizoma cimicifugae, 20-60 parts of angelica, 20-40 parts of prepared turtle shells, 10-30 parts of Sichuan peppers, 4-8 parts of realgar, 20-40 parts of dogwood and 10-30 parts of licorice roots. The traditional Chinese medicine composition is prepared through the following steps: soaking the adzuki beans into water until buds with a length of 0.5-1cm are germinated, filtering out water, and taking the adzuki beans for standby application; mixing the germinated adzuki beans, the rhizoma cimicifugae, the angelica, the prepared turtle shells, the Sichuan peppers, the realgar, the dogwood and the licorice roots, and adding water with a weight 8-10 times as large as that of the obtained mixture; decocting the obtained mixture two times, 40-90 minutes each time; merging decoctions, and filtering the merged decoctions so as to obtain filter liquor; carrying out reduced-pressure concentration on the filter liquor until a clean cream with a relative density of 1.10-1.30 at a temperature of 50 DEG C is obtained; and adding a supplementary material with a weight accounting for 20-60% of the weight of the clean cream so as to prepare a clinically applicable traditional Chinese medicine composition preparation. The traditional Chinese medicine composition disclosed by the invention is scientific in formula, easy to produce, low in cost, good in curative effect, less in toxic or side effect and obvious in advantages, and can be effectively applied to the clinical treatment of Behcet diseases, therefore, the traditional Chinese medicine composition is an innovation on traditional Chinese medicines.

The invention relates to a Chinese medicine combination for treating Behcet disease, which is made from coptis chinensis, radix rehmanniae, prepared rhizome of rehmannia, gentian, scutellaria, baked licorice, cortex moutan, dentrobium, rhizoma anemarrhenae, pulp of cornus, codonopsis pilosula, atractylodes, honeysuckle stem, dandelion, gentian, dyers woad leaf and / or acceptable vectors in medicine. The invention also relates to the preparation method of the Chinese medicine combination. The Chinese medicine combination of the invention has the functions of removing damp-heat, nourishing liver and kidney, purging fire to eliminate toxin, etc. and is used for symptoms caused by the inflammation of fine vascular, such as oral and vulvar ulcers, ophthalmia, skin damages, etc.

A discriminating model for a Crohn's disease and an intestinal Behcet disease comprises scores of corresponding indexes in at least two aspects of clinical representation, an endoscope characteristicand an imaging characteristic and the summation of scores of the corresponding indexes. The indexes of the clinical representation comprise genitals ulcer and skin lesion; wherein the indexes of the endoscope characteristic comprise quasi-circular ulcer and longitudinal ulcer; the total number of ulcers is higher than 5; inflammatory polyp; wherein the indexes of the imaging characteristic comprise severe enhancement of a mucosal surface and fat density increase around a mesentery; wherein the Crohn's disease is diagnosed when the total number is higher than 1, and the intestinal Behcet disease is diagnosed when the total number is lower than or equal with 1. Through the model of the invention, discriminating of the Crohn's disease and the intestinal Behcet disease can be effectively realized. The discriminating model has advantages of simple operation, high speed and high accuracy. Furthermore the invention discloses a constructing method and a verifying method of the model, thereby ensuring high effectiveness of the model. Furthermore the invention designs a corresponding discriminating tool for more visually and quickly understanding a disease condition.

A [5-chloro-6-phenyl-2-(4-trifluoromethylphenyl)-4-pyrimidinyl-amino]acetamide derivative of the formula (I):wherein R1 is a methyl group or a cyclopropyl group, and a pharmaceutical composition containing the same. Said compounds exhibit a potent anti-rheumatoid activity and show low toxicity, and hence, they are useful as an agent for prophylaxis or treatment of immuno inflammatory diseases such as rheumatoid diseases (e.g., rheumatoid arthritis, Behcet disease, ankylosing spondylitis, etc.) and autoimmune diseases (e.g., multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, etc.).

The invention relates to a traditional Chinese medicine for treating an intestinal behcet disease. The medicine is prepared by using the following medicinal materials in parts by weight: 10 parts of dryopteris atrata, 12 parts of bacopa monnieri, 16 parts of vitis heyneana, 8 parts of gentiana pubigera Marq., 10 parts of begonia palmate, 14 parts of tongoloa root, 12 parts of piper hainanense, 13 parts of dracocephalum rupestre hance, 12 parts of acorus gramineus soland, 11 parts of hainan ervatamia root, 11 parts of rungia pectinata, 12 parts of viola inconspicua, 14 parts of anisomeles indica, 16 parts of platanthera japonica, 16 parts of vaccinium fragile franch, 14 parts of carex rigescens, 10 parts of ficus variolosa, 12 parts of adonis amurensis and 14 parts of symplocos paniculata root. Proved by clinical experiments, the traditional Chinese medicine disclosed by the invention is capable of safely and effectively treating the intestinal behcet disease.

The invention relates to a traditional Chinese medicine composition for treating Behcet diseases, which can effectively solve the problem of a medicine for Behcet disease treatment. The technical scheme is that the traditional Chinese medicine composition is prepared from the following components in parts by weight: 60-100 parts of adzuki beans, 10-30 parts of rhizoma cimicifugae, 20-60 parts of angelica, 20-40 parts of prepared turtle shells, 10-30 parts of Sichuan peppers, 4-8 parts of realgar, 20-40 parts of dogwood and 10-30 parts of licorice roots. The traditional Chinese medicine composition is prepared through the following steps: soaking the adzuki beans into water until buds with a length of 0.5-1cm are germinated, filtering out water, and taking the adzuki beans for standby application; mixing the germinated adzuki beans, the rhizoma cimicifugae, the angelica, the prepared turtle shells, the Sichuan peppers, the realgar, the dogwood and the licorice roots, and adding water with a weight 8-10 times as large as that of the obtained mixture; decocting the obtained mixture two times, 40-90 minutes each time; merging decoctions, and filtering the merged decoctions so as to obtain filter liquor; carrying out reduced-pressure concentration on the filter liquor until a clean cream with a relative density of 1.10-1.30 at a temperature of 50 DEG C is obtained; and adding a supplementary material with a weight accounting for 20-60% of the weight of the clean cream so as to prepare a clinically applicable traditional Chinese medicine composition preparation. The traditional Chinese medicine composition disclosed by the invention is scientific in formula, easy to produce, low in cost, good in curative effect, less in toxic or side effect and obvious in advantages, and can be effectively applied to the clinical treatment of Behcet diseases, therefore, the traditional Chinese medicine composition is an innovation on traditional Chinese medicines.

The invention relates to a method for detecting behcet diseases. The method comprises the steps that data of 15 behcet disease HLA allelic gene polymorphism types is collected, a behcet disease HLA allelic gene polymorphism database is established, according to the 15 behcet disease HLA allelic gene polymorphism types in the behcet disease HLA allelic gene polymorphism database, 15 behcet diseaseHLA typing specific primers are designed, after a to-be-detected DNA sample is extracted, the behcet disease HLA typing specific primers and the to-be-detected DNA sample are added into a sequencing chip, amplification and sequencing are performed on the to-be-detected DNA sample, the HLA type of the to-be-detected DNA sample in a sequencing result is compared with the 15 behcet disease HLA allelic gene polymorphism types in the database, a comparison result is judged by a physician, and the auxiliary diagnosis of the behcet diseases is achieved.

The invention provides a behcet disease marker microorganism and application thereof, and the behcet disease marker microorganism comprises a first microorganism set, so that the invention further provides a kit which comprises a reagent suitable for detecting at least one strain in the first microorganism set, the first microorganism set is prepared from the following strains: Atkinsonlatexis, Claviceppaspali, Corynebacterium glutamicum, Epichia pastoris (Epichia pastoris), Macrophaphaeolina, Stenotrophomonas maltophilia and Stenotrophomonas rhizophila, and the first microorganism set is prepared from the following strains: Atkinsonlatexis, Claviceppaspali, Corynebacterium glutamicum, Epichia pastoris (Epichia pastoris), Stenotrophomonas maltophilia, Stenotrophomonas rhizophila, Stenotrophomonas sp., Stenotrophomonas sp., Stenotrophomonas sp., Stenotrophomonas sp. And Stenotrophomonas sp. The marking microorganism provided by the invention has significant difference in abundance between healthy people and behcet disease patients, and can be used as a marker for detecting and / or treating behcet disease.

The present invention relates to the medical use of Capers or Capers extracts, specifically provides Capers or Capers extracts in the preparation of medicines for reducing tripterygium wilfordii, tripterygium glycosides or triptolide hepatotoxicity or The application in health products also provides a composition and its preparation for preventing and treating rheumatoid arthritis, glomerulonephritis, nephrotic syndrome, lupus erythematosus, dry eye syndrome, Behcet's disease, eczema, psoriasis , leprosy, scabies, ringworm, Hashimoto's thyroid or tumor medicine or health care products, the composition comprises component i) and component ii), and the component i) is selected from: Capers or the extract of capers; the component ii) is selected from: tripterygium glycosides or triptolide.

The invention relates to the technical field of medicine, and particularly relates to a compound cortex phellodendri medicinal preparation, a preparation method and application. The compound cortex phellodendri medicinal preparation is prepared from fructus forsythiae, cortex phellodendri, lonicera japonica, dandelion, centipede, menthol, 20% chlorhexidine gluconate, stevioside, Tween 80 and propylene glycol. According to the compound cortex phellodendri medicinal preparation, the formula is improved on the basis of an existing compound cortex phellodendri liquid liniment, a medicine with a good treatment effect on oral ulcer caused by the behcet disease is obtained, the curative effect is remarkable, and the problems that the existing compound cortex phellodendri liquid liniment is bitter in taste, difficult to take orally and poor in antibacterial effect are solved.

The invention belongs to a pure Chinese medicine preparation and in particular relates to a traditional Chinese medicine composition used for drying dampness and expelling toxicity. The traditional Chinese medicine composition can be used for treating Behcet disease, prostatosis and piles. The traditional Chinese medicine composition provided by the invention is taken orally, and the traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-25 parts of polyporus, 10-20 parts of poria cocos, 5-12 parts of rheum officinale, 3-8 parts of monkshood, 15-25 parts of ruddle and 10-14 parts of honewort. The traditional Chinese medicine composition provided by the invention is a pure Chinese medicine preparation with the effects of clearing heat, drying dampness and eliminating toxicity, can be used for treating diseases such as Behcet disease, prostatosis and piles which are caused by the internal reasons, produces no toxic or side effect to a human body and can take effect quickly; recurrence probability is low; meanwhile, the traditional Chinese medicine composition provided by the invention is simple in composition and has good treatment effect; besides, an adopted preparation method is simple, and production cost is low; the traditional Chinese medicine composition provided by the invention can be easily accepted by a patient; and related experiments carried out on the traditional Chinese medicine composition are completed.

The invention relates to a traditional Chinese medicine for treating behcet disease. The traditional Chinese medicine for treating behcet disease is characterized by comprising the following medicinal materials according to parts by weight: 50g of liquorice, 50g of oldenlandia diffusa, 20g of glossy privet fruit, 30g of carpesium abrotanoides, 30g of feverfew root, 30g of rhizoma phragmitis, 30g of field pennycress, 6g of rheum officinale, 20g of rhizoma sparganii, 5g of peach kernel, 30g of ginseng, 15g of cortex moutan, 20g of radices trichosanthis, and 20g of ground beetle. Experiments prove that the traditional Chinese medicine can treat the behcet disease safely and effectively.