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Combination of medication for reducing poison and synergic action in radiotherapy or chemotherapy as well as its preparing method

A composition and drug technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of target dispersion, unclear active ingredients, and influence on curative effect, so as to block overgrowth and enhance killing Function, cellular immunity and humoral immune function enhancement effect

Inactive Publication Date: 2004-03-10
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of this kind of Chinese patent medicines have simple preparation process, unclear active ingredients, and some have scattered targets, which affect the curative effect, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0237] Take astragalus 3.0kg, medlar 1.2kg, ganoderma lucidum 1.2kg.

[0238] For the first time, use 8 times the amount of Astragalus membranaceus, and for the second time, use 6 times the amount of 80% ethanol to reflux extract twice, each time for 2 hours, combine the reflux liquid, filter, recover ethanol, leave the mother liquor for 12 hours, centrifuge, and put the centrifugal liquid on the Treated AB-8 macroporous resin for purification, eluted with 70% ethanol, recovered ethanol, dried to obtain 30 g of total saponins.

[0239] Astragalus dregs, Lycium barbarum, Ganoderma lucidum and other prescription medicines are extracted three times with 12 times the amount of water, each time for 1.5 hours, combined with the decoction liquid, concentrated to a relative density of 1.2 (80°C), ethanol precipitation with an alcohol content of 80%, standing still, and filtering , the precipitate was evaporated to dryness with ethanol, added distilled water to dissolve, centrifuged, t...

Embodiment 2

[0242] Take astragalus 3.0kg, medlar 1.2kg, ganoderma lucidum 1.2kg.

[0243] For the first time, use 8 times the amount of Astragalus membranaceus, and for the second time, use 6 times the amount of 80% ethanol to reflux extract twice, each time for 2 hours, combine the reflux liquid, filter, recover ethanol, leave the mother liquor for 12 hours, centrifuge, and put the centrifugal liquid on the Treated AB-8 macroporous resin for purification, eluted with 70% ethanol, recovered ethanol, dried to obtain 30 g of total saponins.

[0244] Astragalus dregs, Lycium barbarum, Ganoderma lucidum and other prescription medicines are extracted three times with 12 times the amount of water, each time for 1.5 hours, combined with the decoction liquid, concentrated to a relative density of 1.2 (80°C), ethanol precipitation with an alcohol content of 80%, standing still, and filtering , the precipitate was evaporated to dryness with ethanol, added distilled water to dissolve, centrifuged, t...

Embodiment 3

[0247] Take astragalus 4.0kg, medlar 1.5kg, ganoderma lucidum 1.5kg.

[0248] The Astragalus membranaceus of described weight ratio is extracted 4 times with 90% ethanol, each time for 2.5 hours, the ethanol extracts are combined, the ethanol is reclaimed, the liquid after the precipitation is removed is put on the AB-8 macroporous resin column, washed with 80% ethanol Take off, get 40 grams of Astragalus total saponins;

[0249] Combine the Lycium barbarum and Ganoderma lucidum in the weight ratio with the above-mentioned ethanol-extracted Astragalus residue, add 10 times the amount of water, decoct 4 times, each time for 2 hours, combine the decoction liquid, concentrate to a relative density of 1.3, add ethanol to make the When the alcohol content reaches 70%, filter the precipitate, dry the precipitate, add water to dissolve it, concentrate the water to a relative density of 1.1, add ethanol to make the alcohol content reach 70%, filter the precipitate, and dry to obtain 1...

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PUM

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Abstract

A detoxicating synergistic Chinese medicine for radiotherapy or chemicotherapy is prepared from astragalus root, wolfberry fruit and ganoderma. Its advantage is high curative effect.

Description

technical field [0001] The invention relates to a medicine for reducing toxicity and enhancing efficacy of radiotherapy and chemotherapy and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Malignant tumors are common and frequently-occurring diseases in my country. At present, almost all anticancer drugs belong to the category of cytotoxicity. While killing tumor cells, anticancer drugs also seriously damage normal tissues. This unavoidable side effect limits the application and efficacy of anticancer drugs. . A few days ago, the common drugs used in the market for reducing toxicity and increasing the efficacy of radiotherapy and chemotherapy include ribonucleic acid, Chinese patent medicines such as Zhenqi Fuzheng Granules, Yunzhi Polysaccharide Capsules, and Jinghuangzhi Oral Liquid (Shaanwei Yaozhunzi (1993 No. 001612)), etc. . Some of these proprietary Chinese medicines have simple preparation proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P37/02
Inventor 段金廒贾晓斌彭蕴茹
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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