Cream for promoting healing of oral mucosa skin

Abstract

The invention relates to the technical field of oral cavity and skin health care, and particularly discloses a cream for promoting oral mucosa skin healing, the cream comprises the following raw materials by weight: 5-10% of a functional component, 5-10% of a repairing component, 5-8% of an emulsifier, 3-5% of a stabilizer, 20-30% of a matrix, and the balance deionized water; the functional component comprises a kiwi fruit extracting solution; the repairing component comprises hyaluronic acid; the emulsifier is mixed stearate; the technical problems that an existing cream is single in function, and complex requirements of multiple stages and multiple targets in the oral mucosa and skin healing process are difficult to meet at the same time are solved; the obtained cream can be simultaneously suitable for healing of skin and oral mucosa, and is suitable for healing of skin wounds such as burns, scalds, scratches and the like; treating dermatitis, eczema and other skin inflammations; the traditional Chinese medicine composition can be used for treating oral mucosa such as oral ulcer, oral mucositis, thrush, erosive oral lichen planus and the like, and has a wide application prospect.

Description

Technical Field

[0001] This application relates to the technical field of oral and skin care, and more specifically, it relates to a cream for promoting the healing of oral mucosa and skin. Background Art

[0002] The oral mucosa and skin together constitute an important defense line for the human body to resist external harmful substances (such as bacteria, viruses, chemical substances, etc.). As the first barrier for the human body to contact the external environment, the oral mucosa and skin are easily damaged by physical, chemical, biological and other factors. Damage to the oral mucosa easily leads to problems such as oral ulcers, oral mucositis, oral mucosal lesions, etc., while skin damage may cause consequences such as infection and scar formation. Therefore, it is of great significance to develop a product that can effectively promote the healing of oral mucosa and skin.

[0003] A cream is a semi-solid topical preparation, which has the characteristics of being delicate, soft and easy to apply, and can evenly adhere to the surface of the skin or mucosa to play a local therapeutic or protective role. Creams are widely used in the fields of medicine, cosmetics and skin care products for treating skin diseases, promoting wound healing, moisturizing, anti-inflammatory, etc. There are a wide variety of creams on the existing market, but most of them focus on single functions (such as anti-inflammatory or antibacterial), and it is difficult to simultaneously meet the complex needs of multiple stages and multiple targets in the healing processes of oral mucosa and skin. Existing skin creams are difficult to be simultaneously applicable to both oral mucosa and skin tissues due to strong irritation or unsuitable dosage forms, which limits their clinical application scope. Existing oral mucosa creams can only provide temporary relief for the symptoms of oral mucosal diseases, and cannot provide radical treatment effects for specific types of oral mucosal diseases (such as oral ulcers, gingivitis, stomatitis, oral mucosal lesions, etc.), and the efficacy persistence is insufficient; some creams contain specific drug components (such as chlorhexidine), and long-term use is likely to disrupt the balance of the oral microbiota, resulting in side effects such as oral mucosal discomfort, tooth discoloration, and taste change. With the increasing attention of people to oral health and skin health, the market demand for creams that can simultaneously promote the healing of oral mucosa and skin is constantly increasing. Based on the above statements, this application provides a cream for promoting the healing of oral mucosa and skin. Summary of the Invention

[0004] In order to solve the problems that existing creams mostly focus on single functions and are difficult to simultaneously meet the complex needs of multiple stages and multiple targets in the healing processes of oral mucosa and skin, etc., this application provides a cream for promoting the healing of oral mucosa and skin.

[0005] This application provides a cream for promoting the healing of oral mucosa and skin, adopting the following technical solutions: A cream for promoting the healing of oral mucosa and skin, comprising raw materials in the following weight percentages: 5-10% of active ingredients, 5-10% of repair ingredients, 5-8% of emulsifier, 3-5% of stabilizer, 20-30% of matrix, and the balance being deionized water; The active ingredients include kiwifruit extract; the repair ingredients include hyaluronic acid; the emulsifier is a mixed stearate.

[0006] Preferably, the active ingredients further include rabdosia rubescens extract, and the mass ratio of the kiwifruit extract to the rabdosia rubescens extract is 3-5:1-2.

[0007] Preferably, the kiwifruit extract is prepared by the following method: After washing, peeling and cutting the kiwifruit, place it in a juicer, add water according to the mass ratio of 1:1.5-2, beat into pulp, centrifuge to obtain the supernatant, and concentrate the supernatant to 30-40% of the original volume with a rotary evaporator to obtain the kiwifruit extract.

[0008] Preferably, the rabdosia rubescens extract is prepared by the following method: Dry and crush the rabdosia rubescens to obtain 80-100 mesh rabdosia rubescens fine powder; According to the mass ratio of material to liquid of 1:7-11, mix the rabdosia rubescens fine powder with an ethanol aqueous solution, place it in an ultrasonic extractor, filter after ultrasonic extraction, and concentrate the extract to 50-60% of the original volume with a rotary evaporator to obtain the rabdosia rubescens extract.

[0009] Preferably, the repair ingredients further include chlorella polysaccharide and aloe extract, and the mass ratio of the hyaluronic acid, chlorella polysaccharide and aloe extract is 2-5:1-3:1-3.

[0010] Preferably, the mixed stearate includes polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10-15:2-4:1.

[0011] Preferably, the stabilizer includes lecithin and elemi oil in a mass ratio of 4-7:1-3.

[0012] Preferably, the matrix is selected from at least one of liquid paraffin, beeswax, stearic acid, sodium stearate, hydrogenated castor oil, sesame oil, glycerol, polyethylene glycol.

[0013] Preferably, the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6-9:3-5:2-3:1.

[0014] A preparation method of a cream for promoting the healing of oral mucosa and skin, comprising the following preparation steps: S1. Weigh the raw material active ingredients, repair ingredients, emulsifiers, stabilizers, matrix and deionized water for standby according to the weight percentage; S2. Mix the active ingredients and stabilizers and perform ultrasonic treatment until fully dispersed to form a liposome structure. Mix and heat the matrix and emulsifiers until completely melted, then stir and mix evenly to obtain the oil phase. Add the repair ingredients to the deionized water, heat to 70 - 75 °C, and stir until completely dissolved to obtain the water phase; S3. Add the liposome structure to the oil phase, stir evenly, then add the water phase and continue to stir evenly. After homogenization treatment, the cream for promoting the healing of oral mucosa and skin is obtained.

[0015] In summary, the present application has the following beneficial effects: The present application uses active ingredients, repair ingredients, emulsifiers, stabilizers, matrix and deionized water to jointly prepare a cream for promoting the healing of oral mucosa and skin, solving the technical problems such as the single function of existing creams and the difficulty in simultaneously meeting the complex requirements of multiple stages and multiple targets during the healing processes of oral mucosa and skin; achieving antibacterial, anti-inflammatory, antioxidant, astringent and wound-healing effects by selecting active ingredients; selecting repair ingredients to promote wound healing; using stabilizers to improve the stability and permeation and absorption of active ingredients on the one hand, and improving the stability, adhesiveness and anti-saliva dilution of the cream on the other hand; the selection of the emulsifier mixed stearate can help the oil phase and water phase to mix, form a stable cream system, increase the viscosity of the cream, and improve its stability and adhesiveness; the preparation method of the cream in the present application is simple and the preparation conditions are mild. The obtained cream can be simultaneously applicable to the healing of skin and oral mucosa, and the indications include the healing of skin traumas such as burns, scalds and scratches; the treatment of skin inflammations such as dermatitis and eczema; the treatment of oral mucosa such as oral ulcers, oral mucositis, thrush and erosive oral lichen planus, having a wide application prospect.

[0016] The kiwifruit extract of the present application is rich in vitamin C, natural organic acids and polyphenolic substances, having significant antibacterial, anti-inflammatory, soothing and antioxidant effects, helping to relieve the swelling and pain of mucosa and skin, reducing infections, and promoting the healing and repair of oral mucosa and skin; the Rabdosia rubescens extract has a broad-spectrum antibacterial effect, can inhibit the growth of pathogenic microorganisms, reduce the inflammatory reaction, help to reduce exudate, and can improve local blood circulation while inhibiting the release of inflammatory mediators, providing nutrition for the wound; using the kiwifruit extract and the Rabdosia rubescens extract together as active ingredients can, on the one hand, significantly expand the antibacterial spectrum, enhance the prevention and control ability of wound infections, reduce the inflammatory reaction around the wound, and shorten the healing time; on the other hand, the combination of the two can also accelerate cell proliferation and tissue regeneration, inhibit excessive fibrosis, reduce scar formation, and promote the smooth repair of skin and mucosa.

[0017] This application uses hyaluronic acid, chlorella polysaccharide, and aloe extract as repair components together. Hyaluronic acid can promote cell proliferation and tissue regeneration, and accelerate wound healing; chlorella polysaccharide has the effect of promoting collagen synthesis and accelerating tissue repair; aloe extract can promote cell proliferation and differentiation, and accelerate wound healing; the combined use of the three can significantly accelerate the tissue repair of the skin and mucous membranes and shorten the healing time; the repair components of the present invention can significantly enhance the repair effect of the cream through multiple action mechanisms such as moisturizing, promoting repair, anti-inflammatory, antioxidant, and antibacterial; the synergistic effect of the three can not only accelerate wound healing, but also reduce scar formation, and is applicable to various skin and oral mucosa indications.

[0018] This application selects the compound of lecithin and elemi oil as a stabilizer. Lecithin can form a film to enhance the adhesion of the cream on the oral mucosa, and the terpene components in elemi oil can increase the viscosity of the cream, making it adhere more firmly to the mucosal surface. The combined use of the two can improve the film-forming property, hydrophobicity, and anti-dilution property of the cream, and prolong the onset time of the cream in the oral cavity; by pre-using the stabilizer to wrap the active ingredients to form a stable liposome structure, the stability, permeability, and absorption of the active ingredients can be significantly improved, and their bioavailability can be enhanced, thus enhancing the therapeutic effect.

[0019] This application selects liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil as the matrix together, which has good permeability, moisturizing property, and astringency. It can not only provide the nutrients required by the skin and oral mucosa, accelerate the wound healing and repair, but also protect the wound and prevent wound infection; the selection of the compound matrix in this application can effectively adjust the viscosity of the cream, making the cream easy to apply and absorb, and can form a protective film on the skin surface, providing a good release environment for the drug while preventing external irritation and water loss, and protecting the wound from contamination. Description of the Drawings

[0020] Figure 1 It is the general morphological diagram of the back wounds of rats in Example 1 of this application and Control Groups 1-2 from occurrence to healing.

[0021] Figure 2 It is the change diagram of the wound healing rate of the back wounds of rats in Example 1 of this application and Control Groups 1-2. Detailed Description of the Invention

[0022] The following further elaborates on this application in combination with Preparation Examples and Examples.

[0023] The raw materials used in the Examples and Control Groups of this application are as follows: Hyaluronic acid, particle size 80 mesh, content 99%, purchased from Qingdao Yuekang Biotechnology Co., Ltd.; Chlorella polysaccharide, specification 10:1, mesh number 120 mesh, purchased from Ningxia Vanilla Biotechnology Co., Ltd.; Aloe vera extract, CAS No. 85507-69-3, specification 10:1, purchased from Jiangsu Weizhirun Biotechnology Co., Ltd.; Polyethylene glycol-7 stearate, content 99%, purchased from Hubei Xingyan New Materials Technology Co., Ltd.; Polyglycerol monostearate, CAS No. 27321-72-8, purchased from Jiangsu Jiujia Biotechnology Co., Ltd.; Sorbitan tristearate, CAS 26658-19-5, purchased from Jiangsu Jiujia Biotechnology Co., Ltd.; Soybean lecithin, mesh number 120, purchased from Hubei Haijia Biotechnology Co., Ltd.; Elemi oil, CAS No. 9000-75-3, purchased from Hubei Xinyuhong Biomedical Technology Co., Ltd.; Liquid paraffin, CAS No. 8012-95-1, model CP2020, purchased from Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.; White beeswax, purchased from Xi'an Green Biotechnology Co., Ltd.; Sesame oil, purchased from Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.; Hydrogenated castor oil, CAS No. 8001-78-3, purchased from Xi'an Hongyao Pharmaceutical Excipients Co., Ltd.

[0024] Kiwi fruit extract is prepared by the following method: Wash, peel and cut fresh Nanyang kiwi fruits, then place them in a juicer. Add water according to the mass ratio of 1:1.5, make a pulp, centrifuge to obtain the supernatant, control the centrifugation speed at 5000 rpm and the centrifugation time at 8 min, and concentrate the supernatant to 40% of the original volume with a rotary evaporator to obtain kiwi fruit extract.

[0025] Rabdosia rubescens extract is prepared by the following method: Place Rabdosia rubescens in a hot air oven at 60 °C for 4 h and then pulverize to obtain 100-mesh Rabdosia rubescens fine powder; According to the mass ratio of material to liquid of 1:9, mix Rabdosia rubescens fine powder with 70% ethanol aqueous solution, place it in an ultrasonic extractor, set the ultrasonic power at 400 W, the ultrasonic frequency at 32 KHz, the ultrasonic temperature at 45 °C, and the ultrasonic time at 30 min. After ultrasonic extraction, filter through a 10-μm filter membrane to obtain the extract, and concentrate the extract to 50% of the original volume with a rotary evaporator to obtain Rabdosia rubescens extract.

[0026] Examples 1-3 provide a cream for promoting oral mucosa and skin healing. Example 1

[0027] A cream for promoting the healing of oral mucosa and skin, comprising raw materials in the following weight percentages: 5% of active ingredients, 5% of repair ingredients, 5% of emulsifier, 3% of stabilizer, 20% of matrix, and the balance being deionized water; Among them, the active ingredients include kiwifruit extract and rabdosia rubescens extract in a mass ratio of 3:1; the repair ingredients include hyaluronic acid, chlorella polysaccharide, and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate, and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soybean lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0028] A cream for promoting the healing of oral mucosa and skin is prepared by the following method: S1. Weigh the raw materials of active ingredients, repair ingredients, emulsifier, stabilizer, matrix, and deionized water for standby according to the weight percentages; S2. After mixing the active ingredients and the stabilizer, place them under ultrasonic treatment with an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75 °C for 20 min until fully dispersed to form a liposome structure. Heat and stir the matrix and the emulsifier until completely melted and then mix them evenly to obtain an oil phase. Add the repair ingredients to deionized water, heat to 70 °C, and stir until completely dissolved to obtain an aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until uniform, then add the aqueous phase and continue to stir for 20 min until uniform. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting the healing of oral mucosa and skin. Example 2

[0029] A cream for promoting the healing of oral mucosa and skin, comprising raw materials in the following weight percentages: 8% of active ingredients, 6% of repair ingredients, 6.5% of emulsifier, 4% of stabilizer, 25% of matrix, and the balance being deionized water; Among them, the active ingredients include kiwifruit extract and rabdosia rubescens extract in a mass ratio of 4:1.5; the repair ingredients include hyaluronic acid, chlorella polysaccharide, and aloe extract in a mass ratio of 3.5:2:2; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate, and sorbitan tristearate in a mass ratio of 12.5:3:1; the stabilizer includes soybean lecithin and elemi oil in a mass ratio of 5.5:2; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil in a mass ratio of 7.5:4:2.5:1.

[0030] A cream for promoting the healing of oral mucosa and skin is prepared by the following method: S1. Weigh the raw material efficacy components, repair components, emulsifiers, stabilizers, matrix, and deionized water according to the weight percentage for standby. S2. After mixing the efficacy components and stabilizers, place them under ultrasonic treatment at an ultrasonic power of 350 W, an ultrasonic frequency of 35 KHz, and an ultrasonic temperature of 70 °C for 25 minutes until fully dispersed to form a liposome structure. Heat and stir the matrix and emulsifiers until completely melted and then mix them evenly to obtain the oil phase. Add the repair components to the deionized water, heat to 70 °C, and stir until completely dissolved to obtain the water phase. S3. Add the liposome structure to the oil phase, control the stirring speed at 500 rpm, stir for 15 minutes until uniform, then add the water phase and continue stirring for 15 minutes until uniform. Control the homogenization speed at 9000 rpm and perform homogenization treatment for 4 minutes to obtain the required cream for promoting oral mucosal and skin healing. Example 3

[0031] A cream for promoting oral mucosal and skin healing, comprising the following raw materials in weight percentage: 10% efficacy components, 10% repair components, 8% emulsifiers, 5% stabilizers, 30% matrix, and the balance is deionized water. Among them, the efficacy components include kiwifruit extract and rabdosia rubescens extract in a mass ratio of 5:2; the repair components include hyaluronic acid, chlorella polysaccharide, and aloe extract in a mass ratio of 5:3:3; the emulsifier is a mixed stearate, specifically including polyethylene glycol - 7 stearate, triglycerol monostearate, and sorbitan tristearate in a mass ratio of 15:4:1; the stabilizer includes soybean lecithin and elemi oil in a mass ratio of 7:3; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil in a mass ratio of 9:5:3:1.

[0032] A cream for promoting oral mucosal and skin healing is prepared by the following method: S1. Weigh the raw material efficacy components, repair components, emulsifiers, stabilizers, matrix, and deionized water according to the weight percentage for standby. S2. After mixing the efficacy components and stabilizers, place them under ultrasonic treatment at an ultrasonic power of 400 W, an ultrasonic frequency of 30 KHz, and an ultrasonic temperature of 65 °C for 30 minutes until fully dispersed to form a liposome structure. Heat and stir the matrix and emulsifiers until completely melted and then mix them evenly to obtain the oil phase. Add the repair components to the deionized water, heat to 75 °C, and stir until completely dissolved to obtain the water phase. S3. Add the liposome structure to the oil phase, control the stirring speed at 600 rpm, stir for 10 minutes until uniform, then add the water phase and continue stirring for 10 minutes until uniform. Control the homogenization speed at 10000 rpm and perform homogenization treatment for 3 minutes to obtain the required cream for promoting oral mucosal and skin healing.

[0033] To verify the comprehensive effects of the creams for promoting oral mucosa and skin healing prepared in Examples 1 - 3 of the present application, the applicant set Comparative Examples 1 - 7 as follows: Comparative Example 1

[0034] Same as Example 1, except that the active ingredient is only kiwifruit extract, specifically as follows: A cream for promoting oral mucosa and skin healing, comprising the following raw materials by weight percentage: active ingredient 5%, repair ingredient 5%, emulsifier 5%, stabilizer 3%, matrix 20%, and the balance being deionized water; Among them, the active ingredient is kiwifruit extract; the repair ingredient includes hyaluronic acid, chlorella polysaccharide, and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol - 7 stearate, triglycerol monostearate, and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0035] A cream for promoting oral mucosa and skin healing is prepared by the following method: S1. Weigh the raw materials of the active ingredient, repair ingredient, emulsifier, stabilizer, matrix, and deionized water by weight percentage for standby; S2. After mixing the active ingredient and the stabilizer, place them under ultrasonic treatment with an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75 °C for 20 min until fully dispersed to form a liposome structure. Heat and stir the matrix and the emulsifier until completely melted and then mix them evenly to obtain an oil phase. Add the repair ingredient to the deionized water, heat to 70 °C, and stir until completely dissolved to obtain an aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until uniform, then add the aqueous phase and continue to stir for 20 min until uniform. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting oral mucosa and skin healing. Comparative Example 2

[0036] Same as Example 1, except that the active ingredient is only rabdosia extract, specifically as follows: A cream for promoting oral mucosa and skin healing, comprising the following raw materials by weight percentage: active ingredient 5%, repair ingredient 5%, emulsifier 5%, stabilizer 3%, matrix 20%, and the balance being deionized water; Among them, the active ingredient is the extract of Rabdosia rubescens; the repair ingredients include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0037] A cream for promoting the healing of oral mucosa and skin is prepared by the following method: S1. Weigh the raw material active ingredient, repair ingredient, emulsifier, stabilizer, matrix and deionized water for standby according to the weight percentage; S2. After mixing the active ingredient and the stabilizer, place them under ultrasonic treatment with an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz and an ultrasonic temperature of 75 °C for 20 min until fully dispersed to form a liposome structure. Heat and stir the matrix and the emulsifier until completely melted and then mix them evenly to obtain an oil phase. Add the repair ingredient to the deionized water, heat it to 70 °C and stir until completely dissolved to obtain an aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until uniform, then add the aqueous phase and continue to stir for 20 min until uniform. Control the homogenization speed at 8000 rpm and carry out homogenization treatment for 5 min to obtain the required cream for promoting the healing of oral mucosa and skin. Comparative Example 3

[0038] Same as Example 1, the difference is only that the repair ingredient only selects hyaluronic acid, specifically as follows: A cream for promoting the healing of oral mucosa and skin, comprising the following raw materials in weight percentage: 5% of active ingredient, 5% of repair ingredient, 5% of emulsifier, 3% of stabilizer, 20% of matrix, and the balance is deionized water; Among them, the active ingredient includes kiwifruit extract and Rabdosia rubescens extract in a mass ratio of 3:1; the repair ingredient is hyaluronic acid; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0039] A cream for promoting the healing of oral mucosa and skin is prepared by the following method: S1. Weigh the raw material active ingredient, repair ingredient, emulsifier, stabilizer, matrix and deionized water for standby according to the weight percentage; S2. After mixing the active ingredients and the stabilizer, place them under ultrasonic treatment at an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75°C for 20 min until fully dispersed to form a liposome structure. Mix the matrix and the emulsifier, heat them until completely melted, and then stir and mix evenly to obtain the oil phase. Add the repair ingredients to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until uniform, then add the aqueous phase and continue stirring for 20 min until uniform. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting oral mucosa and skin healing. Comparative Example 4

[0040] Same as Example 1, the difference is only that the repair ingredients are hyaluronic acid and chlorella polysaccharide with a mass ratio of 3:1, specifically as follows: A cream for promoting oral mucosa and skin healing, comprising the following raw materials in weight percentages: 5% of active ingredients, 5% of repair ingredients, 5% of emulsifier, 3% of stabilizer, 20% of matrix, and the balance is deionized water; Among them, the active ingredients include kiwifruit extract and rabdosia rubescens extract with a mass ratio of 3:1; the repair ingredients include hyaluronic acid and chlorella polysaccharide with a mass ratio of 3:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate, and sorbitan tristearate with a mass ratio of 10:2:1; the stabilizer includes soybean lecithin and elemi oil with a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil with a mass ratio of 6:3:2:1.

[0041] A cream for promoting oral mucosa and skin healing is prepared by the following method: S1. Weigh the raw materials of active ingredients, repair ingredients, emulsifier, stabilizer, matrix, and deionized water according to weight percentages for standby; S2. After mixing the active ingredients and the stabilizer, place them under ultrasonic treatment at an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75°C for 20 min until fully dispersed to form a liposome structure. Mix the matrix and the emulsifier, heat them until completely melted, and then stir and mix evenly to obtain the oil phase. Add the repair ingredients to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until uniform, then add the aqueous phase and continue stirring for 20 min until uniform. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting oral mucosa and skin healing. Comparative Example 5

[0042] Same as Example 1, with the only difference being that the repair components are hyaluronic acid and aloe extract with a mass ratio of 3:1, specifically as follows: A cream for promoting the healing of oral mucosa and skin, comprising the following raw materials in weight percentages: 5% of efficacy components, 5% of repair components, 5% of emulsifier, 3% of stabilizer, 20% of matrix, and the balance being deionized water; Among them, the efficacy components include kiwifruit extract and rabdosia rubescens extract with a mass ratio of 3:1; the repair components include hyaluronic acid and aloe extract with a mass ratio of 3:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate, and sorbitan tristearate with a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil with a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil with a mass ratio of 6:3:2:1.

[0043] A cream for promoting the healing of oral mucosa and skin is prepared by the following method: S1. Weigh the raw materials of efficacy components, repair components, emulsifier, stabilizer, matrix, and deionized water according to the weight percentages for standby; S2. After mixing the efficacy components and the stabilizer, place them under ultrasonic treatment at an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75 °C for 20 min until fully dispersed to form a liposome structure. Heat and stir the matrix and the emulsifier until completely melted and then mix them evenly to obtain an oil phase. Add the repair components to deionized water, heat to 70 °C, and stir until completely dissolved to obtain an aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until homogeneous, then add the aqueous phase and continue to stir for 20 min until homogeneous. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting the healing of oral mucosa and skin. Comparative Example 6

[0044] Same as Example 1, with the only difference being that the stabilizer only selects soy lecithin, specifically as follows: A cream for promoting the healing of oral mucosa and skin, comprising the following raw materials in weight percentages: 5% of efficacy components, 5% of repair components, 5% of emulsifier, 3% of stabilizer, 20% of matrix, and the balance being deionized water; Among them, the efficacy components include kiwifruit extract and rabdosia rubescens extract with a mass ratio of 3:1; the repair components include hyaluronic acid, chlorella polysaccharide, and aloe extract with a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate, and sorbitan tristearate with a mass ratio of 10:2:1; the stabilizer is soy lecithin; the matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil with a mass ratio of 6:3:2:1.

[0045] A cream for promoting oral mucosa and skin healing is prepared by the following method: S1. Weigh the raw material efficacy components, repair components, emulsifier, stabilizer, matrix and deionized water for standby according to the weight percentage; S2. After mixing the efficacy components and the stabilizer, place them under ultrasonic treatment with an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75 °C for 20 min until fully dispersed to form a liposome structure. Heat and melt the matrix and the emulsifier completely and then stir and mix them evenly to obtain an oil phase. Add the repair components to the deionized water, heat to 70 °C, and stir until completely dissolved to obtain an aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until uniform, then add the aqueous phase and continue to stir for 20 min until uniform. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting oral mucosa and skin healing. Comparative Example 7

[0046] Same as Example 1, the difference is only that the stabilizer is only selected as elemi oil, specifically as follows: A cream for promoting oral mucosa and skin healing, comprising the following raw materials in weight percentage: 5% of efficacy components, 5% of repair components, 5% of emulsifier, 3% of stabilizer, 20% of matrix, and the balance is deionized water; Among them, the efficacy components include kiwifruit extract and isodon rubescens extract in a mass ratio of 3:1; the repair components include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer is elemi oil; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0047] A cream for promoting oral mucosa and skin healing is prepared by the following method: S1. Weigh the raw material efficacy components, repair components, emulsifier, stabilizer, matrix and deionized water for standby according to the weight percentage; S2. After mixing the efficacy components and the stabilizer, place them under ultrasonic treatment with an ultrasonic power of 300 W, an ultrasonic frequency of 40 KHz, and an ultrasonic temperature of 75 °C for 20 min until fully dispersed to form a liposome structure. Heat and melt the matrix and the emulsifier completely and then stir and mix them evenly to obtain an oil phase. Add the repair components to the deionized water, heat to 70 °C, and stir until completely dissolved to obtain an aqueous phase; S3. Add the liposome structure to the oil phase, control the stirring speed at 400 rpm, stir for 20 min until homogeneous, then add the aqueous phase and continue to stir for 20 min until homogeneous. Control the homogenization speed at 8000 rpm and perform homogenization treatment for 5 min to obtain the required cream for promoting oral mucosal and skin healing. Performance Test

[0048] Test the therapeutic effects of the creams for promoting oral mucosal and skin healing prepared in Examples 1-3 and Comparative Examples 1-7 of the present application on oral ulcers respectively. I. Rat Oral Ulcer Healing Experiment

[0049] Experimental content: There are 36 clean-grade SD rats (body weight 280 - 320 g). Randomly divide the 36 SD rats into 12 groups, with 3 rats in each group, and name them as groups of Examples 1-3 and Comparative Examples 1-7, model group, and blank control group respectively.

[0050] Before modeling, feed and drink freely and adaptively raise for one week. Chemically burn and model the buccal mucosa of the rats in groups of Examples 1-3 and Comparative Examples 1-7 and the model group with glacial acetic acid. Specifically, inject the rats intraperitoneally with sodium pentobarbital (concentration 1%, 0.5 ml / 100 g) for anesthesia. Then, use a cotton thread to open the rat's mouth, use a 200-μl pipette tip to make a mold of a fixed size, put a small amount of cotton balls into the mold, suck 15 μl of 80% glacial acetic acid, after the cotton balls absorb it, place it on the lip side mucosa of the anesthetized rat for 30 s (chemically burn the epithelial mucosa layer), then remove the residual glacial acetic acid, and record the immediate reaction at the treatment site. Number the tails and raise them normally for 24 h, and observe the formation of oral ulcers in the rats. The blank control is not modeled. Compare with the blank control, the oral ulcer wounds in each group are obvious, and the ulcer surface is covered with a yellowish-white false membrane, indicating that the model is successfully established.

[0051] Treat the modeled rats 24 h after modeling is completed. The rats in groups of Examples 1-3 and Comparative Examples 1-7 are treated with the creams for promoting oral mucosal and skin healing prepared in Examples 1-3 and Comparative Examples 1-7 of the present application (0.05 g) respectively. The model group is applied with physiological saline. Treat twice a day, with an 8-h interval between treatments. Regularly observe and record the general morphology of the ulcers from occurrence to healing every day, and continue the treatment until the ulcers are completely healed as the end point. The statistical number of days for oral ulcer healing is shown in Table 1 below.

[0052] Table 1:

[0053] It can be seen from the data shown in Table 1 above that: The healing conditions of the ulcer surfaces of the creams for promoting oral mucosal and skin healing prepared in Examples 1-3 of the present embodiment are significantly better than those of Comparative Examples 1-7 and the model group. The effect of promoting oral mucosa is remarkable and worthy of promotion.

[0054] II. Experiment on the healing of back wounds in rats Experimental content: A total of 30 specific-pathogen-free (SPF) SD rats (weighing 280 - 320 g) were randomly divided into 10 groups, with 3 rats in each group, named as Example 1 - 3 and Comparative Example 1 - 7 groups respectively. The back hair of the rats was shaved off, and after cleaning it with depilatory cream, a circular cut surface was made to create a skin defect model on the back of the mice.

[0055] 24 hours after the model was established, the modeled rats were treated. The rats in Example 1 - 3 and Comparative Example 1 - 7 groups were treated with the creams (0.1 g) for promoting oral mucosa and skin healing prepared in Example 1 - 3 and Comparative Example 1 - 7 of the present application respectively. The residual area of the wound was observed and recorded regularly every day, and the continuous treatment was ended until the wound healed completely. The number of days for wound healing was counted as shown in Table 2 below.

[0056] Table 2:

[0057] From the data shown in the above Table 2 and Figure 1-2 It can be seen that: The healing of the back wounds of the creams for promoting oral mucosa and skin healing prepared in Example 1 - 3 of the present application is significantly better than that of Comparative Example 1 - 7, and the effect of promoting skin healing is remarkable, which is worthy of promotion.

[0058] This specific embodiment is only an interpretation of the present application, and it is not a limitation to the present application. Those skilled in the art can make modifications without creative contributions to this embodiment after reading this specification, but as long as it is within the scope of the claims of the present application, it is protected by the patent law.

Claims

1. A cream for promoting oral mucosa and skin healing, characterized in that, It comprises raw materials in the following weight percentages: 5 - 10% of active ingredients, 5 - 10% of repair ingredients, 5 - 8% of emulsifiers, 3 - 5% of stabilizers, 20 - 30% of matrix, and the balance is deionized water; The active ingredients include kiwifruit extract; the repair ingredients include hyaluronic acid; the emulsifier is a mixed stearate.

2. The cream for promoting oral mucosa and skin healing according to claim 1, characterized in that, The active ingredients further include rabdosia rubescens extract, and the mass ratio of the kiwifruit extract to the rabdosia rubescens extract is 3 - 5:1 - 2.

3. The cream for promoting oral mucosa and skin healing according to claim 2, characterized in that, The kiwifruit extract is prepared by the following method: After washing, peeling, and cutting the kiwifruit, place it in a juicer, add water according to the mass ratio of 1:1.5 - 2, make a pulp, centrifuge to obtain the supernatant, and concentrate the supernatant to 30 - 40% of the original volume with a rotary evaporator to obtain the kiwifruit extract.

4. The cream for promoting oral mucosa and skin healing according to claim 2, characterized in that, The rabdosia rubescens extract is prepared by the following method: Dry and crush the rabdosia rubescens to obtain rabdosia rubescens fine powder of 80 - 100 mesh; According to the mass ratio of solid to liquid of 1:7 - 11, mix the rabdosia rubescens fine powder with an ethanol aqueous solution, place it in an ultrasonic extractor, filter after ultrasonic extraction, and concentrate the extract to 50 - 60% of the original volume with a rotary evaporator to obtain the rabdosia rubescens extract.

5. The cream for promoting oral mucosa and skin healing according to claim 1, characterized in that, The repair ingredients further include chlorella polysaccharide and aloe extract, and the mass ratio of the hyaluronic acid, chlorella polysaccharide, and aloe extract is 2 - 5:1 - 3:1 - 3.

6. The cream for promoting oral mucosa and skin healing according to claim 1, wherein The mixed stearate includes polyethylene glycol - 7 stearate, triglycerol monostearate, and sorbitan tristearate in a mass ratio of 10 - 15:2 - 4:

1.

7. The cream for promoting oral mucosa and skin healing according to claim 1, wherein The stabilizer includes lecithin and elemi oil in a mass ratio of 4 - 7:1 - 3.

8. The cream for promoting oral mucosa and skin healing according to claim 1, wherein The matrix is selected from at least one of liquid paraffin, beeswax, stearic acid, hydrogenated castor oil, sesame oil, glycerol, and polyethylene glycol.

9. The cream for promoting oral mucosa and skin healing according to claim 8, characterized in that, The matrix includes liquid paraffin, white beeswax, sesame oil, and hydrogenated castor oil in a mass ratio of 6 - 9:3 - 5:2 - 3:

1.

10. A method for preparing the cream for promoting oral mucosa and skin healing according to any one of claims 1-9, characterized in that, It includes the following preparation steps: S1. Weigh the raw materials of active ingredients, repair ingredients, emulsifiers, stabilizers, matrix, and deionized water for standby according to the weight percentages; S2. Mix the active ingredients and the stabilizer, and perform ultrasonic treatment until fully dispersed to form a liposome structure. Mix the matrix and the emulsifier, heat until completely melted, and stir and mix evenly to obtain an oil phase. Add the repair ingredients to the deionized water, heat to 70 - 75°C, and stir until completely dissolved to obtain a water phase; S3. Add the liposome structure to the oil phase, stir evenly, then add the water phase and continue to stir evenly, and perform homogenization treatment to obtain the required cream for promoting oral mucosal and skin healing.

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