Medical composition for treating oral mucosa diseases and preparation method and purpose of medical composition

A technology of oral mucosa and composition, which is applied in the field of pharmaceutical composition for the treatment of oral mucosal diseases and its preparation, which can solve the problems of difficult-to-control impurity content, single action direction, and large number of medicinal flavors, and achieve novel formula, simple composition, and easy operation. simple effect

Inactive Publication Date: 2019-07-19
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Theoretically speaking, the above-mentioned disclosed patent formula has good clinical efficacy in the treatment of oral lichen planus, periodontitis, etc., but the above-mentioned formula has a large number of medicinal flavors, a single direction of action, and relatively high production costs. It is difficult to control its impurity content in large-scale production, so there is an urgent need for a pharmaceutical composition with less medicinal taste, good balance, and significant clinical efficacy
At present, there is no relevant report on the treatment of oral mucosal diseases with Bupleurum, Cimicifuga, Radix Astragali, Poria, Ginseng, Radix Glycyrrhizae, Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome, Atractylodes Atractylodes Rhizome, Fructus Aurantii, Coptidis Rhizome, Scutellaria Baicalensis, Cinnamon, and Cistanche.

Method used

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  • Medical composition for treating oral mucosa diseases and preparation method and purpose of medical composition
  • Medical composition for treating oral mucosa diseases and preparation method and purpose of medical composition
  • Medical composition for treating oral mucosa diseases and preparation method and purpose of medical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0027] (1) Raw materials: Bupleurum 5g, Cimicifuga 3g, Astragalus 8g, Poria 3g, Ginseng 3g, Radix Glycyrrhizae 3g, Atractylodes 3g, Atractylodes macrocephala 3g, Citrus aurantii 3g, Coptidis 3g, Scutellaria baicalensis 3g, Cinnamon 3g, Cistanche 5g.

[0028] (2) Preparation method:

[0029] Step 1: Weigh the crude drug according to the above weight ratio, first mix all the raw materials, add 6-8 times the amount of the medicinal material, soak in water for 0.5-1 hour, then decoct for 0.5-1 hour, filter to obtain the decoction, medicinal residue Standby; add 6 to 8 times the amount of medicinal material to decoct the dregs for 1 to 1.5 hours, filter to obtain a decoction, and discard the dregs; combine the two decoctions and concentrate to form an extract, and then vacuum the extract Dried to obtain a dry paste, the dry paste is crushed.

[0030] Step 2: Add 80 g of auxiliary material...

Embodiment 2

[0031] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0032] (1) Raw materials: Bupleurum 50g, Cimicifuga 30g, Astragalus 80g, Poria 30g, Ginseng 30g, Zhilicorice 30g, Atractylodes 30g, Atractylodes macrocephala 30g, Citrus aurantium 30g, Coptis chinensis 30g, Scutellaria baicalensis 30g, Cinnamon 30g, Cistanche 50g.

[0033] (2) Preparation method: Step 1 is the same as in Example 1, and Step 2: add 400 g of auxiliary materials starch to granulate, 40 g of magnesium stearate, 200 g of dextrin, and 200 g of microcrystalline cellulose, uniformly prepare granules, compress into tablets, and obtain tablets .

Embodiment 3

[0034] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0035] (1) Raw materials: Bupleurum 8g, Cimicifuga 5g, Astragalus 10g, Poria 5g, Ginseng 5g, Licorice 5g, Atractylodes 5g, Atractylodes 5g, Citrus aurantium 5g, Coptidis 5g, Scutellaria baicalensis 5g, Cinnamon 5g, Cistanche 8g.

[0036] (2) Preparation method: Step 1 is the same as in Example 1, and Step 2: add 100 g of auxiliary materials starch to granulate, 5 g of magnesium stearate, 30 g of dextrin, and 30 g of microcrystalline cellulose, uniformly prepare granules, compress into tablets, and obtain tablets .

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Abstract

The invention provides a medical composition for treating oral mucosa diseases. The medical composition is prepared from the following raw material medicines in parts by weight of 5-50 parts of radixbupleuri, 3-30 parts of rhizoma cimicifugae, 8-80 parts of radix astragali, 3-30 parts of poria cocos, 3-30 parts of ginseng, 3-30 parts of radix glycyrrhizae preparata, 3-30 parts of swordlike atractylodes rhizomes, 3-30 parts of bighead atractylodes rhizomes, 3-30 parts of fructus aurantii, 3-30 parts of rhizoma coptidis, 3-30 parts of radix scutellariae, 3-30 parts of cinnamon and 5-50 parts ofherba cistanches. The invention also further discloses a preparation method and purpose of the medical composition. The traditional Chinese medicine composition provided by the invention is novel informula and simple in composition, has the advantages of being low in cost, notable in treatment effects, free from toxic and side effects and the like, tolerance is not easy to produce, and a new medication selection is provided for clinical treatment of the oral mucosa diseases of oral lichen planus, dental ulcer or chronic periodontitis and the like.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating oral mucosal diseases, a preparation method and application thereof. Background technique [0002] Oral mucosal disease refers to the damage of the mucous membrane in the oral cavity. Specific symptoms include ulceration of the mouth and tongue, dry and cracked tongue, etc., which often lead to oral diseases such as oral lichen planus, oral ulcers, stomatitis, and cheilitis. It belongs to the category of common and frequently-occurring diseases in clinical practice. . [0003] Oral lichen planus mainly occurs in adults over the age of 40, and its prevalence is about 0.51%. According to epidemiological surveys, the malignant transformation rate of this disease is about 0.2% to 1.5%, and WHO has defined it as a precancerous state disease. At present, Western medicine mostly uses glucocorticoids, immune enhancers, vitamins, etc. for the treatment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/02
CPCA61K36/076A61K36/233A61K36/258A61K36/284A61K36/481A61K36/484A61K36/539A61K36/54A61K36/64A61K36/71A61K36/718A61K36/752A61P1/02A61K2300/00
Inventor 颜家渝王定平梁琴余剑锋李光勇赵君硕刘朴艾福帅王春闻炎高彩玲
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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