Slow-releasing medicine inplanted in eye and use thereof
A slow-release drug and drug technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor drug efficacy, unstable drug concentration in the eye, and short sustained drug release time, and achieve good tissue compatibility , Avoid causing high blood pressure, avoiding the effect of toxic damage
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0020] Take 5 parts of lactic acid / glycolic acid copolymer (PLGA, molecular weight 6-110,000), dissolve it with 40 parts of chloroform, add 20 parts of FK-506 powder, stir well, inject it into a polytetrafluoroethylene mold, and wait for the chloroform to volatilize , and after complete drying, the film containing the lactic acid / glycolic acid copolymer of FK-506 is taken off from the polytetrafluoroethylene mold, and the solvent is further removed under vacuum at room temperature for 72 hours to obtain a thickness of 1.5-2.0 mm. A flaky film with a nanoscale pore structure containing FK-506 lactic acid / glycolic acid copolymer, and then punched with a die with a pore diameter of 1.5-2.0 mm to a thickness of 1.5-2.0 mm and a diameter of 1.5-2.0 mm formulation of FK-506. The FK-506 preparation was sterilized by fumigation with ethylene oxide for 24 hours, and then placed in the anterior chamber of the rabbit for another week.
[0021] The results of postoperative macroscopic ob...
Embodiment 2
[0024] Take 3 parts of poly DL-lactic acid (PDLLA, molecular weight 30,000-60,000), 20 parts of dioxane and 2 parts of FK-506 drug, dissolve and mix evenly, pour into a polytetrafluoroethylene mold, put it into a freeze dryer, and Frozen state and desolvation under vacuum for 72 hours, to obtain a sheet-shaped drug film with a thickness of 1.5-2.0 mm and a pore diameter of about 50 microns, and then use a die with a pore diameter of 1.5-2.0 mm to punch it into a film with a thickness of 1.5-2.0 mm and a diameter of 1.5-2.0 mm of FK-506 formulation. The FK-506 preparation was sterilized by fumigation with ethylene oxide for 24 hours, and then placed for another week, and implanted into the anterior chamber of the rabbit eye in the same way as in method 1.
[0025] The results of postoperative macroscopic observation and local histopathological examination showed that the FK-506 release system has good intraocular biocompatibility. Within 14 weeks after implantation, FK-506 can ...
Embodiment 3
[0027]According to the method and steps of Example 1, but using 3 parts of (glycolic acid / lactic acid / caprolactone terpolymer (PGLC, molecular weight 80,000), 18 parts of dichloromethane and FK prepared by the method of Chinese invention patent ZL 99105984.0 9 parts of -506 medicines are made the block thing that is the nanopore structure, and the punching die that is 2.0 millimeters is punched into the medicine stick that diameter is 2 millimeters with aperture again.This medicine stick is cut into the sheet preparation that requires thickness and then further in Keep in a vacuum oven at room temperature for 48 hours to completely remove the solvent, and then carry out ethylene oxide fumigation and sterilization for 24 hours. Place it for 1 week and then implant it into the anterior chamber of the rabbit eye in the same way as in Example 1.
[0028] Postoperative macroscopic observation and local histopathological examination showed that the FK-506 release system has good intr...
PUM
Property | Measurement | Unit |
---|---|---|
pore size | aaaaa | aaaaa |
diameter | aaaaa | aaaaa |
thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com