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Application of cantharis in medicament preparation

The technology of cantharidin and norcantharidin is applied in the field of cantharidin mixture and cantharidin, which can solve the problems of affecting life and work, affecting appearance and beauty, and achieve the effect of strong pharmacological action and good medicinal prospect.

Inactive Publication Date: 2006-12-20
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Except for the leukoplakia formed by partial skin depigmentation, patients usually have no other symptoms, but because it is more common in young people and affects the appearance, it often causes an invisible psychological pressure on the patient, and even affects normal life and work.
[0006] Currently on H 22 There are no effective drugs for liver cancer, systemic lupus erythematosus, and vitiligo

Method used

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  • Application of cantharis in medicament preparation
  • Application of cantharis in medicament preparation
  • Application of cantharis in medicament preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Mylabris in the preparation of treatment or prevention of H 22 Drug application in liver cancer

[0037] 1 Materials and methods

[0038] 1.1 Experimental materials

[0039] 1.1.1 Preparation of Mylabris: Take the decoction pieces of Chinese herb Mylabris, put them in a decoction container, add cold water equivalent to 5-7 times the amount of medicinal materials, soak for 1-2 hours, boil for 30 minutes, and filter. Add 3-5 times the amount of water to the dregs and continue to decoct, boil for 20 minutes, and filter. The two filtrates were combined, concentrated on a water bath to a liquid medicine equivalent to 0.01g / ml of the original medicinal material, cooled and filled into sterilized medicine bottles, and placed in a 4°C refrigerator for later use.

[0040] 1.1.2 Animals: C57BL / 6 mice, male, 10 weeks old, purchased from Animal Center of Shanghai Chinese Academy of Sciences.

[0041] 1.1.3 Tumor Strain: Liver Cancer H 22 Tumor strains were provided by Shanghai...

Embodiment 2

[0067] The cantharidin mixture containing hydroxycantharidin is used in the preparation of treatment or prevention of H 22 Drug application in liver cancer

[0068] 1 Materials and methods

[0069] 1.1 Experimental materials

[0070] 1.1.1 Mylabris mixture: the content of mylabris in the mylabris mixture is 0.02g / ml.

[0071] 1.1.2 Animals: C57BL / 6 mice, male, 10 weeks old, purchased from Animal Center of Shanghai Chinese Academy of Sciences.

[0072] 1.1.3 Tumor Strain: Liver Cancer H 22 Tumor strains were provided by Shanghai Institute of Immunology.

[0073] 1.1.4 Reagents: ConA (Sigma Company), CD3, CD4, CD8 monoclonal antibodies (eBioScience Company), NK cell killing reagents (made by Shanghai Institute of Immunology), 3 H-TdR (Shanghai Institute of Atomic Energy), IFN-γ and IL-4 detection kit (Jingmei Company).

[0074] 1.2 Experimental method

[0075] 1.2.1 Modeling method: Under sterile conditions, take the H 22 Cell line, cells 5×10 6 Inoculated subcutaneousl...

Embodiment 3

[0091] Application of cantharidin in preparation of medicine for treating or preventing systemic lupus erythematosus

[0092] 1. Animals and Materials

[0093] Experimental animals: 60 systemic lupus erythematosus experimental rats, body weight 200±10g, age 160 days, 4 rats per cage, room temperature 23±2°C, humidity 30-50%, refined pellet feed,

[0094] 2. Grouping

[0095] We randomly divided the above 60 experimental mice with systemic lupus erythematosus into two corticosteroid treatment groups of 30 cases: this group was injected with corticosteroids at a dose of 0.01 g per day for 15 consecutive days.

[0096] 30 cases in the mylabris treatment group: this group was given 0.01 g / ml of mylabris water decoction, and 0.2 ml / piece was given by intragastric administration, and the administration was continued for 15 days.

[0097] 3. Observation

[0098] Mylabris treatment group: the days needed to improve the main clinical symptoms of fever, joint swelling and pain, skin ...

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Abstract

The invention relates to the application of cantharis and cantharis mixture, wherein said application comprises: (1) the invention develops new application of cantharis and cantharis mixture; (2) the inventive cantharis and cantharis mixture have low toxicity and strong pharmacological function, and wider application; (3) the invention can restrain cancer growing and adjust the immunity of human body, to support clinical cancer treatment.

Description

technical field [0001] The present invention relates to the use of mylabris and mylabris mixture, in particular to their application in the field of pharmacy. Background technique [0002] As early as the thirteenth century, "Renzhai Zhizhifang" has recorded that mylabris can be used to treat breast cancer and abdominal cancer. The ancients also often used the folk prescription of "boil eggs with mylabris, discard the eggs with mylabris" to treat liver cancer and other digestive system cancers, and it is still used by the people today. Chinese medicine believes that mylabris is cold in nature, pungent in taste, and poisonous. According to the records of "Shen Nong's Materia Medica", mylabris can treat diseases such as carbuncle, ulcer, ringworm and sore, and has the effects of attacking poisonous erosion, breaking blood and dissipating stagnation. It has been found clinically that it has a variety of new uses, and it has a unique curative effect on treating some difficult ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P35/00A61P17/00A61P37/02
Inventor 周阿高张勇孔德云葛海良任秋华
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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