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Pharmaceutical composition for treating oral lichen planus and application of pharmaceutical composition

A technology for oral lichen planus and a composition is applied in the field of pharmaceutical compositions for the treatment of oral lichen planus, which can solve the problems of increased number of patients, easy recurrence, and repeated attacks, and achieve the effects of reducing the area of ​​mucosal damage and relieving pain.

Active Publication Date: 2014-09-24
河南御艾堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term external use of glucocorticoids often produces adverse reactions such as local atrophy, infection, and telangiectasia. The curative effects of antibiotic solution gargling and 0.1% retinoic acid ointment are not ideal
[0003] Because oral lichen planus is often accompanied by blisters, ulceration, and erosion of the oral mucosa, the patient feels obvious spontaneous pain or trigger pain when eating, and the clinical symptoms are severe, so it is difficult to treat. The traditional treatment method has poor curative effect and is prone to recurrence. Patients with increased mental stress
At the same time, because of its complex etiology, unstable condition, and frequent recurrent attacks, there are currently no particularly effective drugs and methods at home and abroad.

Method used

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  • Pharmaceutical composition for treating oral lichen planus and application of pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 Chinese medicine coating agent

[0016] Weigh 32 parts of Scrophularia scrophulariae, 32 parts of Chinese rose, 16 parts of raw land and 8 parts of willow root, combine them, add water to decoct twice, add water for the first time to 10 times the weight of medicinal materials, decoct for 1.5h, and add water for the second time 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa at 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v / v) ethanol to make the extract containing The alcohol content reached 75% (v / v), stirred, stood still for 24 hours, filtered, and the filtrate was concentrated under reduced pressure at 0.07MPa and 65°C until the relative density was 1.25 at 65°C, and the ethanol was recovered to obtain a concentrated solution. Spray-dry the concentrate (conditions are that the air inlet temperature is 100°C, the outlet air tem...

Embodiment 2

[0018] The preparation of embodiment 2 Chinese medicine coating agent

[0019] Weigh 38 parts of Scrophularia scrophulariae, 30 parts of Chinese rose, 20 parts of raw land, and 10 parts of willow root, combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal material, decoct for 1.5h, and add water for the second time. 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa at 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v / v) ethanol to make the extract containing The alcohol content reached 75% (v / v), stirred, stood still for 24 hours, filtered, and the filtrate was concentrated under reduced pressure at 0.07MPa and 65°C until the relative density was 1.25 at 65°C, and the ethanol was recovered to obtain a concentrated solution. Spray-dry the concentrate (conditions are that the air inlet temperature is 100°C, the outlet a...

Embodiment 3

[0021] The preparation of embodiment 3 Chinese medicine coating agent

[0022] Weigh 25 parts of Scrophularia scrophulariae, 28 parts of Chinese rose, 12 parts of raw land, and 6 parts of willow root, combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, and add water for the second time. 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa at 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v / v) ethanol to make the extract containing The alcohol content reached 75% (v / v), stirred, stood still for 24 hours, filtered, and the filtrate was concentrated under reduced pressure at 0.07MPa and 65°C until the relative density was 1.25 at 65°C, and the ethanol was recovered to obtain a concentrated solution. Spray-dry the concentrate (conditions are that the air inlet temperature is 100°C, the out...

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Abstract

The invention discloses a pharmaceutical composition for treating oral lichen planus and application of the pharmaceutical composition. The composition is prepared from traditional Chinese medicinal raw materials and excipients. The traditional Chinese medicinal raw materials comprise the following components in parts by weight: 25-40 parts of radix scrophulariae, 25-40 parts of monthly rose, 12-20 parts of dried rehamnnia root and 5-12 parts of willow root. The pharmaceutical composition is used for treating oral lichen planus in an external application way; after medicating for 4 weeks, the damage area of mucous membrane of the patient is obviously reduced and the pain is obviously relieved; the effective rate reaches 94.7%; the curative effect of the pharmaceutical composition is obviously better than the conventional treatment.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating oral lichen planus and an application thereof. Background technique [0002] Oral lichenplanus (OLP) is an inflammatory skin and mucosal disease mediated by T cells of unknown etiology, and is one of the common diseases of oral mucosa. Modern medicine also has no clear etiology of oral lichen planus. It is believed that it may be related to mental factors, infections, drugs, chronic lesions, systemic diseases, enzyme abnormalities, endocrine abnormalities, or qi stagnation and blood stasis. This disease is prone to occur in middle-aged people, and women are more than men. Current local treatments include gargling with antibiotic solution, intralesional injection or topical corticosteroids, and 0.1% tretinoin ointment. However, long-term external use of glucocorticoids often produces adverse reactions suc...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P1/02
Inventor 江志鑫
Owner 河南御艾堂生物科技有限公司
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