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Application of traditional Chinese medicine in preparation of drugs for preventing or treating oral lichen planus

A technology of oral lichen planus and traditional Chinese medicine preparations, which is applied in the field of traditional Chinese medicine preparations, can solve problems such as teratogenicity, hair loss, contraindications, etc., and achieve significant preventive and therapeutic effects and good safety effects

Active Publication Date: 2015-08-12
苏州科豪生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, Western medicine is mainly used for the treatment of oral lichen planus. Although it can alleviate the disease to a certain extent, there are some side effects, such as causing dry lips, hair loss, etc., and even have teratogenic effects
Moreover, Western medicine has certain limitations, and most Western medicines have their prohibited population or symptoms that are not applicable.

Method used

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  • Application of traditional Chinese medicine in preparation of drugs for preventing or treating oral lichen planus
  • Application of traditional Chinese medicine in preparation of drugs for preventing or treating oral lichen planus
  • Application of traditional Chinese medicine in preparation of drugs for preventing or treating oral lichen planus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of Chinese medicine preparation is provided in this example, the dosage form of this Chinese medicine preparation is a capsule, and the formula is as follows:

[0025] Rehmannia glutinosa 14%, Polygonum multiflorum 9%, Ligustrum lucidum 6%, Eclipta 11%, Chuanxiong 5%, Chinese yam 8%, American ginseng 10%, Panax ginseng 11%, Ganoderma lucidum 11%, Lycium barbarum 9%, Poria cocos 6% .

[0026] The preparation method is as follows: decoct the above-mentioned raw materials twice, adding 8 times the amount of water each time for 1.5 hours each time, filtering the decoction, combining the filtrate, concentrating the filtrate under reduced pressure, drying under reduced pressure, pulverizing, passing through a 80-mesh sieve, Obtain the extract, then use 85% ethanol to make soft material from the above extract, granulate with 16-mesh sieve, dry at 60°C for 4-5 hours, granulate with 14-mesh sieve, and then pack into No. 0 capsules to obtain the capsule.

Embodiment 2

[0028] A kind of Chinese medicine preparation is provided in this example, the dosage form of this Chinese medicine preparation is capsule, and the formula of Chinese medicine preparation is as follows:

[0029] Rehmannia glutinosa 15%, Polygonum multiflorum 12%, Ligustrum lucidum 9%, Eclipta 14%, Chuanxiong 3%, Chinese yam 6%, American ginseng 12%, Panax ginseng 9%, Ganoderma lucidum 9%, Lycium barbarum 7%, Poria cocos 4% .

[0030] The preparation method is the same as in Example 1.

Embodiment 3

[0032] A kind of Chinese medicine preparation is provided in this example, the dosage form of this Chinese medicine preparation is capsule, and the formula of Chinese medicine preparation is as follows:

[0033] Rehmannia glutinosa 8%, Polygonum multiflorum 9%, Ligustrum lucidum 3%, Eclipta 12%, Chuanxiong 4%, Chinese yam 10%, American ginseng 11%, Panax ginseng 10%, Ganoderma lucidum 12%, Lycium barbarum 9%, Poria cocos 12% .

[0034] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to a traditional Chinese medicine preparation, a pharmaceutical composition containing the same, and an application of the traditional Chinese medicine preparation and pharmaceutical composition in the preparation of drugs for preventing or treating oral lichen planus. The traditional Chinese medicine preparation comprises the following components in percentage by weight: 8 to 18% of prepared rehmannia root, 5 to 14% of prepared fleece flower root or polygonatum rhizome, 3 to 12% of ligustrum lucidum, 6 to 16% of yerbadetajo herb, 2 to 11% of ligusticum wallichii, 4 to 14% of Chinese yam, 6 to 15% of America ginseng, 6 to 15% of ginseng, 7 to 16% of lucid ganoderma, 5 to 15% of wolfberry, and 3 to 12% of poria cocos. The provided traditional Chinese medicine preparation or pharmaceutical composition containing the same has a prominent preventive and curative effect on oral lichen planus.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, a pharmaceutical composition containing the traditional Chinese medicine preparation and their use in preparing medicines for preventing or treating oral lichen planus. Background technique [0002] Oral lichen planus is a common chronic oral mucosal disease, which is generally not contagious. Epidemiological surveys suggest that oral lichen planus is a precancerous lesion. The disease is considered as a T cell-mediated autoimmune disease, and immune dysfunction plays an important role in its occurrence and development. Current studies have shown that its pathogenesis is closely related to immune factors, and certain antigens act on the stratum corneum cells of the oral mucosa to generate cellular immune responses. Further deterioration of oral lichen planus may lead to oral squamous cell carcinoma, endangering the life and health of patients. [0003] In the prior art, Western medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P1/02
Inventor 陈永石
Owner 苏州科豪生物制品有限公司
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