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Medical application of caper or caper extract

A technology of capers and extracts, applied in the field of medicinal use of capers or capers extracts, to achieve significant effects and reduce the amount of medicinal materials

Active Publication Date: 2019-02-05
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is currently no report that the combination of capers extract, tripterygium wilfordii, tripterygium glycosides, and triptolide can increase the efficiency and attenuate the toxicity.

Method used

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  • Medical application of caper or caper extract
  • Medical application of caper or caper extract
  • Medical application of caper or caper extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 capers water extract preparation

[0035] Take the dried and crushed caper fruit, weigh 5kg, add water and reflux to extract for 3h×3 times (8 times the amount of water for the first time, and 6 times the amount of solvent for the last two times), combine the reflux liquid, and recover under reduced pressure to a concentrated extract , freeze-dried to obtain a dry paste, and set aside.

Embodiment 2

[0036] The preparation of the different extracts of embodiment 2 Capers water extract

[0037] Take the dried and crushed caper fruit, weigh 1kg, add water and reflux to extract 3h×3 times (8 times the amount of water for the first time, and 6 times the amount of solvent for the last two times), combine the reflux liquid, recover under reduced pressure to an appropriate amount, and separate Petroleum ether extract (SY), ethyl acetate extract (YS), n-butanol extract (ZD) and water fraction (ST) were obtained by petroleum ether (60-90°C), ethyl acetate and n-butanol extraction respectively. . The four different extraction fractions were concentrated into extracts respectively, and freeze-dried to obtain dry extracts for future use.

Embodiment 3

[0038] Embodiment 3 Capers ethanol extract preparation

[0039] Take the dried and crushed caper fruit, weigh 5kg, heat and reflux extract with 85% ethanol for 3h×3 times (the first time is 7 times the amount of 85% ethanol, and the last two times are 5 times the amount of solvent), combine the reflux liquid, and decompress Recovered to a concentrated extract, freeze-dried to obtain a dry extract, which is the ethanol extract of capers used herein.

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Abstract

The invention relates to a medical application of caper or caper extract, and specifically provides an application of the caper or caper extract in preparing a medicine or health care product for reducing hepatotoxicity of common threewingnut root, tripterygium glycosides or triptolide, and also provides a composition and an application thereof in preparing a medicine or health care product for preventing and treating rheumatic arthritis, glomerulonephritis, nephrotic syndrome, lupus erythematosus, Sjogren's syndrome, Behcet disease, eczema, psoriasis, leprosy, scabies, stubborn dermatitis, Hashimoto's thyroiditis or tumor, wherein the composition is prepared from a component i) and a component ii), wherein the component i) is caper or caper extract; the component ii) is tripterygium glycosides or triptolide.

Description

technical field [0001] The present invention relates to the field of medicine and health care products, in particular to the medical use of capers or capers extracts, and the capers and capers extracts of the present invention can be used to prepare Tripterygium wilfordii, Tripterygium glycosides tablets, Tripterygium wilfordii Drugs or health care products with enhanced efficacy and reduced toxicity. Background technique [0002] Tripterygium Wilfordii (Tripterygium Wilfordii Hook.f.) and its extract Tripterygium glycosides are commonly used clinical anti-rheumatic drugs, which can be used to treat rheumatoid arthritis, primary glomerulonephropathy, nephrotic syndrome, purple scar And traditional Chinese medicine for lupus nephritis, lupus erythematosus and other diseases. However, they can also cause many adverse reactions, such as gastrointestinal reactions, liver and kidney toxicity, and cardiovascular damage. They are one of the most serious hepatotoxic Chinese medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/37A61K31/585A61P1/16A61P13/12A61P17/00A61P19/02A61P29/00A61P35/00A61P17/06A61P31/10
CPCA61K31/585A61K36/185A61K36/37A61P1/16A61P13/12A61P17/00A61P17/06A61P19/02A61P29/00A61P31/10A61P35/00A61K2300/00
Inventor 杨涛刘成海
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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