A self-oxidizing cross-linked sprayable hydrogel and its preparation method and application

CN122097247APending Publication Date: 2026-05-29STOMATOLOGICAL HOSPITAL OF SHANXI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
STOMATOLOGICAL HOSPITAL OF SHANXI MEDICAL UNIVERSITY
Filing Date
2026-03-26
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing oral ulcer treatment materials have poor adhesion in moist environments, rely on external stimuli for cross-linking, and have limited functionality, making it difficult to achieve synergistic intervention in complex pathological processes.

Method used

A self-oxidative crosslinking sprayable hydrogel composed of PGA-DA@Sal-CDs was developed. It is cured in air through a self-oxidative crosslinking process and combines the dopamine structure of PGA with the antioxidant, anti-inflammatory and antibacterial functions of Sal-CDs to achieve a multifunctional synergistic effect.

Benefits of technology

This hydrogel achieves in-situ curing without external stimulation, possesses excellent adhesion and sprayability, can eliminate reactive oxygen species, regulate inflammatory responses and inhibit bacterial growth, promote tissue repair, and significantly improve treatment efficacy.

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Abstract

The present application belongs to the field of solving the problems of poor adhesion in a humid environment, dependence on external stimulation crosslinking and single function of existing oral ulcer treatment materials, and provides a self-oxidation crosslinking sprayable hydrogel as well as a preparation method and application thereof, wherein the hydrogel is PGA-DA@Sal-CDs hydrogel, referred to as PDS Gel, which is composed of polygalacturonic acid (PGA), dopamine (DA) and salidroside-derived carbon dots (Sal-CDs). The hydrogel can realize in-situ gelation without external stimulation, has sprayability and adhesion in a humid environment, and realizes multifunctional integration and synergistic regulation through step-by-step crosslinking strategy and stable network structure, thereby significantly promoting the wound repair process. The hydrogel is applied to the remodeling of the microenvironment of recurrent oral ulcer and acceleration of healing, and the hydrogel is sprayable, self-crosslinking and solidifying, and has anti-inflammatory, antioxidant and antibacterial multifunctional synergistic effects, so as to realize comprehensive regulation of the ulcer microenvironment and promote wound repair.
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